DiscoTope 2.0 Server
DiscoTope server predicts discontinuous B cell epitopes from protein
three dimensional structures. The method utilizes calculation of surface
accessibility (estimated in terms of contact numbers) and a novel epitope
propensity amino acid score. The final scores are calculated by combining
the propensity scores of residues in spatial proximity and the contact
New in the DiscoTope version 2.0: Novel definition of the spatial neighborhood
used to sum propensity scores and half-sphere exposure as a surface measure.
The DiscoTope server has been up-dated to improve the user-friendliness.
The server now predicts epitopes in complexes of multiple chains. Also, DiscoTope
output files are now easily downloaded and imported in spreadsheets. Futhermore,
we have facilitated the visualization of prediction results.
For publication of results, please cite:
Reliable B Cell Epitope Predictions: Impacts of Method Development and Improved Benchmarking
Jens Vindahl Kringelum, Claus Lundegaard, Ole Lund, and Morten Nielsen
Plos Computational Biology, 2012
Link to Paper
Would you prefer to run DiscoTope at your own site? The DiscoTope 2.0
software package is in preparation; in the meanwhile an earlier version
(1.1) is available as a stand-alone software package, with the same
functionality as the
DiscoTope 1.1 server online.
Ready-to-ship packages exist for the most common UNIX platforms. There
for academic users; other users are requested to contact CBS Software Package
Manager at firstname.lastname@example.org.