Required reading: Chapter 1 & Appendix B, from Baldi and Brunak
Part 1: Nucleic acid
and protein sequence as information
Schrödinger and Morse Code Biological Sequence as Information A few words about the speed of DNA sequencing On the sizes of genomes and proteomes How to do a "blast search" of a DNA or protein sequence
Part 2: Complexity
and Genome Organisation: Implications for Sequence Analysis
A closer look at the sizes of genomes The "C-value" paradox Characterisation of Repetitive DNA Repetitive DNA can cause problems in sequence analysis
Also, you might want check out
an exam I gave my Genetics class last spring, which is based mainly
on doing blast searches.
"Official"
CBS Bioinformatics links
(an on-line and updated version of Chapter 12 from the Baldi &
Brunak book)
HMS Beagle report on NCBI Bioinformatics sites - this is a good place for a molecular biologist to start!
The "Gene Discovery Page" - another very good site with lots of links and explanations
The Human Genome Project Information page - this is put out by Los Alamos National Labs, and is updated regularly.
background on "The
Central Dogma of molecular biology"
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