Acidobacteria Actinobacteria Alphaproteobacteria
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Chlamydiae/Verrucomicrobia Chloroflexi Cyanobacteria
Deinococcus-Thermus Deltaproteobacteria Epsilonproteobacteria
Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
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264 projects found  

1 accessions found for Shigella flexneri 2a str. 2457T  

Data for AE014073  

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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: AE014073.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
AE014073_2565 CDS_2868747-2871503 100.1 4.9e-28 1
AE014073_0325 CDS_346531-347826 91.0 2e-25 1
AE014073_2211 CDS_2465576-2469169 81.6 8.7e-23 1
AE014073_2091 CDS_2320736-2317887 80.6 1.7e-22 1
AE014073_2981 CDS_3336309-3333973 78.9 5.2e-22 1
AE014073_2377 CDS_2669619-2668129 73.0 2.4e-20 1
AE014073_1953 CDS_2152520-2153923 69.8 2e-19 1
AE014073_3228 CDS_3653260-3654633 66.6 1.6e-18 1
AE014073_4069 CDS_4594399-4595823 62.4 2.4e-17 1
AE014073_3149 CDS_3552312-3550936 61.5 4.4e-17 1
AE014073_0449 CDS_488477-487035 61.0 6.1e-17 1
AE014073_2810 CDS_3152358-3153632 60.7 7.6e-17 1
AE014073_3276 CDS_3704192-3705241 59.7 1.5e-16 1
AE014073_3747 CDS_4267522-4268874 55.0 3e-15 1
AE014073_1836 CDS_2016943-2015585 51.1 3.8e-14 1
AE014073_3115 CDS_3496895-3495795 45.0 2.1e-12 1
AE014073_1554 CDS_1698900-1700201 42.4 1.2e-11 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
AE014073_2565 1/1 292 357 .. 1 87 [] 100.1 4.9e-28
AE014073_0325 1/1 203 269 .. 1 87 [] 91.0 2e-25
AE014073_2211 1/1 711 777 .. 1 87 [] 81.6 8.7e-23
AE014073_2091 1/1 469 534 .. 1 87 [] 80.6 1.7e-22
AE014073_2981 1/1 282 347 .. 1 87 [] 78.9 5.2e-22
AE014073_2377 1/1 270 338 .. 1 87 [] 73.0 2.4e-20
AE014073_1953 1/1 240 304 .. 1 87 [] 69.8 2e-19
AE014073_3228 1/1 238 300 .. 1 87 [] 66.6 1.6e-18
AE014073_4069 1/1 255 320 .. 1 87 [] 62.4 2.4e-17
AE014073_3149 1/1 237 303 .. 1 87 [] 61.5 4.4e-17
AE014073_0449 1/1 261 327 .. 1 87 [] 61.0 6.1e-17
AE014073_2810 1/1 236 302 .. 1 87 [] 60.7 7.6e-17
AE014073_3276 1/1 129 186 .. 1 79 [. 59.7 1.5e-16
AE014073_3747 1/1 233 293 .. 1 87 [] 55.0 3e-15
AE014073_1836 1/1 235 301 .. 1 87 [] 51.1 3.8e-14
AE014073_3115 1/1 145 205 .. 1 87 [] 45.0 2.1e-12
AE014073_1554 1/1 211 271 .. 1 87 [] 42.4 1.2e-11

Alignments of top-scoring domains:
AE014073_2565: domain 1 of 1, from 292 to 357: score 100.1, E = 4.9e-28
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g++ l l+ tel++ q
AE014073_2 292 IKSEFLANMSHELRTPLNGVIGFTRLTLK---------TELTPTQ-- 327

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ti+r+a+ ll++ind+Ld+s++eag
AE014073_2 328 ----------RDHLNTIERSANNLLAIINDVLDFSKLEAG 357

AE014073_0325: domain 1 of 1, from 203 to 269: score 91.0, E = 2e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ f+an+sHELRTPLt+++gy+e++ e ++l r
AE014073_0 203 ARRNFFANVSHELRTPLTVLQGYLEMMDE---------QPLEGAVR- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l+t++++++r++ L+ +lL+ls+iea
AE014073_0 240 ----------EKALHTMREQTQRMEGLVKQLLTLSKIEAA 269

AE014073_2211: domain 1 of 1, from 711 to 777: score 81.6, E = 8.7e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla++sHE+RTP+++I+g++elL + ls eqr
AE014073_2 711 AKSQFLATMSHEIRTPISSIMGFLELLSG---------SGLSKEQR- 747

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ ++ +++ll Li ++Ld +ie+g
AE014073_2 748 ----------VEAISLAYATGQSLLGLIGEILDVDKIESG 777

AE014073_2091: domain 1 of 1, from 469 to 534: score 80.6, E = 1.7e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks fla++sHELRTPL +I+g+++lL++ el+
AE014073_2 469 SKSMFLATVSHELRTPLYGIIGNLDLLQT---------KELPKGV-- 504

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + +++ ll++i+d+Ld+s+ie++
AE014073_2 505 ----------DRLVTAMNNSSSLLLKIISDILDFSKIESE 534

AE014073_2981: domain 1 of 1, from 282 to 347: score 78.9, E = 5.2e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+ f++++sHELRTPL++I g++ +Ll+ tel++eq
AE014073_2 282 DKTTFISTISHELRTPLNGIVGLSRILLD---------TELTAEQ-- 317

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+ti+ +a l ++ nd+ d+ ++e
AE014073_2 318 ----------EKYLKTIHVSAVTLGNIFNDIIDMDKMERR 347

AE014073_2377: domain 1 of 1, from 270 to 338: score 73.0, E = 2.4e-20
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +fl++lsHEL+TPL+++r +elL +++ ++l++eq
AE014073_2 270 QRHQFLRHLSHELKTPLASMREGTELLADQV------VGPLTPEQ-- 308

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e ++++++++ l++Li++lLd+ r +a
AE014073_2 309 ----------KEVVSILDSSSCNLQKLIEQLLDYNRKQAD 338

AE014073_1953: domain 1 of 1, from 240 to 304: score 69.8, E = 2e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+a++sHELRTPL+++rg +e++++++ + ++e+
AE014073_1 240 MRRDFMADISHELRTPLAVLRGELEAIQDGV-------RKFTPET-- 277

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +++ e+ l +L++dl +ls ++g
AE014073_1 278 -------------VASLQAEVGTLTKLVDDLHQLSMSDEG 304

AE014073_3228: domain 1 of 1, from 238 to 300: score 66.6, E = 1.6e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++++l+++sHELRTPLt +++ + lL++ +++
AE014073_3 238 SQQRLLSDISHELRTPLTRLQLGTALLRR---------RSGESKE-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i+ ea+rl+++indlL +sr ++
AE014073_3 274 -------------LERIETEAQRLDSMINDLLVMSRNQQK 300

AE014073_4069: domain 1 of 1, from 255 to 320: score 62.4, E = 2.4e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + +l HEL+ PL+aIrg+ae+L+e ++ +e
AE014073_4 255 YIEQYVYALTHELKSPLAAIRGAAEILRE---------GPPPEVV-- 290

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++++ il + r+++L++ lL +r+e+
AE014073_4 291 ----------ARFTDNILTQNARMQALVETLLRQARLENR 320

AE014073_3149: domain 1 of 1, from 237 to 303: score 61.5, E = 4.4e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++a+++HE+R+PL++I+g+a+ e +++++ e
AE014073_3 237 ALGHLAAGVAHEIRNPLSSIKGLAKYFAE--------RAPAGGEA-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ +++ +ea+rl+r +++lL+l + +
AE014073_3 274 ----------HQLAQVMAKEADRLNRVVSELLELVKPTHL 303

AE014073_0449: domain 1 of 1, from 261 to 327: score 61.0, E = 6.1e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s f a+++HE+RTP+t +++ +e++l + +s +++
AE014073_0 261 RQSNFSADIAHEIRTPITNLITQTEIALS---------QSRSQKEL- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e+ r+ ++++d+L l++++++
AE014073_0 298 ----------EDVLYSNLEELTRMAKMVSDMLFLAQADNN 327

AE014073_2810: domain 1 of 1, from 236 to 302: score 60.7, E = 7.6e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++f+++++HELR PLta++ +e+++ ++ +++ r
AE014073_2 236 RERRFTSDAAHELRSPLTALKVQTEVAQL---------SDDDPQAR- 272

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++ ++r rL+++lL+lsr+++
AE014073_2 273 ----------KKALLQLHSGIDRATRLVDQLLTLSRLDSL 302

AE014073_3276: domain 1 of 1, from 129 to 186: score 59.7, E = 1.5e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++++l+HE+++PL ++rg+a+lL + +l+++ +
AE014073_3 129 AARDLVRGLAHEIKNPLGGLRGAAQLLSK----------ALPDPSL- 164

peLRledpeyreyletilreaerllrLindlL<-*
ey+++i+++a+rl++L+++lL
AE014073_3 165 ----------LEYTKVIIEQADRLRNLVDRLL 186

AE014073_3747: domain 1 of 1, from 233 to 293: score 55.0, E = 3e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ ++a++sH+LRTPLt Ir+++e++ e ++
AE014073_3 233 DRTLLMAGVSHDLRTPLTRIRLATEMMSE---------QD------- 263

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e+i +++e ++++i+++ d+ r +++
AE014073_3 264 ----------GYLAESINKDIEECNAIIEQFIDYLRTGQE 293

AE014073_1836: domain 1 of 1, from 235 to 301: score 51.1, E = 3.8e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s+f+ +l+HELRTP++a++g ++ l + +s +
AE014073_1 235 RLSQFADDLAHELRTPINALLGQNQVTLS---------QIRSIAE-- 270

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y++ + ++e+e ++rL +++L l+r++ +
AE014073_1 271 ---------YQKTIAGNIEELENISRLTENILFLARADKN 301

AE014073_3115: domain 1 of 1, from 145 to 205: score 45.0, E = 2.1e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+++r+++elL + t+
AE014073_3 145 NERLFTADVAHELRTPLAGVRLHLELLAK---------TH------- 175

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + ++++ + +++lL+l+r+++
AE014073_3 176 ----------HIDVAPLVARLDQMMESVSQLLQLARAGQS 205

AE014073_1554: domain 1 of 1, from 211 to 271: score 42.4, E = 1.2e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k +++ +++HELRTPL +r +e+ + ls+ +
AE014073_1 211 SKKQLIDGIAHELRTPLVRLRYRLEMSDN-----------LSAAE-- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + r++ +l++Li++lL+++r++ +
AE014073_1 245 -------------SQALNRDISQLEALIEELLTYARLDRP 271


Histogram of all scores:
score obs exp (one = represents 13 sequences)
----- --- ---
-16 1 0|=
-15 2 0|=
-14 14 0|==
-13 42 3|*===
-12 165 92|=======*=====
-11 500 482|=====================================*=
-10 685 894|===================================================== *
-9 760 923|==========================================================*
-8 669 691|==================================================== *
-7 459 435|=================================*==
-6 275 250|===================*==
-5 250 137|==========*=========
-4 94 73|=====*==
-3 41 38|==*=
-2 37 20|=*=
-1 25 10|*=
0 14 5|*=
1 7 2|*
2 6 1|*
3 3 0|=
4 0 0|
> 5 19 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 281.8918
P(chi-square) = 0

Total sequences searched: 4073

Whole sequence top hits:
tophits_s report:
Total hits: 17
Satisfying E cutoff: 17
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 17
Satisfying E cutoff: 17
Total memory: 27K


Acknowledgements:

This research is funded by:

Developed by: