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Cofactory v.1.0 - Identification of Rossmann folds and prediction of FAD, NAD and NADP specificity

Cofactory is a server that identifies Rossmann fold sequence domains and predicts their specificity for the cofactors FAD, NAD or NADP.

Instructions Output format Paper abstract


Paste a single amino acid sequence or several sequences in FASTA format into the field below:

Submit a file in FASTA format directly from your local disk:

At most 2,000 sequences and 200,000 amino acids per submission; each sequence not more than 6,000 amino acids.

The sequences are kept confidential and will be deleted after processing.


For publication of results, please cite:

Cofactory: Sequence-based prediction of cofactor specificity of Rossmann folds.

Geertz-Hansen HM, Blom N, Feist AM, Brunak S, Petersen TN.
Proteins. 2014 Feb 13. doi: 10.1002/prot.24536


Would you prefer to run Cofactory at your own site? Cofactory 1.0 is available as a stand-alone software package, with the same functionality as the service above. Ready-to-ship packages exist for the most common UNIX platforms. There is a download page for academic users; other users are requested to contact CBS at


Scientific problems:        Technical problems: