Biological Sequence Analysis - #27803 - INTERNET TRANSMISSION
Sequence Analysis Structure Prediction Biological Function
12 point PhD course, two week intensive course from May 2 to 13, 2011
Registration has now closed. Answers to applications will be sent on April 1, 2011.
A two week Ph.D. course will be held again from May 2 to 13, 2011 covering
biological macromolecules from sequence analysis
through 3D-structure to the understanding of biological function at the
molecular level. The course also involves aspects of systems biology,
analysis of protein-protein interaction data and data from transcriptomics
The course is offered in an on-site version as well as an internet transmitted version. The internet version of the course will be a combination of live,
real-time transmitted lectures and webbased exercises, where the
students will be introduced to a range of computational methods
used in the field and to internet biocomputing services available.
It will be possible to communicate and ask questions during the
lectures and exercises via chat lines maintained by CBS staff.
To apply for the course, please sign up through the online
application form which will be open from January 3, 2011. The application deadline is March 4, 2011.
The course will
be relevant for Ph.D. students within biochemistry, physics, chemistry
or molecular biology with an interest in DNA, RNA and/or proteins. The
following topics will be covered:
The course will consist of lectures and computer exercises,
where the students will be introduced to a range of computational methods used
in the field and to Internet biocomputing services available.
It is arranged by Center for Biological
Sequence Analysis at DTU Systems Biology.
- Nucleotide and amino acid sequences: advanced multiple alignment
database overview, gene finding, phylogeny reconstruction.
- Protein, RNA and DNA structure: prediction tools, artificial neural networks,
genetic algorithms, hidden Markov models, threading, structural alignment,
homology modelling, protein surface and secondary structure
prediction, DNA bending, RNA secondary structure.
- DNA microarrays: Analysis of DNA microarray data including normalization,
significance, clustering and principal component analysis.
- Protein and gene function:
protein dynamics, catalytic mechanisms, binding sites and
binding energies, docking,
energy minimization, structure based drug design, gene function prediction
For more information, contact Anders Gorm Pedersen or Dorthe Kjærsgaard