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Nutritional Immunology

Catalog of previous student projects.

Strategies for Prevention of Life-Style Diseases

Nearly all diseases of affluence (obesity, diabetes T2, coronary heart disease, inflammatory bowel diseases, allergies, etc.) are associated with or are caused by a dysregulated immune response. We aim to provide insight into immunological mechanisms leading to these diseases and to develop nutritional strategies for prevention. To this end, two different strategies are pursued:

  • Increasing resistance to infections through enhancement of host responses and integrity of (intestinal) barriers.

  • Fighting inflammatory diseases through nutritional control of immune-regulating cells and appropriate immune maturation during childhood.
An appropriate regulation can only be achieved by regarding the systemic interaction of all components participating in the regulation of the local and systemic immune response as shown in the figure to the right.

Models for investigation of effects and molecular mechanisms are animal models and cell lines where proteomics, transcriptomics, and lipidomics are applied.