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Thermotogae
Classification of phyla is from NCBI page
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264 projects found  

2 accessions found for Escherichia coli O157:H7 EDL933  

Data for AE005174  

Available Atlases
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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: AE005174.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
AE005174_3665 CDS_3704754-3707510 100.1 6.5e-28 1
AE005174_0446 CDS_479872-481167 91.0 2.6e-25 1
AE005174_3261 CDS_3282470-3286063 81.6 1.1e-22 1
AE005174_1240 CDS_1319318-1316604 80.7 2e-22 1
AE005174_3119 CDS_3124084-3121283 80.6 2.3e-22 1
AE005174_4110 CDS_4162595-4160259 78.9 6.9e-22 1
AE005174_3436 CDS_3481365-3479875 75.4 6.7e-21 1
AE005174_2907 CDS_2908528-2909931 69.8 2.6e-19 1
AE005174_4871 CDS_4973699-4972326 66.7 1.9e-18 1
AE005174_5345 CDS_5523489-5524913 62.4 3.1e-17 1
AE005174_4966 CDS_5079497-5080873 61.5 5.8e-17 1
AE005174_0603 CDS_677212-675764 61.0 8e-17 1
AE005174_3926 CDS_3977227-3978576 60.7 1e-16 1
AE005174_4824 CDS_4921014-4919965 59.7 1.9e-16 1
AE005174_0716 CDS_802624-799940 59.6 2e-16 1
AE005174_4271 CDS_4315284-4313932 55.0 4e-15 1
AE005174_2747 CDS_2737905-2736547 52.3 2.2e-14 1
AE005174_5077 CDS_5217706-5216615 45.0 2.7e-12 1
AE005174_2362 CDS_2357969-2359270 42.4 1.5e-11 1
AE005174_5055 CDS_5196438-5198708 36.1 9.1e-10 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
AE005174_3665 1/1 292 357 .. 1 87 [] 100.1 6.5e-28
AE005174_0446 1/1 203 269 .. 1 87 [] 91.0 2.6e-25
AE005174_3261 1/1 711 777 .. 1 87 [] 81.6 1.1e-22
AE005174_1240 1/1 433 498 .. 1 87 [] 80.7 2e-22
AE005174_3119 1/1 453 518 .. 1 87 [] 80.6 2.3e-22
AE005174_4110 1/1 282 347 .. 1 87 [] 78.9 6.9e-22
AE005174_3436 1/1 270 338 .. 1 87 [] 75.4 6.7e-21
AE005174_2907 1/1 240 304 .. 1 87 [] 69.8 2.6e-19
AE005174_4871 1/1 238 300 .. 1 87 [] 66.7 1.9e-18
AE005174_5345 1/1 255 320 .. 1 87 [] 62.4 3.1e-17
AE005174_4966 1/1 237 303 .. 1 87 [] 61.5 5.8e-17
AE005174_0603 1/1 261 327 .. 1 87 [] 61.0 8e-17
AE005174_3926 1/1 236 302 .. 1 87 [] 60.7 1e-16
AE005174_4824 1/1 129 186 .. 1 79 [. 59.7 1.9e-16
AE005174_0716 1/1 663 730 .. 1 87 [] 59.6 2e-16
AE005174_4271 1/1 233 293 .. 1 87 [] 55.0 4e-15
AE005174_2747 1/1 235 301 .. 1 87 [] 52.3 2.2e-14
AE005174_5077 1/1 142 202 .. 1 87 [] 45.0 2.7e-12
AE005174_2362 1/1 211 271 .. 1 87 [] 42.4 1.5e-11
AE005174_5055 1/1 400 462 .. 1 87 [] 36.1 9.1e-10

Alignments of top-scoring domains:
AE005174_3665: domain 1 of 1, from 292 to 357: score 100.1, E = 6.5e-28
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g++ l l+ tel++ q
AE005174_3 292 IKSEFLANMSHELRTPLNGVIGFTRLTLK---------TELTPTQ-- 327

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ti+r+a+ ll++ind+Ld+s++eag
AE005174_3 328 ----------RDHLNTIERSANNLLAIINDVLDFSKLEAG 357

AE005174_0446: domain 1 of 1, from 203 to 269: score 91.0, E = 2.6e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ f+an+sHELRTPLt+++gy+e++ e ++l r
AE005174_0 203 ARRNFFANVSHELRTPLTVLQGYLEMMDE---------QPLEGAVR- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l+t++++++r++ L+ +lL+ls+iea
AE005174_0 240 ----------EKALHTMREQTQRMEGLVKQLLTLSKIEAA 269

AE005174_3261: domain 1 of 1, from 711 to 777: score 81.6, E = 1.1e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla++sHE+RTP+++I+g++elL + ls eqr
AE005174_3 711 AKSQFLATMSHEIRTPISSIMGFLELLSG---------SGLSKEQR- 747

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ ++ +++ll Li ++Ld +ie+g
AE005174_3 748 ----------VEAISLAYATGQSLLGLIGEILDVDKIESG 777

AE005174_1240: domain 1 of 1, from 433 to 498: score 80.7, E = 2e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks fla++sHE+RTPL +I+g+a+lL + ++ q
AE005174_1 433 AKSAFLAAMSHEIRTPLYGILGTAQLLAD---------NPALNAQ-- 468

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ i +++e+ll ++nd+Ld+s ieag
AE005174_1 469 ----------RDDLRAITDSGESLLTILNDILDYSAIEAG 498

AE005174_3119: domain 1 of 1, from 453 to 518: score 80.6, E = 2.3e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks fla++sHELRTPL +I+g+++lL++ el+
AE005174_3 453 SKSMFLATVSHELRTPLYGIIGNLDLLQT---------KELPKGV-- 488

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + +++ ll++i+d+Ld+s+ie++
AE005174_3 489 ----------DRLVTAMNNSSSLLLKIISDILDFSKIESE 518

AE005174_4110: domain 1 of 1, from 282 to 347: score 78.9, E = 6.9e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+ f++++sHELRTPL++I g++ +Ll+ tel++eq
AE005174_4 282 DKTTFISTISHELRTPLNGIVGLSRILLD---------TELTAEQ-- 317

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+ti+ +a l ++ nd+ d+ ++e
AE005174_4 318 ----------EKYLKTIHVSAVTLGNIFNDIIDMDKMERR 347

AE005174_3436: domain 1 of 1, from 270 to 338: score 75.4, E = 6.7e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +fl++lsHEL+TPL+++r +elL +++ ++l++eq
AE005174_3 270 QRHQFLRHLSHELKTPLASMREGTELLADQV------VGPLTPEQ-- 308

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e +++++++++ l++Li++lLd+ r +a
AE005174_3 309 ----------KEVVSILDSSSRNLQKLIEQLLDYNRKQAD 338

AE005174_2907: domain 1 of 1, from 240 to 304: score 69.8, E = 2.6e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+a++sHELRTPL+++rg +e++++++ + ++e+
AE005174_2 240 MRRDFMADISHELRTPLAVLRGELEAIQDGV-------RKFTPET-- 277

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +++ e+ l +L++dl +ls ++g
AE005174_2 278 -------------VASLQAEVGTLTKLVDDLHQLSMSDEG 304

AE005174_4871: domain 1 of 1, from 238 to 300: score 66.7, E = 1.9e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++++l+++sHELRTPLt +++ + lL++ +++
AE005174_4 238 SQQRLLSDISHELRTPLTRLQLGTALLRR---------RXGESKE-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i+ ea+rl+++indlL +sr ++
AE005174_4 274 -------------LERIETEAQRLDSMINDLLVMSRNQQK 300

AE005174_5345: domain 1 of 1, from 255 to 320: score 62.4, E = 3.1e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + +l HEL+ PL+aIrg+ae+L+e ++ +e
AE005174_5 255 YIEQYVYALTHELKSPLAAIRGAAEILRE---------GPPPEVV-- 290

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++++ il + r+++L++ lL +r+e+
AE005174_5 291 ----------ARFTDNILTQNARMQALVETLLRQARLENR 320

AE005174_4966: domain 1 of 1, from 237 to 303: score 61.5, E = 5.8e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++a+++HE+R+PL++I+g+a+ e +++++ e
AE005174_4 237 ALGHLAAGVAHEIRNPLSSIKGLAKYFAE--------RAPAGGEA-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ +++ +ea+rl+r +++lL+l + +
AE005174_4 274 ----------HQLAQVMAKEADRLNRVVSELLELVKPTHL 303

AE005174_0603: domain 1 of 1, from 261 to 327: score 61.0, E = 8e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s f a+++HE+RTP+t +++ +e++l + +s +++
AE005174_0 261 RQSNFSADIAHEIRTPITNLITQTEIALS---------QSRSQKEL- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e+ r+ ++++d+L l++++++
AE005174_0 298 ----------EDVLYSNLEELTRMAKMVSDMLFLAQADNN 327

AE005174_3926: domain 1 of 1, from 236 to 302: score 60.7, E = 1e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++f+++++HELR PLta++ +e+++ ++ +++ r
AE005174_3 236 RERRFTSDAAHELRSPLTALKVQTEVAQL---------SDDDPQAR- 272

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++ ++r rL+++lL+lsr+++
AE005174_3 273 ----------KKALLQLHSGIDRATRLVDQLLTLSRLDSL 302

AE005174_4824: domain 1 of 1, from 129 to 186: score 59.7, E = 1.9e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++++l+HE+++PL ++rg+a+lL + +l+++ +
AE005174_4 129 AARDLVRGLAHEIKNPLGGLRGAAQLLSK----------ALPDPSL- 164

peLRledpeyreyletilreaerllrLindlL<-*
ey+++i+++a+rl++L+++lL
AE005174_4 165 ----------LEYTKVIIEQADRLRNLVDRLL 186

AE005174_0716: domain 1 of 1, from 663 to 730: score 59.6, E = 2e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +la+lsH+LRTPLt++ g ae+L +l + ++++
AE005174_0 663 IRNALLAALSHDLRTPLTVLFGQAEILTLDL-------ASEGSPH-- 700

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ + i++ + rL+n+lLd++ri++g
AE005174_0 701 ----------ARQASEIRQHVLNTTRLVNNLLDMARIQSG 730

AE005174_4271: domain 1 of 1, from 233 to 293: score 55.0, E = 4e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ ++a++sH+LRTPLt Ir+++e++ e ++
AE005174_4 233 DRTLLMAGVSHDLRTPLTRIRLATEMMSE---------QD------- 263

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e+i +++e ++++i+++ d+ r +++
AE005174_4 264 ----------GYLAESINKDIEECNAIIEQFIDYLRTGQE 293

AE005174_2747: domain 1 of 1, from 235 to 301: score 52.3, E = 2.2e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s+f+ +l+HELRTP++a++g ++ l +++s +
AE005174_2 235 RLSQFADDLAHELRTPINALLGQNQVTLS---------QTRSIAE-- 270

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y++ + ++e+e ++rL +++L l+r++ +
AE005174_2 271 ---------YQKTIAGNIEELENISRLTENILFLARADKN 301

AE005174_5077: domain 1 of 1, from 142 to 202: score 45.0, E = 2.7e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+++r+++elL + t+
AE005174_5 142 NERLFTADVAHELRTPLAGVRLHLELLAK---------TH------- 172

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + ++++ + +++lL+l+r+++
AE005174_5 173 ----------HIDVAPLVARLDQMMESVSQLLQLARAGQS 202

AE005174_2362: domain 1 of 1, from 211 to 271: score 42.4, E = 1.5e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k +++ +++HELRTPL +r +e+ + ls+ +
AE005174_2 211 SKKQLIDGIAHELRTPLVRLRYRLEMSDN-----------LSAAE-- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + r++ +l++Li++lL+++r++ +
AE005174_2 245 -------------SQALNRDISQLEALIEELLTYARLDRP 271

AE005174_5055: domain 1 of 1, from 400 to 462: score 36.1, E = 9.1e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++ +l+H++++ L++I+g +el + +++
AE005174_5 400 AVGQLTGGLAHDFNNLLAVIIGSLELVNP---------DSPDAPR-- 435

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++l++aer L ++lL +sr ++
AE005174_5 436 -------------IQRALQAAERGALLTQRLLAFSRKQSL 462


Histogram of all scores:
score obs exp (one = represents 18 sequences)
----- --- ---
-16 3 0|=
-15 15 0|=
-14 34 0|==
-13 103 4|*=====
-12 296 122|======*==========
-11 532 634|============================== *
-10 923 1176|==================================================== *
-9 1032 1214|==========================================================*
-8 879 909|================================================= *
-7 619 573|===============================*===
-6 380 329|==================*===
-5 227 180|=========*===
-4 121 96|=====*=
-3 63 51|==*=
-2 29 26|=*
-1 38 14|*==
0 15 7|*
1 7 3|*
2 7 1|*
3 3 1|*
4 0 0|
5 1 0|=
6 0 0|
> 7 22 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 427.3647
P(chi-square) = 0

Total sequences searched: 5349

Whole sequence top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 28K


Acknowledgements:

This research is funded by:

Developed by: