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Biological Sequence Analysis - #27803 - INTERNET TRANSMISSION

Sequence Analysis   Structure Prediction   Biological Function

12 point PhD course, two week intensive course from May 2 to 13, 2011


Registration has now closed. Answers to applications will be sent on April 1, 2011.

Course programme

A two week Ph.D. course will be held again from May 2 to 13, 2011 covering biological macromolecules from sequence analysis through 3D-structure to the understanding of biological function at the molecular level. The course also involves aspects of systems biology, analysis of protein-protein interaction data and data from transcriptomics experiments.

The course is offered in an on-site version as well as an internet transmitted version. The internet version of the course will be a combination of live, real-time transmitted lectures and webbased exercises, where the students will be introduced to a range of computational methods used in the field and to internet biocomputing services available. It will be possible to communicate and ask questions during the lectures and exercises via chat lines maintained by CBS staff.

To apply for the course, please sign up through the online application form which will be open from January 3, 2011. The application deadline is March 4, 2011.

The course will be relevant for Ph.D. students within biochemistry, physics, chemistry or molecular biology with an interest in DNA, RNA and/or proteins. The following topics will be covered:
  • Nucleotide and amino acid sequences: advanced multiple alignment methods, sequencing, database overview, gene finding, phylogeny reconstruction.

  • Protein, RNA and DNA structure: prediction tools, artificial neural networks, genetic algorithms, hidden Markov models, threading, structural alignment, homology modelling, protein surface and secondary structure prediction, DNA bending, RNA secondary structure.

  • DNA microarrays: Analysis of DNA microarray data including normalization, significance, clustering and principal component analysis.

  • Protein and gene function: protein dynamics, catalytic mechanisms, binding sites and binding energies, docking, energy minimization, structure based drug design, gene function prediction
The course will consist of lectures and computer exercises, where the students will be introduced to a range of computational methods used in the field and to Internet biocomputing services available. It is arranged by Center for Biological Sequence Analysis at DTU Systems Biology.

For more information, contact Anders Gorm Pedersen or Dorthe Kjærsgaard