Part 1: Chromosomal Localisation of DNA Structures

Outline:

Introduction: DNA Compaction in chromosomes (again!)

A Brief overview of eukaryotic chromosome architecture

Fragile X-syndrome and nucleosome positioning

Centromeric DNA

A few more words about curved DNA

yeast Autonomously Replicating Sequences

Human centromeric DNA

 

Telomeric DNA

Telomeric DNA Sequences

4-stranded DNA structures

Telomerase enzyme

Heterochromatin vs. Euchromatin

Heterochromatin and repetitive DNA sequences

Euchromatin and the organisation of genes

Part 2: Localisation of DNA Structures within Genes

Outline:

A comparison between Eukaryotic vs. Bacterial genes

 

Upstream regions of Eukaryotic genes

 

Introns and repetitive elements

 

Self-test QUIZ
 
 

LINKS:

References on DNA

"Official" CBS Bioinformatics links
(an on-line and updated version of Chapter 12 from the Baldi & Brunak book)
 
 

HMS Beagle report on NCBI Bioinformatics sites - this is a good place for a molecular biologist to start!

The "Gene Discovery Page" - another very good site with lots of links and explanations

The Human Genome Project Information page - this is put out by Los Alamos National Labs, and is updated regularly.

background on "The Central Dogma of molecular biology"
 
 

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