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Tissue browser help

In this tissue browser, you can find disease complexes that are either under- or overexpressed in a given tissue. The complexes are ordered by expression level, so you will find overexpressed complexes in the top of the list, and underexpressed complexes in the bottom.

Start by selecting a tissue from the dropdown menu and whether you want to include redundant complexes or not. The page will be updated with the tissue information after you press 'Go!'.

The table can be ordered by any column. The row colors represent the z-score associated with the tissue for each complex, according to the following range:
Z-Score
-2 0 2
Clicking on any row of the table will take you to the corresponding complex on the complex browser window.

Redundancy reduced

Because some complexes overlap in protein context we redundancy reduced the set of complexes, based on substantial overlaps (similar to the procedure reported in Gavin et al., 2001). Specifically, we consider two complexes to be overlapping if they included the same subset of disease-associated proteins from OMIM. Furthermore, we considered two complexes having 35% of their proteins in common overlapping. For example, if a complex of size 3 had one protein in common with another complex, both complexes would stay in the redundancy reduced data set, and if a complex with 5 proteins had 2 proteins in common with another pull-down, one of them would be removed from the redundancy reduced data set. When two protein complexes given these criteria were considered overlapping, the complex with the most significant enrichment of an OMIM disease was kept in the redundancy reduced set (see Methods and Supplementary Information for information on the calculation of OMIM disease enrichment). If both complexes were more enriched than detectable by our measurements, the smaller one was added to the redundancy reduced set. See Supplementary Information for more details.