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Thermotogae
Classification of phyla is from NCBI page
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76 projects found  

2 accessions found for Burkholderia mallei NCTC 10229  

Data for CP000546  

Available Atlases
Other Plots
hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000546.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000546_0557 CDS_595722-594376 92.0 8.1e-26 1
CP000546_0761 CDS_802112-799248 66.0 1.8e-18 1
CP000546_2358 CDS_2448586-2450103 61.8 3e-17 1
CP000546_3001 CDS_3095876-3097018 61.8 3e-17 1
CP000546_1591 CDS_1662422-1663888 60.0 9.8e-17 1
CP000546_2388 CDS_2476902-2478218 56.0 1.3e-15 1
CP000546_2959 CDS_3053862-3055175 54.5 3.5e-15 1
CP000546_0463 CDS_501280-499361 52.5 1.3e-14 1
CP000546_1820 CDS_1897359-1895980 49.7 7.9e-14 1
CP000546_3020 CDS_3123252-3120595 42.1 1.2e-11 1
CP000546_2235 CDS_2310473-2312881 41.3 1.9e-11 1
CP000546_3251 CDS_3380525-3379188 39.7 5.4e-11 1
CP000546_2131 CDS_2195765-2194485 27.1 2e-07 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000546_0557 1/1 218 284 .. 1 87 [] 92.0 8.1e-26
CP000546_0761 1/1 638 709 .. 1 87 [] 66.0 1.8e-18
CP000546_2358 1/1 271 336 .. 1 87 [] 61.8 3e-17
CP000546_3001 1/1 152 220 .. 1 87 [] 61.8 3e-17
CP000546_1591 1/1 233 298 .. 1 87 [] 60.0 9.8e-17
CP000546_2388 1/1 213 278 .. 1 87 [] 56.0 1.3e-15
CP000546_2959 1/1 219 277 .. 1 87 [] 54.5 3.5e-15
CP000546_0463 1/1 30 95 .. 1 87 [] 52.5 1.3e-14
CP000546_1820 1/1 238 304 .. 1 87 [] 49.7 7.9e-14
CP000546_3020 1/1 636 706 .. 1 87 [] 42.1 1.2e-11
CP000546_2235 1/1 540 612 .. 1 87 [] 41.3 1.9e-11
CP000546_3251 1/1 227 286 .. 1 87 [] 39.7 5.4e-11
CP000546_2131 1/1 201 270 .. 1 87 [] 27.1 2e-07

Alignments of top-scoring domains:
CP000546_0557: domain 1 of 1, from 218 to 284: score 92.0, E = 8.1e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+an+sHEL+TPLt+++g++e+++e +ls+++r
CP000546_0 218 MRRDFVANVSHELKTPLTVLSGFLETMRE---------LPLSDDER- 254

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yle ++++a r+++++ dlL l+++e +
CP000546_0 255 ----------ARYLELMEQQASRMRHIVTDLLVLAKLEGE 284

CP000546_0761: domain 1 of 1, from 638 to 709: score 66.0, E = 1.8e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +l+++sH+LRTPLtaI g++++L + + g t +++ r
CP000546_0 638 LRNSLLSAISHDLRTPLTAIVGLSSMLAN-----ARGATREGSPARE 679

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ i++ea r+ ++ +lLd++r++ag
CP000546_0 680 ----------DELVDAIHDEALRMTGIVTNLLDMARLQAG 709

CP000546_2358: domain 1 of 1, from 271 to 336: score 61.8, E = 3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +f+a+++H+++TPL+++r+ ae +l+ +e +++
CP000546_2 271 LQKRFIADAAHQMKTPLAGLRTQAEFALR---------HEVNADV-- 306

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ le i ++e+ rL+ +lL l+r+e+
CP000546_2 307 ----------AHSLEQIATSSEQAARLVTQLLALARAENR 336

CP000546_3001: domain 1 of 1, from 152 to 220: score 61.8, E = 3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++nl+HE+++PL +Irg+a+lL+ el +e+ +++
CP000546_3 152 VNKQLIRNLAHEIKNPLGGIRGAAQLLEFEL-------GERERDEL- 190

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
rey+++i++e++rl+ L+++lL+ r +
CP000546_3 191 ----------REYTQVIIKESDRLQTLVDRLLEPHRHPHI 220

CP000546_1591: domain 1 of 1, from 233 to 298: score 60.0, E = 9.8e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a+++f+a+++H+LRTPLtaI+++ae + +++++q+
CP000546_1 233 AQRKFIADAAHQLRTPLTAIKLHAEQAAV----------ARDPQQA- 268

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ ++++a+r rL n+lL l+r+e g
CP000546_1 269 ----------LTAVRELRSAADRAVRLSNQLLSLARAEPG 298

CP000546_2388: domain 1 of 1, from 213 to 278: score 56.0, E = 1.3e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+a++ a+l + ++++ r
CP000546_2 213 TQKAFVADAAHELRTPLAAVQIQAQLVAR----------AQDDVSR- 248

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
re++ +++ + r rL ++lL l+r+e g
CP000546_2 249 ----------REAIVDLQSGVTRATRLAEQLLALARAEPG 278

CP000546_2959: domain 1 of 1, from 219 to 277: score 54.5, E = 3.5e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +la+++H+LRTPL+ +r+ ae++ +
CP000546_2 219 DRAVMLAGVAHDLRTPLARMRLRAEMMDD------------------ 247

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + + r+++++ ++++++L ++ +a
CP000546_2 248 ----------ARLRDGVVRDVDSMTHIVDQFLVFAHGDAD 277

CP000546_0463: domain 1 of 1, from 30 to 95: score 52.5, E = 1.3e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + la++sHELR P++++++++el + + l +eq
CP000546_0 30 ASRGSLATASHELRAPVNGMLALVELVRQ---------GLLAPEQ-- 65

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++++++l r +nd+Ld + ieag
CP000546_0 66 ----------QRLLGLVQDSGQSLARVLNDILDHASIEAG 95

CP000546_1820: domain 1 of 1, from 238 to 304: score 49.7, E = 7.9e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++f+a+++H+LRTP+++I + ++ ++ e ++ +
CP000546_1 238 TQRRFIADAAHQLRTPIAVIDTQIQCARQ---------RENGDAAL- 274

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +l +++r+++r+ + + lL l+ +ea
CP000546_1 275 ----------AALLASMQRSSRRMADVTDKLLLLAHAEAA 304

CP000546_3020: domain 1 of 1, from 636 to 706: score 42.1, E = 1.2e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++e++++++HEL++PL+aI y++ l+ l +++ +s+e++
CP000546_3 636 TMGEMASSIAHELNQPLAAINNYCSGTLA-----LVKSGRASPETL- 676

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +le+ ++a r ++ +++++ + ++
CP000546_3 677 ----------APALEKTAQQALRAGMIVKRIREFVKRSEP 706

CP000546_2235: domain 1 of 1, from 540 to 612: score 41.3, E = 1.9e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a +e ++ l+HE+++PLt I++ ae L+++l +++ls ++ +
CP000546_2 540 AWGEVARRLAHEIKNPLTPIQLSAERLQMKL------SDKLSQPD-A 579

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ L ++ ti +++ + r+++d++d++r
CP000546_2 580 DVL-------KRGATTIVNQVAAMKRMVDDFRDYARTPPA 612

CP000546_3251: domain 1 of 1, from 227 to 286: score 39.7, E = 5.4e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +la++sH+LRTPL+ +r+ +e+ +
CP000546_3 227 DRALMLAGISHDLRTPLARLRLETEMSPSD----------------- 256

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + +++e+++r+i + d++r +
CP000546_3 257 ----------QATKDAMVDDIEQMDRIIAAFIDYARPAQR 286

CP000546_2131: domain 1 of 1, from 201 to 270: score 27.1, E = 2e-07
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ +a+++HE+ TPL++I +++e L+e a +t+++
CP000546_2 201 ALGVQAATVAHEMGTPLSTIAMLTEELRE------AARTDAGLAR-- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y l++++++ ++ + + +l+ + +
CP000546_2 240 ---------YDADLKVLEEQMSQCTSALARLRSRASERPS 270


Histogram of all scores:
score obs exp (one = represents 12 sequences)
----- --- ---
-15 1 0|=
-14 24 0|==
-13 65 2|*=====
-12 174 76|======*========
-11 316 395|=========================== *
-10 554 732|=============================================== *
-9 653 756|======================================================= *
-8 598 566|===============================================*==
-7 381 357|=============================*==
-6 248 205|=================*===
-5 144 112|=========*==
-4 68 60|====*=
-3 50 31|==*==
-2 23 16|=*
-1 7 8|*
0 9 4|*
1 1 2|*
2 1 1|*
3 0 0|
> 4 16 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 234.1449
P(chi-square) = 1.088e-313

Total sequences searched: 3333

Whole sequence top hits:
tophits_s report:
Total hits: 13
Satisfying E cutoff: 13
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 13
Satisfying E cutoff: 13
Total memory: 26K


Acknowledgements:

This research is funded by:

Developed by: