Acidobacteria Actinobacteria Alphaproteobacteria
Aquificae Bacteroidetes/Chlorobi Betaproteobacteria
Chlamydiae/Verrucomicrobia Chloroflexi Cyanobacteria
Deinococcus-Thermus Deltaproteobacteria Epsilonproteobacteria
Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
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264 projects found  

1 accessions found for Escherichia coli 536  

Data for CP000247  

Available Atlases
Other Plots
hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000247.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000247_2742 CDS_2908466-2911222 100.1 5.7e-28 1
CP000247_0452 CDS_485380-486675 91.0 2.3e-25 1
CP000247_2374 CDS_2507809-2511402 81.6 1e-22 1
CP000247_0976 CDS_1050503-1047771 80.7 1.8e-22 1
CP000247_2241 CDS_2356924-2354075 80.6 2e-22 1
CP000247_3268 CDS_3463332-3460996 78.9 6e-22 1
CP000247_2242 CDS_2357091-2358917 77.9 1.1e-21 1
CP000247_2533 CDS_2696558-2695068 75.4 5.9e-21 1
CP000247_2099 CDS_2199995-2201398 70.4 1.5e-19 1
CP000247_4081 CDS_4304344-4302971 66.6 1.8e-18 1
CP000247_4681 CDS_4933964-4935388 62.4 2.7e-17 1
CP000247_0593 CDS_632289-630847 61.0 7e-17 1
CP000247_3084 CDS_3278884-3280233 60.7 8.7e-17 1
CP000247_4171 CDS_4412837-4414213 60.1 1.2e-16 1
CP000247_4040 CDS_4262038-4260989 59.7 1.7e-16 1
CP000247_3460 CDS_3642194-3640842 55.0 3.5e-15 1
CP000247_1884 CDS_1942946-1941588 52.3 2e-14 1
CP000247_4309 CDS_4565374-4564283 45.0 2.4e-12 1
CP000247_1538 CDS_1602314-1603615 42.4 1.3e-11 1
CP000247_2947 CDS_3144140-3142131 29.4 6.4e-08 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000247_2742 1/1 292 357 .. 1 87 [] 100.1 5.7e-28
CP000247_0452 1/1 203 269 .. 1 87 [] 91.0 2.3e-25
CP000247_2374 1/1 711 777 .. 1 87 [] 81.6 1e-22
CP000247_0976 1/1 443 508 .. 1 87 [] 80.7 1.8e-22
CP000247_2241 1/1 469 534 .. 1 87 [] 80.6 2e-22
CP000247_3268 1/1 282 347 .. 1 87 [] 78.9 6e-22
CP000247_2242 1/1 388 453 .. 1 87 [] 77.9 1.1e-21
CP000247_2533 1/1 270 338 .. 1 87 [] 75.4 5.9e-21
CP000247_2099 1/1 240 304 .. 1 87 [] 70.4 1.5e-19
CP000247_4081 1/1 238 300 .. 1 87 [] 66.6 1.8e-18
CP000247_4681 1/1 255 320 .. 1 87 [] 62.4 2.7e-17
CP000247_0593 1/1 261 327 .. 1 87 [] 61.0 7e-17
CP000247_3084 1/1 236 302 .. 1 87 [] 60.7 8.7e-17
CP000247_4171 1/1 237 303 .. 1 87 [] 60.1 1.2e-16
CP000247_4040 1/1 129 186 .. 1 79 [. 59.7 1.7e-16
CP000247_3460 1/1 233 293 .. 1 87 [] 55.0 3.5e-15
CP000247_1884 1/1 235 301 .. 1 87 [] 52.3 2e-14
CP000247_4309 1/1 142 202 .. 1 87 [] 45.0 2.4e-12
CP000247_1538 1/1 211 271 .. 1 87 [] 42.4 1.3e-11
CP000247_2947 1/1 448 516 .. 1 87 [] 29.4 6.4e-08

Alignments of top-scoring domains:
CP000247_2742: domain 1 of 1, from 292 to 357: score 100.1, E = 5.7e-28
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g++ l l+ tel++ q
CP000247_2 292 IKSEFLANMSHELRTPLNGVIGFTRLTLK---------TELTPTQ-- 327

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ti+r+a+ ll++ind+Ld+s++eag
CP000247_2 328 ----------RDHLNTIERSANNLLAIINDVLDFSKLEAG 357

CP000247_0452: domain 1 of 1, from 203 to 269: score 91.0, E = 2.3e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ f+an+sHELRTPLt+++gy+e++ e ++l r
CP000247_0 203 ARRNFFANVSHELRTPLTVLQGYLEMMDE---------QPLEGAVR- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l+t++++++r++ L+ +lL+ls+iea
CP000247_0 240 ----------EKALHTMREQTQRMEGLVKQLLTLSKIEAA 269

CP000247_2374: domain 1 of 1, from 711 to 777: score 81.6, E = 1e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla++sHE+RTP+++I+g++elL + ls eqr
CP000247_2 711 AKSQFLATMSHEIRTPISSIMGFLELLSG---------SGLSKEQR- 747

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ ++ +++ll Li ++Ld +ie+g
CP000247_2 748 ----------VEAISLAYATGQSLLGLIGEILDVDKIESG 777

CP000247_0976: domain 1 of 1, from 443 to 508: score 80.7, E = 1.8e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks fla++sHE+RTPL +I+g+a+lL + ++ q
CP000247_0 443 AKSAFLAAMSHEIRTPLYGILGTAQLLAD---------NPALNAQ-- 478

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ i +++e+ll ++nd+Ld+s ieag
CP000247_0 479 ----------RDDLRAITDSGESLLTILNDILDYSAIEAG 508

CP000247_2241: domain 1 of 1, from 469 to 534: score 80.6, E = 2e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks fla++sHELRTPL +I+g+++lL++ el+
CP000247_2 469 SKSMFLATVSHELRTPLYGIIGNLDLLQT---------KELPKGV-- 504

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + +++ ll++i+d+Ld+s+ie++
CP000247_2 505 ----------DRLVTAMNNSSSLLLKIISDILDFSKIESE 534

CP000247_3268: domain 1 of 1, from 282 to 347: score 78.9, E = 6e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+ f++++sHELRTPL++I g++ +Ll+ tel++eq
CP000247_3 282 DKTTFISTISHELRTPLNGIVGLSRILLD---------TELTAEQ-- 317

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+ti+ +a l ++ nd+ d+ ++e
CP000247_3 318 ----------EKYLKTIHVSAVTLGNIFNDIIDMDKMERR 347

CP000247_2242: domain 1 of 1, from 388 to 453: score 77.9, E = 1.1e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++e++a+++HE R+PLtaIrgy+++L+ +++++ +
CP000247_2 388 TLGELMAGVAHEVRNPLTAIRGYVQILRQ---------QTRDPIH-- 423

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+eyl+++l+e++++++ i++lL++sr ++
CP000247_2 424 ----------QEYLSVVLKEIDSINKVIQQLLEFSRPRHS 453

CP000247_2533: domain 1 of 1, from 270 to 338: score 75.4, E = 5.9e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +fl++lsHEL+TPL+++r +elL +++ ++l++eq
CP000247_2 270 QRHQFLRHLSHELKTPLASMREGTELLADQV------VGPLTPEQ-- 308

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e +++++++++ l++Li++lLd+ r +a
CP000247_2 309 ----------KEVVSILDSSSRNLQKLIEQLLDYNRKQAD 338

CP000247_2099: domain 1 of 1, from 240 to 304: score 70.4, E = 1.5e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+a++sHELRTPL+++rg +e++++++ + ++e+
CP000247_2 240 MRRDFMADISHELRTPLAVLRGELEAIQDGV-------RKFTPET-- 277

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
l +++ e+ l +L++dl +ls ++g
CP000247_2 278 -------------LASLQAEVGTLTKLVDDLHQLSMSDEG 304

CP000247_4081: domain 1 of 1, from 238 to 300: score 66.6, E = 1.8e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++++l+++sHELRTPLt +++ + lL++ +++
CP000247_4 238 SQQRLLSDISHELRTPLTRLQLGTALLRR---------RSGESKE-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i+ ea+rl+++indlL +sr ++
CP000247_4 274 -------------LERIETEAQRLDSMINDLLVMSRNQQK 300

CP000247_4681: domain 1 of 1, from 255 to 320: score 62.4, E = 2.7e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + +l HEL+ PL+aIrg+ae+L+e ++ +e
CP000247_4 255 YIEQYVYALTHELKSPLAAIRGAAEILRE---------GPPPEVV-- 290

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++++ il + r+++L++ lL +r+e+
CP000247_4 291 ----------ARFTDNILTQNARMQALVETLLRQARLENR 320

CP000247_0593: domain 1 of 1, from 261 to 327: score 61.0, E = 7e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s f a+++HE+RTP+t +++ +e++l + +s +++
CP000247_0 261 RQSNFSADIAHEIRTPITNLITQTEIALS---------QSRSQKEL- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e+ r+ ++++d+L l++++++
CP000247_0 298 ----------EDVLYSNLEELTRMAKMVSDMLFLAQADNN 327

CP000247_3084: domain 1 of 1, from 236 to 302: score 60.7, E = 8.7e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++f+++++HELR PLta++ +e+++ ++ +++ r
CP000247_3 236 RERRFTSDAAHELRSPLTALKVQTEVAQL---------SDDDPQAR- 272

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++ ++r rL+++lL+lsr+++
CP000247_3 273 ----------KKALLQLHSGIDRATRLVDQLLTLSRLDSL 302

CP000247_4171: domain 1 of 1, from 237 to 303: score 60.1, E = 1.2e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++a+++HE+R+PL++I+g+a+ e ++ ++ e
CP000247_4 237 ALGHLAAGVAHEIRNPLSSIKGLAKYFAE--------RASAGGEA-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ +++ +ea+rl+r +++lL+l + +
CP000247_4 274 ----------HQLAQVMAKEADRLNRVVSELLELVKPTHL 303

CP000247_4040: domain 1 of 1, from 129 to 186: score 59.7, E = 1.7e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++++l+HE+++PL ++rg+a+lL + +l+++ +
CP000247_4 129 AARDLVRGLAHEIKNPLGGLRGAAQLLSK----------ALPDPSL- 164

peLRledpeyreyletilreaerllrLindlL<-*
ey+++i+++a+rl++L+++lL
CP000247_4 165 ----------LEYTKVIIEQADRLRNLVDRLL 186

CP000247_3460: domain 1 of 1, from 233 to 293: score 55.0, E = 3.5e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ ++a++sH+LRTPLt Ir+++e++ e ++
CP000247_3 233 DRTLLMAGVSHDLRTPLTRIRLATEMMSE---------QD------- 263

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e+i +++e ++++i+++ d+ r +++
CP000247_3 264 ----------GYLAESINKDIEECNAIIEQFIDYLRTGQE 293

CP000247_1884: domain 1 of 1, from 235 to 301: score 52.3, E = 2e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s+f+ +l+HELRTP++a++g ++ l +++s +
CP000247_1 235 RLSQFADDLAHELRTPINALLGQNQVTLS---------QTRSIAE-- 270

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y++ + ++e+e ++rL +++L l+r++ +
CP000247_1 271 ---------YQKTIAGNIEELENISRLTENILFLARADKN 301

CP000247_4309: domain 1 of 1, from 142 to 202: score 45.0, E = 2.4e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+++r+++elL + t+
CP000247_4 142 NERLFTADVAHELRTPLAGVRLHLELLAK---------TH------- 172

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + ++++ + +++lL+l+r+++
CP000247_4 173 ----------HIDVAPLVARLDQMMESVSQLLQLARAGQS 202

CP000247_1538: domain 1 of 1, from 211 to 271: score 42.4, E = 1.3e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k +++ +++HELRTPL +r +e+ + ls+ +
CP000247_1 211 SKKQLIDGIAHELRTPLVRLRYRLEMSDN-----------LSAAE-- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + r++ +l++Li++lL+++r++ +
CP000247_1 245 -------------SQALNRDISQLEALIEELLTYARLDRP 271

CP000247_2947: domain 1 of 1, from 448 to 516: score 29.4, E = 6.4e-08
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + +l+HE+++PL+a+++y+ ++++ a+++++ e+
CP000247_2 448 VVGQTMTTLAHEINQPLNALSMYLFTARR------AIEQTQKEQA-- 486

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+l +++ + r++++i+ l++++r +
CP000247_2 487 ----------SMMLGKAEGVISRIDAIIRSLRQFTRRAEL 516


Histogram of all scores:
score obs exp (one = represents 15 sequences)
----- --- ---
-15 4 0|=
-14 24 0|==
-13 79 3|*=====
-12 259 105|======*===========
-11 475 548|================================ *
-10 810 1017|====================================================== *
-9 834 1051|======================================================== *
-8 771 787|====================================================*
-7 561 496|=================================*====
-6 340 285|==================*====
-5 201 156|==========*===
-4 98 83|=====*=
-3 54 44|==*=
-2 30 23|=*
-1 33 12|*==
0 16 6|*=
1 7 3|*
2 7 1|*
3 2 0|=
4 0 0|
> 5 24 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 408.0702
P(chi-square) = 0

Total sequences searched: 4685

Whole sequence top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 28K


Acknowledgements:

This research is funded by:

Developed by: