Acidobacteria Actinobacteria Alphaproteobacteria
Aquificae Bacteroidetes/Chlorobi Betaproteobacteria
Chlamydiae/Verrucomicrobia Chloroflexi Cyanobacteria
Deinococcus-Thermus Deltaproteobacteria Epsilonproteobacteria
Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
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19 projects found  

2 accessions found for Leptospira interrogans serovar Lai str. 56601  

Data for AE010300  

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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: AE010300.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
AE010300_2221 CDS_2203802-2206300 124.7 5.8e-35 2
AE010300_3992 CDS_3969858-3967396 99.0 1.1e-27 1
AE010300_2540 CDS_2525427-2528234 94.1 2.8e-26 1
AE010300_3659 CDS_3612959-3615049 93.0 5.7e-26 1
AE010300_3855 CDS_3821522-3822844 92.3 8.6e-26 1
AE010300_4101 CDS_4070087-4071478 86.2 4.8e-24 1
AE010300_2420 CDS_2390567-2392762 81.5 9.9e-23 1
AE010300_1744 CDS_1733955-1737578 76.0 3.5e-21 1
AE010300_2548 CDS_2535842-2534721 66.9 1.3e-18 1
AE010300_1347 CDS_1342726-1341338 61.0 6.3e-17 1
AE010300_1745 CDS_1737592-1738707 60.3 1e-16 1
AE010300_1527 CDS_1526376-1527842 57.5 6.4e-16 1
AE010300_2222 CDS_2206339-2207487 54.5 4.4e-15 1
AE010300_1692 CDS_1692890-1691757 50.9 4.7e-14 1
AE010300_3106 CDS_3090940-3088328 49.6 1.1e-13 1
AE010300_3892 CDS_3863960-3861636 43.4 6.2e-12 1
AE010300_2400 CDS_2371547-2369757 43.0 8.1e-12 1
AE010300_2011 CDS_1989619-1990944 42.7 9.9e-12 1
AE010300_1709 CDS_1704195-1703440 37.6 2.8e-10 1
AE010300_2829 CDS_2814249-2813122 37.3 3.3e-10 1
AE010300_3891 CDS_3861607-3860084 37.0 4.2e-10 1
AE010300_2827 CDS_2812688-2811183 28.7 9e-08 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
AE010300_3992 1/1 434 499 .. 1 87 [] 99.0 1.1e-27
AE010300_2540 1/1 422 487 .. 1 87 [] 94.1 2.8e-26
AE010300_3659 1/1 323 388 .. 1 87 [] 93.0 5.7e-26
AE010300_3855 1/1 67 132 .. 1 87 [] 92.3 8.6e-26
AE010300_4101 1/1 232 300 .. 1 87 [] 86.2 4.8e-24
AE010300_2221 1/2 208 274 .. 1 87 [] 83.1 3.5e-23
AE010300_2420 1/1 342 407 .. 1 87 [] 81.5 9.9e-23
AE010300_1744 1/1 550 618 .. 1 87 [] 76.0 3.5e-21
AE010300_2548 1/1 148 214 .. 1 87 [] 66.9 1.3e-18
AE010300_1347 1/1 238 306 .. 1 87 [] 61.0 6.3e-17
AE010300_1745 1/1 152 220 .. 1 87 [] 60.3 1e-16
AE010300_1527 1/1 274 340 .. 1 87 [] 57.5 6.4e-16
AE010300_2222 1/1 151 217 .. 1 87 [] 54.5 4.4e-15
AE010300_1692 1/1 152 220 .. 1 87 [] 50.9 4.7e-14
AE010300_3106 1/1 648 716 .. 1 87 [] 49.6 1.1e-13
AE010300_3892 1/1 549 616 .. 1 87 [] 43.4 6.2e-12
AE010300_2400 1/1 365 437 .. 1 87 [] 43.0 8.1e-12
AE010300_2011 1/1 223 286 .. 1 87 [] 42.7 9.9e-12
AE010300_2221 2/2 606 674 .. 1 87 [] 41.6 2.1e-11
AE010300_1709 1/1 31 99 .. 1 87 [] 37.6 2.8e-10
AE010300_2829 1/1 150 217 .. 1 87 [] 37.3 3.3e-10
AE010300_3891 1/1 288 354 .. 1 87 [] 37.0 4.2e-10
AE010300_2827 1/1 153 219 .. 1 87 [] 28.7 9e-08

Alignments of top-scoring domains:
AE010300_3992: domain 1 of 1, from 434 to 499: score 99.0, E = 1.1e-27
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ks flan+sHE+RTP+++++g+++lL + t+l++eq
AE010300_3 434 VKSNFLANMSHEIRTPMNGVLGMVQLLGT---------TKLNDEQ-- 469

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ey+e++ +a++ll++ind+Ld+s+ieag
AE010300_3 470 ----------KEYVEVLSVSAKSLLQIINDILDFSKIEAG 499

AE010300_2540: domain 1 of 1, from 422 to 487: score 94.1, E = 2.8e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ak++fla++sHE+RTPL++++g+++lL+ t l+ eq
AE010300_2 422 AKTDFLAMMSHEIRTPLNGVIGTVSLLEG---------TFLNTEQ-- 457

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+eyl++i+++++ ll L+nd+Ldlsrie+g
AE010300_2 458 ----------KEYLDIIKSSGQNLLILLNDILDLSRIESG 487

AE010300_3659: domain 1 of 1, from 323 to 388: score 93.0, E = 5.7e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ak+ f++n+sHE+RTP+t+I+g +elLl+ t+l+++q
AE010300_3 323 AKTVFISNISHEIRTPMTGILGITELLLN---------TPLNPDQ-- 358

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ le i+r+++ ll+++n lLd+s++++g
AE010300_3 359 ----------KDSLELIQRSGDKLLKIVNHLLDFSKADTG 388

AE010300_3855: domain 1 of 1, from 67 to 132: score 92.3, E = 8.6e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks f+an+sHE+RTP+++I+g + lL e tel eq
AE010300_3 67 SKSLFFANMSHEIRTPVHGILGVSGLLSE---------TELQQEQ-- 102

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ey++ti+r+++ ll+L+nd+Ld+s++e+
AE010300_3 103 ----------KEYVDTIQRSGKLLLNLLNDILDFSKLESF 132

AE010300_4101: domain 1 of 1, from 232 to 300: score 86.2, E = 4.8e-24
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++f+ n+sHEL+TP+t+I+gy+e+Ll+ + ls+e +
AE010300_4 232 IREQFVQNASHELKTPITSIKGYTETLLD--------RLRLSPESHE 270

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l+ i r ++r+ r+++d+L+++rie++
AE010300_4 271 ----------KRFLDAISRNTDRMVRIVEDMLTITRIENQ 300

AE010300_2221: domain 1 of 2, from 208 to 274: score 83.1, E = 3.5e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ks+f+an+sHELRTPLt I+g + +Ll+ d+ ++ q
AE010300_2 208 LKSQFFANVSHELRTPLTLILGPTRALLK--------DQGITSTQ-- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r +leti+r + ll+ +ndlLdls++++g
AE010300_2 245 ----------RTFLETIERNSYTLLKHVNDLLDLSKLDSG 274

AE010300_2420: domain 1 of 1, from 342 to 407: score 81.5, E = 9.9e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
akseflan+sHELRTPL++I+g++ l++ +e e +
AE010300_2 342 AKSEFLANMSHELRTPLNSIIGFSRLMQF---------PEGMERE-- 377

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+yl+ i +++ +ll++ind+Ldlsriea
AE010300_2 378 ----------NRYLDLIFHSGVHLLNIINDILDLSRIEAD 407

AE010300_1744: domain 1 of 1, from 550 to 618: score 76.0, E = 3.5e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++ +++ L + ++ +lse+q
AE010300_1 550 YKSEFLANMSHELRTPLNSLLILSKDLAD------NKRKNLSEDQ-- 588

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e ++i+++++ ll Lind+Ldls+ie+g
AE010300_1 589 ----------VESANIIYKSGHDLLVLINDVLDLSKIESG 618

AE010300_2548: domain 1 of 1, from 148 to 214: score 66.9, E = 1.3e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + + a+++HE+++PL +++ yae++ + + + +
AE010300_2 148 AIGTLSAGVAHEINNPLMGVINYAEMMVN---------GIENGNPL- 184

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+y +ilre++r+++++ d+L+++rie +
AE010300_2 185 ----------RKYAGIILREGNRISEIVKDMLTFTRIEKE 214

AE010300_1347: domain 1 of 1, from 238 to 306: score 61.0, E = 6.3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ f ++sH+LR P+ +I+g++++Lle + ++e r
AE010300_1 238 DLEAFSYSVSHDLRSPIRGILGFSKILLE----------DHGAELRE 274

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ r+++++i+r +e + +Li+dlL++sr++
AE010300_1 275 DS--------RRIVNIIIRNSENMGKLIDDLLEYSRLGRR 306

AE010300_1745: domain 1 of 1, from 152 to 220: score 60.3, E = 1e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++ f+ ++sH+L+ PL aIrgy+++L+e+++ ++ +ee
AE010300_1 152 ELDAFTYSVSHDLKAPLRAIRGYTKILKEDYE------EKFDEEG-- 190

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l i++ + +++Li+ lL ls+++
AE010300_1 191 ----------KRVLGLIIDNSLKMSSLIDSLLLLSKLGKK 220

AE010300_1527: domain 1 of 1, from 274 to 340: score 57.5, E = 6.4e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++++a+l+HE+++PL +I+ y +++++ ++ ++ ++
AE010300_1 274 SIQKLAAGLAHEINNPLMGIINYGHVIQN---------HKGGDAET- 310

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ y + i++++er+ ++i++l +s+ + +
AE010300_1 311 ----------KNYARLIIEQGERIAAIIRNLVLFSKKDPE 340

AE010300_2222: domain 1 of 1, from 151 to 217: score 54.5, E = 4.4e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++ +++HE+++PL aI+ ya ++ + +e ++e++
AE010300_2 151 AMGVMAGTMAHEINNPLIAISEYAAMIAK---------GEVDSEKA- 187

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ ++i++e+ r++ + +lL +sr + g
AE010300_2 188 ----------KQLASKIRDESARISTIMKNLLRFSRDDKG 217

AE010300_1692: domain 1 of 1, from 152 to 220: score 50.9, E = 4.7e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++ f+++++HEL++PLt+++++++ Ll++l t +++
AE010300_1 152 SLGIFISGVAHELNNPLTGMSLTLQSLLNNL-------TSIDPDF-- 189

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+r+ l+ +++++ r ++ d+ +++ +
AE010300_1 190 ---------FRKRLDMMKEDLTRAAMIVTDIISFAKPDRL 220

AE010300_3106: domain 1 of 1, from 648 to 716: score 49.6, E = 1.1e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ + +lsHEL+TPL++Irg++ +Lle +e
AE010300_3 648 LYTIIFNSLSHELKTPLSSIRGAVTALLE---------PEIENSR-- 683

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+R e+l+ i +++ l+ L+ +lLd+sr e+g
AE010300_3 684 -EAR------VELLNEINESSMILNLLLGNLLDMSRYESG 716

AE010300_3892: domain 1 of 1, from 549 to 616: score 43.4, E = 6.2e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +e++a+++HE ++PL a ++y+e L e +e ++ +r
AE010300_3 549 SIGELAAGIAHEVNNPLQASLLYLEELIE--------TEESDPAER- 586

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ ++i+ ++ r+++Li lLdl r a
AE010300_3 587 ----------LKIYKRIEAASVRIRDLIKSLLDLGRTVAR 616

AE010300_2400: domain 1 of 1, from 365 to 437: score 43.0, E = 8.1e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a e + ++HE+++PLt I++ ae +++++ + eq
AE010300_2 365 AWKEVAQRMAHEIKNPLTPIQLSAERIRRKM-------NSENKEQ-- 402

peLRledpeyreyl....etilreaerllrLindlLdlsrieag<-*
+ e+++++++ti+++++ l++L+n++ d++r+ a+
AE010300_2 403 ---------FYEIVssgtDTIIKQVRVLEHLVNEFSDFARMPAP 437

AE010300_2011: domain 1 of 1, from 223 to 286: score 42.7, E = 9.9e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ + ++ HE++ PL+++++ +el+ e +++ +
AE010300_2 223 YVENYVQSMTHEIKSPLSSLLASSELIIE------------NPDRL- 256

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +++ i+ e++r++ +++ lL+ls +e++
AE010300_2 257 ----------ESLVSNIQLEGRRIQTILEKLLELSSLENQ 286

AE010300_2221: domain 2 of 2, from 606 to 674: score 41.6, E = 2.1e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ f ++sH+LR P+ +I g+++++le++ ++++++e
AE010300_2 606 DMESFSYSVSHDLRAPILVIEGFLQIILEDF------SEKMDPEA-- 644

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ l+++++ + ++++Li+dlL + +
AE010300_2 645 ----------LRSLKIVHKNVVYMNHLIQDLLSFHKVSKI 674

AE010300_1709: domain 1 of 1, from 31 to 99: score 37.6, E = 2.8e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+ +sH+L PL +++ y+++L+e++ + ++
AE010300_1 31 ELEQFAFLASHDLQEPLRTVSNYIQVLEEDYG------NTFDSNA-- 69

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+yl+ti+++++r++ L+ lL ++ri+
AE010300_1 70 ----------TRYLKTIDQATKRMSVLVKALLMYARIGRD 99

AE010300_2829: domain 1 of 1, from 150 to 217: score 37.3, E = 3.3e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++f+ +sH+L PL I+++ + Ll+ + ++l++e
AE010300_2 150 DLEDFAFIASHDLQEPLRKIMAFGDRLLK-------KNSNLDSES-- 187

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+yl++++++a rl++Li+ lL +sri +
AE010300_2 188 ----------MDYLQRMYSSACRLSNLIEGLLSYSRIKSK 217

AE010300_3891: domain 1 of 1, from 288 to 354: score 37.0, E = 4.2e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+s +++++ HE+++ LtaI+g++e+++ ++++++ r
AE010300_3 288 FLSILASSIGHEINNSLTAIQGHIEIAKL---------PDATDPIR- 324

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++++ +++ l L n+lL+l + +++
AE010300_3 325 ----------QKAIQITWSQLVKLKTLTNNLLQLGKPGEN 354

AE010300_2827: domain 1 of 1, from 153 to 219: score 28.7, E = 9e-08
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
s+f +++H++++ L+ I +++++L++ ++ +++
AE010300_2 153 IISQFSGGVAHDFNNILNIIVANLDILEM---------KCKDQPEV- 189

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++++++ r + lL +sr ++
AE010300_2 190 ----------LNRIQSAQNAVLRGAEVNKKLLNFSRKQSL 219


Histogram of all scores:
score obs exp (one = represents 13 sequences)
----- --- ---
-15 21 0|==
-14 117 0|=========
-13 252 3|*===================
-12 396 99|=======*=======================
-11 618 516|=======================================*========
-10 713 958|======================================================= *
-9 728 989|======================================================== *
-8 563 740|============================================ *
-7 387 467|============================== *
-6 219 268|================= *
-5 134 147|===========*
-4 69 78|=====*
-3 53 41|===*=
-2 23 21|=*
-1 19 11|*=
0 11 5|*
1 2 3|*
2 1 1|*
3 2 0|=
4 0 0|
> 5 30 -|===


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 1114.4050
P(chi-square) = 0

Total sequences searched: 4358

Whole sequence top hits:
tophits_s report:
Total hits: 22
Satisfying E cutoff: 22
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 23
Satisfying E cutoff: 23
Total memory: 30K


Acknowledgements:

This research is funded by:

Developed by: