Ph.D. course in Biological Sequence Analysis
March 31 to April 11, 2003
Sequence Analysis Structure Prediction Biological Function
A two week Ph.D. course will be held from March 31 to April 11, 2003 covering
biological macromolecules from sequence analysis through 3D-structure to
the understanding of biological function at the molecular level.
The course will
be relevant for Ph.D. students within biochemistry, physics, chemistry
or molecular biology with an interest in DNA, RNA and/or proteins. The
following topics will be covered:
The course will consist of lectures and computer exercises,
where the students will be introduced to a range of computational methods used
the field and to Internet biocomputing services available.
It is arranged by Center for Biological
Sequence Analysis at BioCentrum-DTU.
- Nucleotide and amino acid sequences: advanced multiple alignment
database overview, gene finding, phylogeny reconstruction.
- Protein, RNA and DNA structure: prediction tools, artificial neural networks,
genetic algorithms, hidden Markov models, threading, structural alignment,
homology modelling, protein surface and secondary structure
prediction, DNA bending, RNA secondary structure.
- DNA microarrays: Analysis of DNA microarray data including normalization,
significance, clustering, principal component analysis, reverse engineering of
regulatory networks and promoter analysis.
- Protein and gene function:
protein dynamics, catalytic mechanisms, binding sites and
binding energies, docking,
energy minimization, structure based drug design, gene function prediction
|Teachers will include:|| Søren Brunak|| Steen Knudsen|| Anders Krogh||Dave Ussery|| Anders G. Pedersen||Nikolaj Blom|
some guest lecturers |
A Biologist's Guide to Analysis of DNA Microarray Data.
by S. Knudsen (2002) will be available at
the DTU bookstore (building 101A).
For more information, contact Steen Knudsen or Johanne Keiding, or see: