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NESbase 1.0

Article abstract

NESbase version 1.0, a database of Nuclear Export Signals.
Tanja la Cour2,1, Ramneek Gupta1, Kristoffer Rapacki1,
Karen Skriver2, Flemming M. Poulsen2 and Søren Brunak1.

Nucleic Acids Res., 31(1):393-6, 2003.

1 Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark
2 Department of Protein Chemistry, Institute of Molecular Biology, University of Copenhagen, DK-1353 Copenhagen, Denmark

Protein export from the nucleus is often mediated by a Leucine-rich nuclear export signal. NESbase is a database of experimentally validated Leucine-rich Nuclear Export Signals (NES) curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each NESbase entry contains information of whether NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. The compiled information was used to make a sequence logo of the Leucine-rich NESs, displaying the conservation of amino acids within a window of 25 residues. Surprisingly, only 36% of the sequences used for the logo fit the widely accepted NES consensus L-x(2,3)-[LIVFM]-x(2,3)-L-x-[LI].


Ramneek Gupta,