Acidobacteria Actinobacteria Alphaproteobacteria
Aquificae Bacteroidetes/Chlorobi Betaproteobacteria
Chlamydiae/Verrucomicrobia Chloroflexi Cyanobacteria
Deinococcus-Thermus Deltaproteobacteria Epsilonproteobacteria
Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
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Data for CP000447  

Available Atlases
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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000447.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000447_3468 CDS_4170877-4167167 96.0 7.2e-27 1
CP000447_2485 CDS_2996780-3000178 93.0 5.3e-26 1
CP000447_1037 CDS_1233334-1230476 92.4 7.5e-26 1
CP000447_1009 CDS_1194719-1197328 84.1 1.7e-23 1
CP000447_2790 CDS_3390672-3385774 82.1 6.3e-23 1
CP000447_3095 CDS_3733397-3731139 77.2 1.6e-21 1
CP000447_2745 CDS_3328363-3327068 77.0 1.8e-21 1
CP000447_1975 CDS_2360439-2363438 75.5 4.6e-21 1
CP000447_3969 CDS_4777646-4775298 74.2 1.1e-20 1
CP000447_0321 CDS_351725-350688 61.8 3.6e-17 1
CP000447_3640 CDS_4358594-4357338 59.8 1.3e-16 1
CP000447_1119 CDS_1328158-1329561 57.0 8e-16 1
CP000447_1169 CDS_1388861-1389931 54.7 3.6e-15 1
CP000447_3865 CDS_4657311-4658651 53.0 1.1e-14 1
CP000447_0310 CDS_340562-339162 51.7 2.7e-14 1
CP000447_0483 CDS_551424-549967 50.8 4.7e-14 1
CP000447_1610 CDS_1932550-1930379 49.8 8.8e-14 1
CP000447_1560 CDS_1874303-1875808 48.8 1.8e-13 1
CP000447_0217 CDS_240880-239540 48.5 2.1e-13 1
CP000447_1459 CDS_1757008-1760430 46.3 9e-13 1
CP000447_3143 CDS_3792362-3795868 44.8 2.3e-12 1
CP000447_3037 CDS_3670162-3668852 44.4 3e-12 1
CP000447_3878 CDS_4676154-4674010 42.9 8e-12 1
CP000447_0091 CDS_104574-105815 35.9 7.8e-10 1
CP000447_1829 CDS_2175813-2177186 31.0 1.9e-08 1
CP000447_1816 CDS_2160281-2156724 30.4 2.7e-08 1
CP000447_0239 CDS_265533-266969 29.9 3.9e-08 1
CP000447_2696 CDS_3268802-3270598 27.9 1.4e-07 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000447_3468 1/1 721 786 .. 1 87 [] 96.0 7.2e-27
CP000447_2485 1/1 558 623 .. 1 87 [] 93.0 5.3e-26
CP000447_1037 1/1 320 385 .. 1 87 [] 92.4 7.5e-26
CP000447_1009 1/1 485 552 .. 1 87 [] 84.1 1.7e-23
CP000447_2790 1/1 902 967 .. 1 87 [] 82.1 6.3e-23
CP000447_3095 1/1 239 305 .. 1 87 [] 77.2 1.6e-21
CP000447_2745 1/1 205 271 .. 1 87 [] 77.0 1.8e-21
CP000447_1975 1/1 493 558 .. 1 87 [] 75.5 4.6e-21
CP000447_3969 1/1 275 340 .. 1 87 [] 74.2 1.1e-20
CP000447_0321 1/1 126 191 .. 1 87 [] 61.8 3.6e-17
CP000447_3640 1/1 220 289 .. 1 87 [] 59.8 1.3e-16
CP000447_1119 1/1 244 315 .. 1 87 [] 57.0 8e-16
CP000447_1169 1/1 134 200 .. 1 87 [] 54.7 3.6e-15
CP000447_3865 1/1 227 292 .. 1 87 [] 53.0 1.1e-14
CP000447_0310 1/1 246 308 .. 1 87 [] 51.7 2.7e-14
CP000447_0483 1/1 262 327 .. 1 87 [] 50.8 4.7e-14
CP000447_1610 1/1 497 562 .. 1 87 [] 49.8 8.8e-14
CP000447_1560 1/1 279 343 .. 1 87 [] 48.8 1.8e-13
CP000447_0217 1/1 235 295 .. 1 87 [] 48.5 2.1e-13
CP000447_1459 1/1 779 845 .. 1 87 [] 46.3 9e-13
CP000447_3143 1/1 776 841 .. 1 87 [] 44.8 2.3e-12
CP000447_3037 1/1 214 279 .. 1 87 [] 44.4 3e-12
CP000447_3878 1/1 474 541 .. 1 87 [] 42.9 8e-12
CP000447_0091 1/1 202 266 .. 1 87 [] 35.9 7.8e-10
CP000447_1829 1/1 220 281 .. 1 87 [] 31.0 1.9e-08
CP000447_1816 1/1 782 848 .. 1 87 [] 30.4 2.7e-08
CP000447_0239 1/1 250 316 .. 1 87 [] 29.9 3.9e-08
CP000447_2696 1/1 376 444 .. 1 87 [] 27.9 1.4e-07

Alignments of top-scoring domains:
CP000447_3468: domain 1 of 1, from 721 to 786: score 96.0, E = 7.2e-27
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHE+RTP++aI+g+++l+++ t l+ +q
CP000447_3 721 YKSEFLANMSHEIRTPMNAIIGMLQLAQR---------TSLTVQQ-- 756

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+++ +a++llr+ind+Ld+s+ieag
CP000447_3 757 ----------QDYLNKAGFSAQSLLRIINDILDFSKIEAG 786

CP000447_2485: domain 1 of 1, from 558 to 623: score 93.0, E = 5.3e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a+s flan+sHE+RTP++aI+g++++Ll+ + l++eq
CP000447_2 558 ARSAFLANMSHEIRTPMNAIIGFSDILLD---------DSLPAEQ-- 593

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l+ti ++a++ll+L+nd+Ld ++++ g
CP000447_2 594 ----------QKHLRTINQSAKSLLHLLNDVLDSAKLDKG 623

CP000447_1037: domain 1 of 1, from 320 to 385: score 92.4, E = 7.5e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g+a Ll+ t+l q
CP000447_1 320 IKSEFLANMSHELRTPLNGVIGFARQLLK---------TPLHTSQ-- 355

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+y++ti+r+a ll +ind+Ld+s++eag
CP000447_1 356 ----------LDYIKTIERSASNLLGIINDILDFSKLEAG 385

CP000447_1009: domain 1 of 1, from 485 to 552: score 84.1, E = 1.7e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fl+++sHELRTPL aI+g+a+l++ +t+++++ +
CP000447_1 485 AKSDFLSSMSHELRTPLGAILGFAQLMES--------STPAPPPAQ- 522

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ + il+++ +ll+Lin++Ldl+ ie+g
CP000447_1 523 ----------KRSIAQILKAGWYLLELINEILDLALIESG 552

CP000447_2790: domain 1 of 1, from 902 to 967: score 82.1, E = 6.3e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks flan+sHE+RTP++a++g+++l++ +++s +q
CP000447_2 902 AKSAFLANMSHEIRTPMNAVLGMLQLIQH---------SDMSRQQ-- 937

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++y+ +++++a++ll L+nd+Ld+s+i+ag
CP000447_2 938 ----------ADYVTKAENAAKSLLGLLNDILDFSKIDAG 967

CP000447_3095: domain 1 of 1, from 239 to 305: score 77.2, E = 1.6e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+f+a++sHELRTPL+aI+g+a+l + + l + +
CP000447_3 239 AKSDFMASMSHELRTPLNAILGLAQLYEY---------DVLANKVQ- 275

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ ++i+r++e+ll Lind+Ldl+ ie+g
CP000447_3 276 ----------KDNAKSIYRAGEHLLLLINDVLDLTAIESG 305

CP000447_2745: domain 1 of 1, from 205 to 271: score 77.0, E = 1.8e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +f+an+sHEL+TPLt+++gy+e++++ e + +
CP000447_2 205 MRKDFVANVSHELKTPLTVLQGYLEIMQT---------MEDADSPN- 241

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l+ +++++ r+++++++lL lsrie
CP000447_2 242 ----------HKPLSLMQQQTTRMQSMVEQLLALSRIEDA 271

CP000447_1975: domain 1 of 1, from 493 to 558: score 75.5, E = 4.6e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks fla++sHE+RTPL++++g++ lL ++l++ q
CP000447_1 493 AKSLFLATMSHEIRTPLNGLLGTLTLLSH---------SPLPPAQ-- 528

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l + ++ l++ +nd+Ld+sr+e+g
CP000447_1 529 ----------KQMLALSQYSGTLLQNVLNDILDFSRLEQG 558

CP000447_3969: domain 1 of 1, from 275 to 340: score 74.2, E = 1.1e-20
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aksefla +sHE+RTPL++I g+++lL +l+ e
CP000447_3 275 AKSEFLAVMSHEIRTPLNGIVGFSDLLTS---------FKLNKEV-- 310

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ i ++a+ ll L+n++Ld+s+++a+
CP000447_3 311 ----------SNTVQMINESAQTLLVLLNEVLDFSKADAN 340

CP000447_0321: domain 1 of 1, from 126 to 191: score 61.8, E = 3.6e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + +++nl+HE+++PL ++rg+a+lL + el+++++
CP000447_0 126 AAQFLVRNLAHEIKNPLGGLRGAAQLLSR----------ELDSPEL- 161

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e+++ i+++a+rl++L+++lL r +
CP000447_0 162 ----------KEFTSLIIEQADRLRNLVDRLLGPQRPTQH 191

CP000447_3640: domain 1 of 1, from 220 to 289: score 59.8, E = 1.3e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++fl ++sHELRTP+++Ir+++elL++ +++ s+e++
CP000447_3 220 REQQFLGYASHELRTPIAVIRTNTELLQK------LISKGGSAEKQ- 259

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ +++i+r++ + +L + lL l+r e
CP000447_3 260 ----------AQVVNRIERAGLTMTDLTETLLWLTRREGK 289

CP000447_1119: domain 1 of 1, from 244 to 315: score 57.0, E = 8e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkv.lagdtelseeqr
+ ++f a+++HEL+TPL+ I+++++ L + v + + +e +
CP000447_1 244 RERRFSADAAHELKTPLAIIKLHSDGLSD----VlSSQTPEIQQTT- 285

lpeLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y+e i + ++r+++ +++lL lsr +a
CP000447_1 286 -----------LPYIEAIGEGVNRISHTVEQLLLLSRVDAI 315

CP000447_1169: domain 1 of 1, from 134 to 200: score 54.7, E = 3.6e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a+++++a+l+H+ RTPL+a ++ya+ L ++ls+ r
CP000447_1 134 ALGKMVATLAHQVRTPLSAALLYASNLAS---------PKLSDSAR- 170

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ +++ + ++ l+r++nd+L ++r ++
CP000447_1 171 ----------SKFQSKLVDRLNELERQVNDMLLMARGRQD 200

CP000447_3865: domain 1 of 1, from 227 to 292: score 53.0, E = 1.1e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +f+a+++HELR P+ta+++ a+ L+ t l+++
CP000447_3 227 SQKRFIADAAHELRSPITALSLQAQRLQQ---------TQLTDDA-- 262

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ ++ + r +L+++lL ++r + +
CP000447_3 263 ----------RQKLNALQAGIGRSIHLLEQLLSMARQQDN 292

CP000447_0310: domain 1 of 1, from 246 to 308: score 51.7, E = 2.7e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++++ ++sHELRTPLt +++++ l ++ + +e+
CP000447_0 246 NQQRLMGDISHELRTPLTRLQLALALGRK---------KGQQSEE-- 281

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i ea +l++Li++lL+lsr
CP000447_0 282 -------------LERIGYEALQLEALISELLTLSRVSLA 308

CP000447_0483: domain 1 of 1, from 262 to 327: score 50.8, E = 4.7e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ak +fl +lsH+L+TPLta++gy+++ l + e +
CP000447_0 262 AKHDFLLHLSHDLKTPLTALLGYIDTWLI---------LPEHERD-- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +++ + ++++ l++L+ +lL+l+ +e+g
CP000447_0 298 ----------EALIQYAANSGQTLQQLLAQLLELAALENG 327

CP000447_1610: domain 1 of 1, from 497 to 562: score 49.8, E = 8.8e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + + lsHELRTP++++r +e L + l+e+
CP000447_1 497 YLENMSSRLSHELRTPVAVVRSSLEHLGL---------QQLDEQS-- 532

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++y++++++ + rl ++n+l + +r+ea
CP000447_1 533 ----------QKYVSRAQEGVSRLHLILNNLSEATRLEAS 562

CP000447_1560: domain 1 of 1, from 279 to 343: score 48.8, E = 1.8e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ak+++la++sHELRTPL+ + g +++++++ + ++ q
CP000447_1 279 AKNRWLADISHELRTPLSILCGEIDAIKAGI-------RTFDSTQ-- 316

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
l+++++e+ r+ +L++dl +ls + g
CP000447_1 317 -------------LNSLEQEVLRMKHLVDDLYELSLSDVG 343

CP000447_0217: domain 1 of 1, from 235 to 295: score 48.5, E = 2.1e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++a++sH+LRTPLt Ir+++e++ e ++q
CP000447_0 235 DRALLMAGISHDLRTPLTRIRLASEMMVE-------------DDQ-- 266

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e i ++e ++++in++ + r + +
CP000447_0 267 -----------YLKEGIVTDIEDMDAIINQFIAYIRNDRE 295

CP000447_1459: domain 1 of 1, from 779 to 845: score 46.3, E = 9e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k++fla++ H+L +PL+a r+++ L +++l+ e
CP000447_1 779 SKTRFLAAVGHDLMQPLNAARLFTASLSQ--------YPNLDLEA-- 815

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r l + ++++ +L+ dlLd+s++++g
CP000447_1 816 ----------RTTLTHVNSSLKIAGELLTDLLDISKLDSG 845

CP000447_3143: domain 1 of 1, from 776 to 841: score 44.8, E = 2.3e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k++fla++sH+L +P +a+ +++e+L+ +s e
CP000447_3 776 SKTRFLAAASHDLMQPFNALTLFTEMLKQ---------RVKSTEL-- 811

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ i+++++ ++L++dl ++sr++++
CP000447_3 812 ----------HDLATNIEDSLNVVESLLSDLVEISRLDSN 841

CP000447_3037: domain 1 of 1, from 214 to 279: score 44.4, E = 3e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +++sH+L+TP++ +r+ +e+L+e +++++ +
CP000447_3 214 DNKLLSRAVSHDLKTPIARLRFGIEALEE----------TQNPQLK- 249

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+y+++i r+++ +++L+ lL ++r+++g
CP000447_3 250 ----------IKYFQRINRDLDTMEDLVMTLLSYARLGQG 279

CP000447_3878: domain 1 of 1, from 474 to 541: score 42.9, E = 8e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++e++a+++HE+++P ++I+g+ elL+ el ++ +
CP000447_3 474 ALGELIAGIAHEINNPTAVILGNMELLKYEL-------GDNAAIV-- 511

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e +e +++++ r+ +i+ lL++sr ++
CP000447_3 512 ----------EEEIELVIQQVGRITTIIRSLLQYSRPGEF 541

CP000447_0091: domain 1 of 1, from 202 to 266: score 35.9, E = 7.8e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + + n++H+LRTPL+ +r +e L + ++e
CP000447_0 202 AVRGVTDNIAHDLRTPLSHLRIGIEQLSQ----------KPTAEL-- 236

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++ +l+e++++l + +L l+rie+g
CP000447_0 237 ----------ADATAELLEELDHCLGTFDAMLSLTRIEEG 266

CP000447_1829: domain 1 of 1, from 220 to 281: score 31.0, E = 1.9e-08
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ a ++H+L TPL+++r++++ L + t+ ++eq
CP000447_1 220 ALGTASAQMAHQLATPLATLRLLTDELVD---------THHDAEQ-- 255

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ ++++++r++ + dl r+ ++
CP000447_1 256 ----------MELISEMQQALNRCEVTLADL----RLATE 281

CP000447_1816: domain 1 of 1, from 782 to 848: score 30.4, E = 2.7e-08
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ks+ l++ sH+L +PL+a r+++++ ++ s ++
CP000447_1 782 KKSQYLRACSHDLLQPLSAARLFSSAVCL--------SSRVSRQE-- 818

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ ++ i++++e ++L+ dl +++rie+g
CP000447_1 819 ----------RQQIKQIDNSLEIANNLLLDLNEIARIESG 848

CP000447_0239: domain 1 of 1, from 250 to 316: score 29.9, E = 3.9e-08
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +a+++HEL+TP++ ++ ++e+ + +++qr+
CP000447_0 250 TEKRITADIAHELKTPISELISLSEIYIR-----------YPDDQRI 285

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ y + +l+ + r+ ++n+lL l ++ ++
CP000447_0 286 G---------VSYKQDVLSISLRMKTIVNNLLLLQQATSE 316

CP000447_2696: domain 1 of 1, from 376 to 444: score 27.9, E = 1.4e-07
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ + a++ HEL++PL+a+r ya+ +++ + e++
CP000447_2 376 VIGSLSASINHELNQPLAALRSYAQNTQTFI-------GRNMIEDA- 414

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++++ ++rl ++i ++ ++r +g
CP000447_2 415 ----------SSNIKIMIELTDRLADIIGQFKSFTRKSQG 444


Histogram of all scores:
score obs exp (one = represents 13 sequences)
----- --- ---
-15 2 0|=
-14 8 0|=
-13 45 3|*===
-12 181 92|=======*======
-11 399 477|=============================== *
-10 700 886|====================================================== *
-9 750 914|==========================================================*
-8 671 685|====================================================*
-7 512 431|=================================*======
-6 302 248|===================*====
-5 184 136|==========*====
-4 109 72|=====*===
-3 61 38|==*==
-2 32 20|=*=
-1 20 10|*=
0 10 5|*
1 4 2|*
2 1 1|*
3 0 0|
4 1 0|=
5 2 0|=
> 6 35 -|===


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 260.8968
P(chi-square) = 0

Total sequences searched: 4029

Whole sequence top hits:
tophits_s report:
Total hits: 28
Satisfying E cutoff: 28
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 28
Satisfying E cutoff: 28
Total memory: 32K


Acknowledgements:

This research is funded by:

Developed by: