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Thermotogae
Classification of phyla is from NCBI page
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76 projects found  

2 accessions found for Burkholderia mallei NCTC 10247  

Data for CP000548  

Available Atlases
Other Plots
hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000548.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000548_0566 CDS_565436-566746 92.0 8.4e-26 1
CP000548_0362 CDS_358897-361761 66.0 1.9e-18 1
CP000548_0018 CDS_19230-20747 61.8 3.1e-17 1
CP000548_1486 CDS_1522488-1521346 61.8 3.1e-17 1
CP000548_2919 CDS_2941591-2940125 60.0 1e-16 1
CP000548_0049 CDS_47507-48823 56.0 1.4e-15 1
CP000548_1534 CDS_1564502-1563189 54.5 3.6e-15 1
CP000548_0668 CDS_659787-661751 52.5 1.4e-14 1
CP000548_2640 CDS_2657140-2658519 49.7 8.3e-14 1
CP000548_1468 CDS_1495262-1497769 42.1 1.2e-11 1
CP000548_2303 CDS_2318667-2321075 41.3 2e-11 1
CP000548_1222 CDS_1237720-1239078 39.7 5.6e-11 1
CP000548_3368 CDS_3388570-3387290 27.1 2.1e-07 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000548_0566 1/1 206 272 .. 1 87 [] 92.0 8.4e-26
CP000548_0362 1/1 638 709 .. 1 87 [] 66.0 1.9e-18
CP000548_0018 1/1 271 336 .. 1 87 [] 61.8 3.1e-17
CP000548_1486 1/1 152 220 .. 1 87 [] 61.8 3.1e-17
CP000548_2919 1/1 233 298 .. 1 87 [] 60.0 1e-16
CP000548_0049 1/1 213 278 .. 1 87 [] 56.0 1.4e-15
CP000548_1534 1/1 219 277 .. 1 87 [] 54.5 3.6e-15
CP000548_0668 1/1 45 110 .. 1 87 [] 52.5 1.4e-14
CP000548_2640 1/1 238 304 .. 1 87 [] 49.7 8.3e-14
CP000548_1468 1/1 586 656 .. 1 87 [] 42.1 1.2e-11
CP000548_2303 1/1 540 612 .. 1 87 [] 41.3 2e-11
CP000548_1222 1/1 234 293 .. 1 87 [] 39.7 5.6e-11
CP000548_3368 1/1 201 270 .. 1 87 [] 27.1 2.1e-07

Alignments of top-scoring domains:
CP000548_0566: domain 1 of 1, from 206 to 272: score 92.0, E = 8.4e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+an+sHEL+TPLt+++g++e+++e +ls+++r
CP000548_0 206 MRRDFVANVSHELKTPLTVLSGFLETMRE---------LPLSDDER- 242

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yle ++++a r+++++ dlL l+++e +
CP000548_0 243 ----------ARYLELMEQQASRMRHIVTDLLVLAKLEGE 272

CP000548_0362: domain 1 of 1, from 638 to 709: score 66.0, E = 1.9e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +l+++sH+LRTPLtaI g++++L + + g t +++ r
CP000548_0 638 LRNSLLSAISHDLRTPLTAIVGLSSMLAN-----ARGATREGSPARE 679

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ i++ea r+ ++ +lLd++r++ag
CP000548_0 680 ----------DELVDAIHDEALRMTGIVTNLLDMARLQAG 709

CP000548_0018: domain 1 of 1, from 271 to 336: score 61.8, E = 3.1e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +f+a+++H+++TPL+++r+ ae +l+ +e +++
CP000548_0 271 LQKRFIADAAHQMKTPLAGLRTQAEFALR---------HEVNADV-- 306

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ le i ++e+ rL+ +lL l+r+e+
CP000548_0 307 ----------AHSLEQIATSSEQAARLVTQLLALARAENR 336

CP000548_1486: domain 1 of 1, from 152 to 220: score 61.8, E = 3.1e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++nl+HE+++PL +Irg+a+lL+ el +e+ +++
CP000548_1 152 VNKQLIRNLAHEIKNPLGGIRGAAQLLEFEL-------GERERDEL- 190

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
rey+++i++e++rl+ L+++lL+ r +
CP000548_1 191 ----------REYTQVIIKESDRLQTLVDRLLEPHRHPHI 220

CP000548_2919: domain 1 of 1, from 233 to 298: score 60.0, E = 1e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a+++f+a+++H+LRTPLtaI+++ae + +++++q+
CP000548_2 233 AQRKFIADAAHQLRTPLTAIKLHAEQAAV----------ARDPQQA- 268

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ ++++a+r rL n+lL l+r+e g
CP000548_2 269 ----------LTAVRELRSAADRAVRLSNQLLSLARAEPG 298

CP000548_0049: domain 1 of 1, from 213 to 278: score 56.0, E = 1.4e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+a++ a+l + ++++ r
CP000548_0 213 TQKAFVADAAHELRTPLAAVQIQAQLVAR----------AQDDVSR- 248

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
re++ +++ + r rL ++lL l+r+e g
CP000548_0 249 ----------REAIVDLQSGVTRATRLAEQLLALARAEPG 278

CP000548_1534: domain 1 of 1, from 219 to 277: score 54.5, E = 3.6e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +la+++H+LRTPL+ +r+ ae++ +
CP000548_1 219 DRAVMLAGVAHDLRTPLARMRLRAEMMDD------------------ 247

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + + r+++++ ++++++L ++ +a
CP000548_1 248 ----------ARLRDGVVRDVDSMTHIVDQFLVFAHGDAD 277

CP000548_0668: domain 1 of 1, from 45 to 110: score 52.5, E = 1.4e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + la++sHELR P++++++++el + + l +eq
CP000548_0 45 ASRGSLATASHELRAPVNGMLALVELVRQ---------GLLAPEQ-- 80

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++++++l r +nd+Ld + ieag
CP000548_0 81 ----------QRLLGLVQDSGQSLARVLNDILDHASIEAG 110

CP000548_2640: domain 1 of 1, from 238 to 304: score 49.7, E = 8.3e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++f+a+++H+LRTP+++I + ++ ++ e ++ +
CP000548_2 238 TQRRFIADAAHQLRTPIAVIDTQIQCARQ---------RENGDAAL- 274

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +l +++r+++r+ + + lL l+ +ea
CP000548_2 275 ----------AALLASMQRSSRRMADVTDKLLLLAHAEAA 304

CP000548_1468: domain 1 of 1, from 586 to 656: score 42.1, E = 1.2e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++e++++++HEL++PL+aI y++ l+ l +++ +s+e++
CP000548_1 586 TMGEMASSIAHELNQPLAAINNYCSGTLA-----LVKSGRASPETL- 626

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +le+ ++a r ++ +++++ + ++
CP000548_1 627 ----------APALEKTAQQALRAGMIVKRIREFVKRSEP 656

CP000548_2303: domain 1 of 1, from 540 to 612: score 41.3, E = 2e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a +e ++ l+HE+++PLt I++ ae L+++l +++ls ++ +
CP000548_2 540 AWGEVARRLAHEIKNPLTPIQLSAERLQMKL------SDKLSQPD-A 579

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ L ++ ti +++ + r+++d++d++r
CP000548_2 580 DVL-------KRGATTIVNQVAAMKRMVDDFRDYARTPPA 612

CP000548_1222: domain 1 of 1, from 234 to 293: score 39.7, E = 5.6e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ +la++sH+LRTPL+ +r+ +e+ +
CP000548_1 234 DRALMLAGISHDLRTPLARLRLETEMSPSD----------------- 263

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + +++e+++r+i + d++r +
CP000548_1 264 ----------QATKDAMVDDIEQMDRIIAAFIDYARPAQR 293

CP000548_3368: domain 1 of 1, from 201 to 270: score 27.1, E = 2.1e-07
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ +a+++HE+ TPL++I +++e L+e a +t+++
CP000548_3 201 ALGVQAATVAHEMGTPLSTIAMLTEELRE------AARTDAGLAR-- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y l++++++ ++ + + +l+ + +
CP000548_3 240 ---------YDADLKVLEEQMSQCTSALARLRSRASERPS 270


Histogram of all scores:
score obs exp (one = represents 12 sequences)
----- --- ---
-14 30 0|===
-13 74 2|*======
-12 184 79|======*=========
-11 352 412|============================== *
-10 593 764|================================================== *
-9 676 789|========================================================= *
-8 605 591|=================================================*=
-7 385 372|==============================*==
-6 251 214|=================*===
-5 150 117|=========*===
-4 69 62|=====*
-3 50 33|==*==
-2 24 17|=*
-1 7 9|*
0 8 4|*
1 1 2|*
2 1 1|*
3 0 0|
> 4 16 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 229.0068
P(chi-square) = 1.294e-312

Total sequences searched: 3476

Whole sequence top hits:
tophits_s report:
Total hits: 13
Satisfying E cutoff: 13
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 13
Satisfying E cutoff: 13
Total memory: 26K


Acknowledgements:

This research is funded by:

Developed by: