Catalog of previous student projects.
Strategies for Prevention of Life-Style Diseases|
Nearly all diseases of affluence (obesity, diabetes T2, coronary heart disease, inflammatory bowel diseases, allergies, etc.)
are associated with or are caused by a dysregulated immune response. We aim to provide insight into immunological mechanisms
leading to these diseases and to develop nutritional strategies for prevention. To this end, two different strategies are
An appropriate regulation can only be achieved by regarding the systemic interaction of all components participating in
the regulation of the local and systemic immune response as shown in the figure to the right.
- Increasing resistance to infections through enhancement of host responses and integrity
of (intestinal) barriers.
- Fighting inflammatory diseases through nutritional control of immune-regulating cells and
appropriate immune maturation during childhood.
Models for investigation of effects and molecular mechanisms are animal models and cell lines where proteomics,
transcriptomics, and lipidomics are applied.