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Integrative Systems Biology
Group leader: Søren Brunak
Members: Albert Pallejà Caro, Anders Boeck Jensen, Christian Gram Kalhauge, Helle Krogh Pedersen, Isa Kirk, Jens Friis-Nielsen, Jose Maria Gonzalez-Izarzugaza, Karine Audouze, Kasper Lage Hansen, Kirstine Christensen Belling, Kristine Grønning Kongsbak, Li Jiang, Mette Kristina Beck, Nikolaj Blom, Peter Løngreen, Piotr Dworzynski, Robert Eriksson, Sanna Herrgard, Tune Hannes Pers, Valborg Gudmundsdottir
Guest members: Agnieszka Sierakowska Juncker, Angela Re, Chris Workman, Hanne Østergaard Jarmer, Mette Voldby Larsen, Pope Moseley, Ramneek Gupta
Catalog of previous student projects.
News

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2008-Dec-28 This week, reseachers from the Integrative Systems Biology group at CBS have created a catalogue of tissue-specific processes involved in hundreds of inherited diseases. These results could help treat diseases such as breast cancer, Parkinson disease, heart diseases and autism, and is the result of a collaboration between CBS, Massachusetts General Hospital, and Harvard Medical School. Read more here:
[English Press release]
[Article in PNAS]
[Pubmed]
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2007-Mar-12 New research,
published in this weeks issue of Nature Biotechnology, show that genes
involved in the development of inherited diseases, such as Alzheimer's
disease, work together in protein complexes. This
knowledge has been used to predict new genes involved in hundreds of diseases
such as sclerosis and type 2-diabetes. Read more here:
[Danish Press release]
[Article in Nature Biotechnology]
[Pubmed]
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2006-Oct-5 This week, the Journal Nature publishes exciting new results from the Brunak and Bork
groups which reveal that despite the fact that many of the core cell cycle protein complexes are conserved during evolution, their regulation has
evolved considerably. The results are in perfect agreement with the just-in-time assembly principle that we proposed last year for yeast and even
demonstrate a hitherto undescribed tendency for co-evolution of different layers of regulation. Read more here:
[Danish Press release]
[Article in Nature]
[Commentary in Nature]
[Pubmed]
[Supplementary Information]
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2006-Apr-21 New work published in the international journal Molecular Cell provides insight into
the composition and function of the human subcellular structure known as the Nucleolus. The work is a prime example of how integration of already
published biological data can be analyzed to reveal novel aspects, not visible from any single type of data alone. Read more here:
[Molecular Cell]
[PubMed]
[Supplementary Information]
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2005-Feb-4 The international journal Science today publishes new insight into the systemic aspect of cell cycle regulation in the model
organism, bakers yeast. The research, which has been conducted in collaboration with Lars Juhl Jensen and Peer Bork of the European Molecular
Biology Laboratory in Heidelberg, reveals that only some subunits of protein complexes are regulated during the cell cycle, but always such that the regulation
ensures assembly of the functional complex just-in-time for action. Read more here:
[Press release]
[Commentary in Nature Reviews]
[Science Magazine]
[PubMed]
[Supplementary Information]
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About the group
The group is interested in understanding how cells and molecular processes function and play together as systems. Our focus is thus not on
individual genes or proteins, but rather on how the interplay between many components create modules and systems, and how defects in these
modules can lead to human disease. The group members are constantly working on finding novel ways of integrating experimental and predicted
data on coding and non-coding sequence, structure, localization, modification, function, expression, pathways, and interaction to ellucidate
complex biological mechanisms. The group is highly interdisciplinary and includes biologists, engineers, pharmacists, physicists, programmers,
and disease experts.
Current areas of interest include:
- Finding new genes and protein modules involved in human disease
- Uncovering how cell division is regulated in different organism
- Elucidating how cancer affects the cell at a systemic level
- Understanding cellular regulation and its evolution from a systems perspective
- Studying the extent and impact of alternative splicing
If you are interested in learning more about the group or our work, please contact the group coordinator
Thomas Skøt Jensen.
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Selected Publications
- A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes
Lage K, Hansen NT, Karlberg EO, Eklund AC, Roque FS, Donahoe PK, Szallasi Z, Jensen TS, Brunak S.
Proc Natl Acad Sci U S A. 105(52):20870-5, 2008. PMID: 19104045
- A human phenome-interactome network of protein complexes implicated in genetic disorders
K. Lage, E.O. Karlberg, Z.M. Storling, P.I. Olason, A.G. Pedersen, O. Rigina, A.M. Hinsby, Z. Tumer, F. Pociot, N. Tommerup, Y. Moreau, S. Brunak
Nature Biotechnology, 25(3):309-16, 2007. PMID: 17344885
- Co-evolution of transcriptional and posttranslational cell cycle regulation
L.J. Jensen, T.S. Jensen, U. de Lichtenberg, S. Brunak and P. Bork
Nature, 2006. PMID: 17006448
- A Wiring of the Human Nucleolus
A.M Hinsby, L. Kiemer, E.O. Karlberg, K. Lage, A. Fausbøll, A.S. Juncker, J.S. Andersen, M. Mann and S. Brunak
Molecular Cell, 22, 285-295, 2006. PMID: 16630896
- Dynamics of complex formation during the yeast cell cycle
U. de Lichtenberg, L.J. Jensen, S. Brunak and P. Bork
Science, 307(5709), Feb 4., 2005. PMID:15692050
- Protein feature based identification of cell cycle regulated proteins in yeast
U. de Lichtenberg, T.S. Jensen, L.J. Jensen and S. Brunak
Journal of Molecular Biology, 329, 663-74, 2003. PMID: 12787668
- Prediction of human protein function from post-translational modifications and localization features
L.J. Jensen, R. Gupta, N. Blom, D. Devos, J. Tamames, C. Kesmir, H. Nielsen, H.H. Stærfeldt,
K. Rapacki, C. Workman, C. A. F. Andersen, S. Knudsen, A. Krogh, A. Valencia and S. Brunak
Journal of Molecular Biology, 319, 1257-1265, 2002. PMID: 12079362
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Full list of CBS publications
Internal ISB Wiki
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