The course starts Tuesday, June 06 and runs every day from 9.00 - 16.00 over a three weeks period, ending Monday, June 26. The course consists of lectures, exercises and project work, held at: DTU, Building 210, lecture room 168.
Litterature for the course in Immunological Bioinformatics: "Immunological Bioinformatics", Lund et al., MIT Press 2005.
 Tuesday, June 6
- Reading: Chapters 1+12
- 9.00 - 9.45
- Introduction to the course
Ole Lund, Claus Lundegaard, Morten Nielsen, CBS
- 9.45 - 10.00
- coffee break
- 10.00 - 10.45
- The immune system.
Christina Sylvester-Hvid, Wiborg Biotech Consulting, ApS.
- 10.50 - 12.00
- Cellular Immunity.
Christina Sylvester-Hvid, Wiborg Biotech Consulting, ApS..
- 12.00 - 13.00
- lunch break
- 13.00 - 15.00
- Exercises:
Databases and web resources in Immunological bioinformatics. Ole Lund + Morten Nielsen, CBS
Wednesday, June 7
- Reading: Chapters 2+10+11+13
- 9.00 - 9.30
- Challenges to the Immune System PowerPoint Slides
Ole Lund, CBS
- 9.35 - 10.00
- Conventional Vaccines
Ole Lund, CBS
- 10.00 - 10.15
- Coffee Break
- 10.15 - 10.45
- Antibodies I, Slides: PowerPoint KeyNote (Mac)
Claus Lundegaard, CBS
- 10.50 - 11.20
- Antibodies II
Claus Lundegaard, CBS
- 11.25 - 12.00
- HLA Diversity and Evolution PowerPoint Slides
Ole Lund, CBS
- 12.00 - 13.00
- lunch break
- 13.00 - 15.00
- Exercises:
Using the IMGT Web tools and databases. Claus Lundegaard and Morten Nielsen, CBS
Thursday, June 8
- Reading: Synthetic and natural non-live vectors: rationale for their clinical development in cancer vaccine protocols
- 9.00 - 9.30
- T-Cell epitope discovery.
Thomas Blicher, CBS
- 9.35 - 10.00
- Generation of recombinant MHC and peptide competition (RIA) assays.
Kasper Lamberth, IMMI, Universitu of Copenhagen
- 10.00 - 10.15
- Coffee Break
- 10.15 - 10.45
- Recombinant MHC - peptide binding assays using Elisa and Alpha Screen.
Mikkel Harndal, IMMI, University of Copenhagen
- 10.50 - 11.20
- Epitopes in diagnostics.
Jean Vennestrøm, CBS
- 11.25 - 12.00
- Structures and Homology modelling PowerPoint slides
Morten Nielsen, CBS
- 12.00 - 13.00
- Lunch Break
- 13.00 - 15.00
- Exercises:
Unix crash course. Ole Lund + Morten Nielsen, CBS
Friday, June 9
- Reading: Chapters 3+4
- 9.00 - 10.00
- Biological Sequence Analysis Keynote Slides PowerPoint Slides
Claus Lundegaard, CBS
- 10.00 - 10.15
- Coffee Break
- 10.15 - 12.00
- Maximum likelyhood phylogeny part 1 part_2
Anders Gorm Pedersen, CBS Handout calculation
- 12.00 - 13.00
- Lunch Break
- 13.00 - 17.00
- Exercises:
Viral Evolution, Anders Gorm Pedersen + Claus Lundegaard, CBS
Monday, June 12
- Reading: Chapters 5+7+9
- 9.00 - 10.00
- DNA Arrays
Hanne Jarmer, CBS
- 10.00 - 10.15
- Coffee Break
- 10.15 - 10.45
- Neural Networks.
Claus Lundegaard, CBS.
- 10.50 - 12.00
- Prediction of proteasome processing and TAP binding; The Class I Pathway PowerPoint Slides
Can Kesmir, Theoretical Biology Group, Utrecht University in the Netherlands.
- 12.10 - 13.00
- Lunch Break
- 13.00 - 16.00
- Exercises:
Proteasome and TAP predictions, Morten Nielsen + Can Kesmir, Theoretical Biology Group, Utrecht University in the Netherlands.
Tuesday, June 13
- Reading: Chapters 6 + 8
- 9.00 - 10.00
- HMMs PowerPoint Slides
Morten Nielsen, CBS
- 10.00 - 10.15
- Coffee Break
- 10.15 - 11.00
- Prediction of MHC binding peptides using neural networks PowerPoint Slides
Morten Nielsen, CBS
- 11.15 - 12.00
- Selection of Epitopes using an integrative approach
Mette Voldby Larsen, CBS
- 12.00 - 13.00
- Lunch Break
- 13.00 - 16.00
-
- Exercises:
Prediction of T cell epitopes, Claus Lundegaard and Morten Nielsen, CBS
Wednesday, June 14
- Reading: Chapter 14
- 9.00 - 10.00
- Selection of potential HIV T-cell epitopes, Sheila Teng, CBS
- 10.00 - 10.15
- Coffee Break
- 10.15-11.00
- Vaccine design. PowerPoint Slides
Ole Lund, CBS
- 11.05 - 12.00
- Prediction of linear and conformational epitopes,power-point slides
Pernille Haste Andersen, CBS
- 12.00 - 13.00
- Lunch Break
- 13.00 - 16.00
- Exercises:
Prediction of B cell epitopes, Jens Erik Pontoppidan Larsen + Pernille Haste Andersen, CBS
Thursday, June 15
-
- 9.00 - 12.00
- Exersices:
Plasmid design, Vaccine design, Gene Atlases, Claus Lundegaard + Morten Nielsen, CBS
- 12.00 - 13.00
- Lunch Break
- 13.00 -
- Formation of groups and selection of subjects.
Friday, June 16 - Thursday, June 22: Project work and inwited speakers
Introduction to project work , Claus Lundegaard, Morten Nielsen and Ole Lund, CBS
Friday, June 16
- 9.00: DNA Vaccines.
Anneline Nansen, Statens Serum Institut (SSI).
Monday, June 19
- 9.00: Vaccination against allergy.
Ulla Seppälä, ALK-Abelló
Tuesday, June 20
- 9.00: The use of bioinformatics in the generation of recombinant polyclonal antibodies.
Peter Sejr Andersen, Ph.D., Symphogen A/S
Wednesday, June 21
- 9.00: TB Vaccines.
Dr. T. Mark Doherty, Statens Serum Institut.
Thursday, June 22
- 9.00: Reproductive Immunology or Why did your mother not reject you?
Thomas V. F. Hviid, Ph.D, Staff Specialist, Roskilde University Hospital
Friday, June 23
- Poster presentations, round up.
For more information, please contact Claus Lundegaard or Johanne Keiding . |
