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Firmicutes Fusobacteria Gammaproteobacteria
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Thermotogae
Classification of phyla is from NCBI page
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4 accessions found for   

Data for CP000390  

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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000390.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000390_0897 CDS_1000551-998227 100.1 5.1e-28 1
CP000390_1544 CDS_1672207-1670690 95.5 1e-26 1
CP000390_3643 CDS_3966491-3968725 95.3 1.2e-26 1
CP000390_0171 CDS_214333-210755 89.5 5e-25 1
CP000390_1930 CDS_2079511-2082627 88.0 1.4e-24 1
CP000390_0872 CDS_969421-971067 83.6 2.3e-23 1
CP000390_0012 CDS_12513-11239 79.3 3.8e-22 1
CP000390_3541 CDS_3849634-3852165 70.0 1.7e-19 1
CP000390_0339 CDS_378872-381322 63.3 1.3e-17 1
CP000390_3536 CDS_3844581-3846350 60.5 8.6e-17 1
CP000390_0895 CDS_993661-995067 56.3 1.3e-15 1
CP000390_1609 CDS_1746159-1745026 53.2 1e-14 1
CP000390_0090 CDS_118637-122128 45.1 2e-12 1
CP000390_4004 CDS_4350386-4349061 43.1 7.2e-12 1
CP000390_1607 CDS_1743470-1741179 42.0 1.4e-11 1
CP000390_1892 CDS_2039488-2041443 40.8 3.1e-11 1
CP000390_1729 CDS_1861378-1858778 40.5 3.9e-11 1
CP000390_2132 CDS_2297318-2298727 37.8 2.3e-10 1
CP000390_2210 CDS_2372725-2371352 37.7 2.4e-10 1
CP000390_4038 CDS_4386592-4385342 37.4 2.9e-10 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000390_0897 1/1 542 611 .. 1 87 [] 100.1 5.1e-28
CP000390_1544 1/1 259 328 .. 1 87 [] 95.5 1e-26
CP000390_3643 1/1 237 302 .. 1 87 [] 95.3 1.2e-26
CP000390_0171 1/1 960 1029 .. 1 87 [] 89.5 5e-25
CP000390_1930 1/1 364 432 .. 1 87 [] 88.0 1.4e-24
CP000390_0872 1/1 290 359 .. 1 87 [] 83.6 2.3e-23
CP000390_0012 1/1 195 262 .. 1 87 [] 79.3 3.8e-22
CP000390_3541 1/1 611 679 .. 1 87 [] 70.0 1.7e-19
CP000390_0339 1/1 449 514 .. 1 87 [] 63.3 1.3e-17
CP000390_3536 1/1 355 420 .. 1 87 [] 60.5 8.6e-17
CP000390_0895 1/1 243 309 .. 1 87 [] 56.3 1.3e-15
CP000390_1609 1/1 133 197 .. 1 87 [] 53.2 1e-14
CP000390_0090 1/1 799 864 .. 1 87 [] 45.1 2e-12
CP000390_4004 1/1 209 275 .. 1 87 [] 43.1 7.2e-12
CP000390_1607 1/1 511 582 .. 1 87 [] 42.0 1.4e-11
CP000390_1892 1/1 281 348 .. 1 87 [] 40.8 3.1e-11
CP000390_1729 1/1 477 543 .. 1 87 [] 40.5 3.9e-11
CP000390_2132 1/1 266 324 .. 1 87 [] 37.8 2.3e-10
CP000390_2210 1/1 227 298 .. 1 87 [] 37.7 2.4e-10
CP000390_4038 1/1 48 114 .. 1 87 [] 37.4 2.9e-10

Alignments of top-scoring domains:
CP000390_0897: domain 1 of 1, from 542 to 611: score 100.1, E = 5.1e-28
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
akseflan+sHELRTPL+aI+g++el++ +l+ ++l++e
CP000390_0 542 AKSEFLANMSHELRTPLNAIIGFSELMQQGLF------GPLGSER-- 580

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y+ey++ i++++ +ll ind+Ld+s+ieag
CP000390_0 581 ---------YQEYVNDIYSSGTYLLGVINDILDMSKIEAG 611

CP000390_1544: domain 1 of 1, from 259 to 328: score 95.5, E = 1e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla++sHELRTPL+aI+g++e++ + + l++ q+
CP000390_1 259 AKSRFLASMSHELRTPLNAILGFSEVMAK---------EVLGPVQNV 296

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ rey + +++++++ll+Lin++Ldlsrieag
CP000390_1 297 TY--------REYAKDVHQSGQHLLELINEILDLSRIEAG 328

CP000390_3643: domain 1 of 1, from 237 to 302: score 95.3, E = 1.2e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla++sHE+RTP+++I+g+a lL + t ls+eq
CP000390_3 237 AKSRFLATVSHEIRTPMNGIIGMATLLSD---------TRLSSEQ-- 272

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r y+ i +a ll+Li+dlLd+s+ieag
CP000390_3 273 ----------RTYVAAISTSASALLALIEDLLDYSKIEAG 302

CP000390_0171: domain 1 of 1, from 960 to 1029: score 89.5, E = 5e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ksefla +sHE+RTPL+aI+g++el+ + + ++ + +
CP000390_0 960 QKSEFLARVSHEIRTPLNAIIGFSELMID------EKFGPIGNDR-- 998

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
yr+yl+ i r++++ l+L+ndlLd+s+ieag
CP000390_0 999 ---------YRDYLRDINRSGNHVLDLVNDLLDISKIEAG 1029

CP000390_1930: domain 1 of 1, from 364 to 432: score 88.0, E = 1.4e-24
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++ +a lL + ++++l+++q
CP000390_1 364 YKSEFLANMSHELRTPLNSLLIMARLLAD------NREGNLTSDQ-- 402

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ eti+ +++ ll+Lind+Ld+s+ieag
CP000390_1 403 ----------VKFAETIETAGNDLLNLINDILDISKIEAG 432

CP000390_0872: domain 1 of 1, from 290 to 359: score 83.6, E = 2.3e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++e+la++sHELRTPL+aI g+a+lL +e++ ++ +++
CP000390_0 290 SRDEMLASVSHELRTPLNAIVGFADLLANEMF------GKFANDKQ- 329

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
rey+e+i++++ +ll+ +n +Ld s+ ++g
CP000390_0 330 ----------REYVEVIREAGTHLLSVVNAILDVSKVQSG 359

CP000390_0012: domain 1 of 1, from 195 to 262: score 79.3, E = 3.8e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +f+an+sHELRTPL++I g++e+L+ +++++ +++
CP000390_0 195 MRADFIANASHELRTPLASIAGFIETLRG---------PARDDAKAR 232

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+l+++++++ r+ rLi+dlL lsr+e
CP000390_0 233 ----------DSFLQIMQDQTSRMARLIDDLLSLSRLEVK 262

CP000390_3541: domain 1 of 1, from 611 to 679: score 70.0, E = 1.7e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k++f+ ++s ELR PLt I+g++elL e ++l++ q
CP000390_3 611 LKNDFVQHVSYELRSPLTNIIGFTELLGQETT------GPLNPRQ-- 649

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
rey++ i +++ ll ++nd+Ldl+ +ag
CP000390_3 650 ----------REYVDHIGSSSSLLLTIVNDILDLATVDAG 679

CP000390_0339: domain 1 of 1, from 449 to 514: score 63.3, E = 1.3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ks+fla++sH+LR+PL+a+ +++ L++ e+++ +r
CP000390_0 449 FKSRFLAAASHDLRQPLHALNLFIAQLRN----------EADPVER- 484

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++ +i+ ++ + ++L++ lLd+s++eag
CP000390_0 485 ----------ARLVGRIDVAVGSVNELLEALLDMSKLEAG 514

CP000390_3536: domain 1 of 1, from 355 to 420: score 60.5, E = 8.6e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + f+a+++HEL++PLt++ ++e+L +++e r
CP000390_3 355 AIESFAADVAHELKNPLTSLGSAVETLPL----------AKDERSR- 390

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ e+i+++++rl+rLi d+ d sr++a+
CP000390_3 391 ----------ERLMEIIQHDVRRLDRLITDISDASRLDAE 420

CP000390_0895: domain 1 of 1, from 243 to 309: score 56.3, E = 1.3e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ + an++H+L+TPLt +r ae++l+ + +++ +
CP000390_0 243 GLKQVSANIAHDLKTPLTRLRNRAEAALN---------SSGGPDAA- 279

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e+le + e+++l r n +L +sr+eag
CP000390_0 280 ----------KEALEQTIAESDQLIRTFNAILMISRLEAG 309

CP000390_1609: domain 1 of 1, from 133 to 197: score 53.2, E = 1e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ + ++a+l+HE+++PL++Irg+a+lL+ s+e+
CP000390_1 133 SVTGLAAMLAHEIKNPLSGIRGAAQLLEH----------VVSDED-- 167

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r + + i +e++r+ +L++++ ++s +
CP000390_1 168 ----------RALARLITEETDRIVALVDRMEEFSDERPV 197

CP000390_0090: domain 1 of 1, from 799 to 864: score 45.1, E = 2e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k++fla++ H++ +PL+a r+y+ L+e + + +++
CP000390_0 799 GKTRFLAAAGHDILQPLNAARLYCTPLKE----------KTDRQDL- 834

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ ++e+i++++++ + ++ +Ld+sr+++g
CP000390_0 835 ----------HAFVESIESSLDSVETILGAVLDISRLDTG 864

CP000390_4004: domain 1 of 1, from 209 to 275: score 43.1, E = 7.2e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++a+++HEL TPL++I + a +++ +l++++r
CP000390_4 209 ALDGLAAAAAHELGTPLATIALVAREMEK----------ALGDDTR- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+re + +++++er+++++ +l ls ++
CP000390_4 245 ---------FREDVTLLRSQSERCRQILKRLTSLSSEGEA 275

CP000390_1607: domain 1 of 1, from 511 to 582: score 42.0, E = 1.4e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + ++ ++HE+++PLt I++ ae +++++ +e+ ++
CP000390_1 511 AWADVARRIAHEIKNPLTPIQLSAERIRRRFG------KVITEDRAI 551

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + ++ti+r++ + r+++++ ++r+ +
CP000390_1 552 ---------FDQCTDTIIRQVGDIGRMVDEFSAFARMPKP 582

CP000390_1892: domain 1 of 1, from 281 to 348: score 40.8, E = 3.1e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++ +++H++++ L +I+ ++lL+++l + ++e +
CP000390_1 281 AIGQLTGGVAHDFNNLLMVILSSLDLLRRKL--------PDNDERI- 318

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r +++ + ++a+r +L +++L ++r ++
CP000390_1 319 ----------RSLVDNAVQAAQRGASLTQRMLSFARRQEL 348

CP000390_1729: domain 1 of 1, from 477 to 543: score 40.5, E = 3.9e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++ +++H++++ LtaI+++++lLl+ +++++
CP000390_1 477 AVGQLAGGIAHDFNNVLTAIIMASDLLLT---------NHRPSDPS- 513

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ i++ a+r +L+++lL +sr ++
CP000390_1 514 ----------FPDIMNIKQNANRAASLVRQLLAFSRRQTL 543

CP000390_2132: domain 1 of 1, from 266 to 324: score 37.8, E = 2.3e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++ +l ++sH+LRT Lt ++ + l+++
CP000390_2 266 QRTAMLTGVSHDLRTILTRFKLQLALARN------------------ 294

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r ++ +++++e ++ +++ L ++r ea+
CP000390_2 295 ----------RTDIKALDQDVEEMRLMLEGYLAFARGEAQ 324

CP000390_2210: domain 1 of 1, from 227 to 298: score 37.7, E = 2.4e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkv.lagdtelseeqr
+++e++++l+HEL++PL+aI y++ + + + d++l +
CP000390_2 227 ELGEMASTLAHELNQPLSAIANYVQGCSR----LlKNMDDALASRM- 268

lpeLRledpeyreyletilreaerllrLindlLdlsrieag<-*
re+l+ r++ r ++i+ l+++ ++
CP000390_2 269 -----------REALDETARQTLRAGQIIRHLREFVTRGET 298

CP000390_4038: domain 1 of 1, from 48 to 114: score 37.4, E = 2.9e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++ +++H++++ L++I+ ++ l+++ + e+
CP000390_4 48 AVGQLTGGIAHDFNNMLAVIISALNLIER---------RVAQGED-- 83

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++e++e +++ a r +L ++lL +sr +a
CP000390_4 84 ---------FAEFIEAAKDGAARAASLTQRLLAFSRQQAL 114


Histogram of all scores:
score obs exp (one = represents 15 sequences)
----- --- ---
-14 7 0|=
-13 29 3|*=
-12 142 92|======*===
-11 347 481|======================== *
-10 701 893|=============================================== *
-9 828 922|======================================================== *
-8 703 690|=============================================*=
-7 523 435|============================*======
-6 358 250|================*=======
-5 192 137|=========*===
-4 90 73|====*=
-3 49 38|==*=
-2 31 20|=*=
-1 13 10|*
0 15 5|*
1 4 2|*
2 6 1|*
3 0 0|
4 3 0|=
5 0 0|
> 6 23 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 228.7637
P(chi-square) = 6.817e-312

Total sequences searched: 4064

Whole sequence top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 28K


Acknowledgements:

This research is funded by:

Developed by: