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Article abstract


Prediction of novel archaeal enzymes from sequence-derived features.
Jensen LJ, Skovgaard M, Brunak S.
Protein Science: 11: 2894-2898, 2002.

Center for Biological Sequence Analysis, BioCentrum-DTU, The Technical University of Denmark, DK-2800 Lyngby, Denmark


The completely sequenced archaeal genomes potentially encode, among their many functionally uncharacterized genes, novel enzymes of biotechnological interest. We have developed a prediction method for detection and classification of enzymes from sequence alone (available at The method does not make use of sequence similarity; rather, it relies on predicted protein features like cotranslational and posttranslational modifications, secondary structure, and simple physical/chemical properties.


Lars Juhl Jensen,