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Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
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3 accessions found for   

Data for CP000577  

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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000577.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000577_0025 CDS_32793-35342 86.6 2.4e-24 1
CP000577_1549 CDS_1640933-1639893 85.3 5.7e-24 1
CP000577_1790 CDS_1903057-1900373 79.6 2.4e-22 1
CP000577_0217 CDS_240440-237873 77.8 7.9e-22 1
CP000577_2908 CDS_3082346-3085009 73.3 1.5e-20 1
CP000577_0311 CDS_332152-333870 67.7 5.5e-19 1
CP000577_1711 CDS_1817135-1814526 64.8 3.8e-18 1
CP000577_1061 CDS_1104579-1102852 64.1 5.7e-18 1
CP000577_2125 CDS_2270059-2271390 61.6 3e-17 1
CP000577_1516 CDS_1599188-1596987 57.4 4.6e-16 1
CP000577_1447 CDS_1521364-1520258 56.0 1.2e-15 1
CP000577_2090 CDS_2233697-2231385 48.0 2.1e-13 1
CP000577_1823 CDS_1935717-1934398 48.0 2.1e-13 1
CP000577_1241 CDS_1297860-1299293 46.4 5.9e-13 1
CP000577_1445 CDS_1518791-1516530 45.2 1.3e-12 1
CP000577_0171 CDS_186150-187538 44.2 2.6e-12 1
CP000577_0795 CDS_812527-814341 43.1 5.3e-12 1
CP000577_2550 CDS_2706590-2704605 41.9 1.1e-11 1
CP000577_2254 CDS_2407847-2406765 40.7 2.5e-11 1
CP000577_2699 CDS_2862669-2861269 37.6 1.9e-10 1
CP000577_2147 CDS_2291247-2294072 33.7 2.4e-09 1
CP000577_2949 CDS_3129189-3126340 28.5 7.1e-08 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000577_0025 1/1 338 403 .. 1 87 [] 86.6 2.4e-24
CP000577_1549 1/1 115 182 .. 1 87 [] 85.3 5.7e-24
CP000577_1790 1/1 668 734 .. 1 87 [] 79.6 2.4e-22
CP000577_0217 1/1 366 431 .. 1 87 [] 77.8 7.9e-22
CP000577_2908 1/1 663 730 .. 1 87 [] 73.3 1.5e-20
CP000577_0311 1/1 343 408 .. 1 87 [] 67.7 5.5e-19
CP000577_1711 1/1 367 433 .. 1 87 [] 64.8 3.8e-18
CP000577_1061 1/1 206 271 .. 1 87 [] 64.1 5.7e-18
CP000577_2125 1/1 196 291 .. 1 87 [] 61.6 3e-17
CP000577_1516 1/1 374 439 .. 1 87 [] 57.4 4.6e-16
CP000577_1447 1/1 133 197 .. 1 87 [] 56.0 1.2e-15
CP000577_2090 1/1 399 465 .. 1 87 [] 48.0 2.1e-13
CP000577_1823 1/1 233 291 .. 1 87 [] 48.0 2.1e-13
CP000577_1241 1/1 84 149 .. 1 87 [] 46.4 5.9e-13
CP000577_1445 1/1 505 576 .. 1 87 [] 45.2 1.3e-12
CP000577_0171 1/1 211 277 .. 1 87 [] 44.2 2.6e-12
CP000577_0795 1/1 380 448 .. 1 87 [] 43.1 5.3e-12
CP000577_2550 1/1 434 504 .. 1 87 [] 41.9 1.1e-11
CP000577_2254 1/1 136 200 .. 1 87 [] 40.7 2.5e-11
CP000577_2699 1/1 244 308 .. 1 87 [] 37.6 1.9e-10
CP000577_2147 1/1 537 601 .. 1 87 [] 33.7 2.4e-09
CP000577_2949 1/1 444 510 .. 1 87 [] 28.5 7.1e-08

Alignments of top-scoring domains:
CP000577_0025: domain 1 of 1, from 338 to 403: score 86.6, E = 2.4e-24
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks flan+sHE+RTP+++I g+a+lL e t l+e+q
CP000577_0 338 AKSAFLANMSHEIRTPMNGIVGMADLLCE---------TVLTEDQ-- 373

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r + eti++++e ll +ind+Ld+s+iea+
CP000577_0 374 ----------RLFSETIRSSGEALLVIINDILDYSKIEAN 403

CP000577_1549: domain 1 of 1, from 115 to 182: score 85.3, E = 5.7e-24
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++f+an+sHELRTPLta++g++e+L+ ++++++ ++
CP000577_1 115 IRRDFVANVSHELRTPLTALLGFIETLQG---------AARDDPAAR 152

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++l ++ rea r++rL++dlL lsr e++
CP000577_1 153 ----------SRFLGIMAREAGRMNRLVQDLLSLSRVESE 182

CP000577_1790: domain 1 of 1, from 668 to 734: score 79.6, E = 2.4e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k+ fl+ +sHELRTP+t+Ir+++e+L + ++l++e +
CP000577_1 668 QKDAFLSQISHELRTPMTSIRAFSEILMD---------GDLPPEMA- 704

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ ++i++ea rl rL++dlLdls +e+g
CP000577_1 705 ----------ARHARIIHDEAIRLTRLLDDLLDLSVLENG 734

CP000577_0217: domain 1 of 1, from 366 to 431: score 77.8, E = 7.9e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k +fla +sHE+RTPL+++ g +elL t+l++ q
CP000577_0 366 TKADFLAVMSHEMRTPLNGLAGSLELLAQ---------TPLDPRQ-- 401

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
re++++++ +ae ll+ +n +Ld++r ea
CP000577_0 402 ----------RELVSVLRASAEILLDHVNSVLDIARSEAR 431

CP000577_2908: domain 1 of 1, from 663 to 730: score 73.3, E = 1.5e-20
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +l+++sH+LRTPL +I+g+a L e ++l++e +
CP000577_2 663 LRTALLSSVSHDLRTPLVTIIGAAGSLAE--------PGALPPEAQ- 700

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + eti++e+erl+r +++lLd++r+++g
CP000577_2 701 ----------QALAETIREEGERLDRYVQNLLDMTRLGHG 730

CP000577_0311: domain 1 of 1, from 343 to 408: score 67.7, E = 5.5e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++f+a+++HE+++PL+++r ++ +++ +++ ++
CP000577_0 343 ANEQFAADVAHEIKNPLASLRSAVGTMRL---------AKREDQR-- 378

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l++i+++++rl+rL++d+ sr++++
CP000577_0 379 ----------EQLLDVIEHDVRRLDRLVSDISNASRLDSE 408

CP000577_1711: domain 1 of 1, from 367 to 433: score 64.8, E = 3.8e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla +sHE+RTPL++++++++lL++ +t+l++ q
CP000577_1 367 AKSRFLAVMSHEMRTPLNGLMAASDLLQT--------STDLTDRQ-- 403

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r ++++++ ++ l+++n++L+l+r+
CP000577_1 404 ----------RWLTDIVIGCGSAALDQVNNVLELTRLSDK 433

CP000577_1061: domain 1 of 1, from 206 to 271: score 64.1, E = 5.7e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k++fla +sHELRTPL+aI+g ++ l+ ++ ++
CP000577_1 206 TKDRFLAQMSHELRTPLNAILGIGHAELR---------GASDPVS-- 241

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l +++r+ae l+ +++d+Ld+s ++g
CP000577_1 242 ----------RDRLGVLIRSAEGLSTMLDDILDMSAVQQG 271

CP000577_2125: domain 1 of 1, from 196 to 291: score 61.6, E = 3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldk..v.lagdtelsee
+++++la+++HEL++P++ + ++a++L +++ k ++ + + ++ +
CP000577_2 196 SLGRLLAGVAHELNNPISFVYANAHALGRYATKfeQyFEQVQAGAPR 242

qrlpeLR.l.....edpeyreyletilreaerllrLindlLdlsrieag<
++l +LR++ + ++e+++ r++++ +++ aer +++++dl+ ls ++g
CP000577_2 243 EALIRLReElkldrEVRNLRDAVQGARDGAERVRDIVEDLRRLSSEGSG 291

-*

CP000577_2 - -

CP000577_1516: domain 1 of 1, from 374 to 439: score 57.4, E = 4.6e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s+f+a++sH+L +PL+a ++++ ++ + ++ +e
CP000577_1 374 SRSRFVAAASHDLLQPLSAAKLFIATIGD---------EAVAPES-- 409

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
re+l ++++++++ + ++ lLd+s++e+g
CP000577_1 410 ----------REALTKAQKALDSVEGILGALLDISKLESG 439

CP000577_1447: domain 1 of 1, from 133 to 197: score 56.0, E = 1.2e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++ +l+HE+++PL++I+g+a+l+ + +ls+e+
CP000577_1 133 SAIGMAEMLAHEIKNPLAGISGAAQLIAM----------NLSAED-- 167

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
re+ + i +e++r+ +L++++ ++ ++ +
CP000577_1 168 ----------RELADLIVEETRRIVKLLEQVEQFGNLRPP 197

CP000577_2090: domain 1 of 1, from 399 to 465: score 48.0, E = 2.1e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++ +++H++++ LtaI+g+++lLl ++++ +++
CP000577_2 399 AIGQLAGGIAHDFNNLLTAISGHCDLLLL--------RHDREDPE-- 435

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
l i++ a+r +L+ +lL +sr ++
CP000577_2 436 ----------FADLVQIHQNANRAASLVGQLLAFSRKQTL 465

CP000577_1823: domain 1 of 1, from 233 to 291: score 48.0, E = 2.1e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++ +l+++sH+LRTPLt +r+ +++L + +++
CP000577_1 233 QRTLMLSGVSHDLRTPLTRLRLGLSMLSD-------------PDE-- 264

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +l ++ ++rL++++L + r +a
CP000577_1 265 -------------GQELLGDVADMERLVDEFLSFVRGDAL 291

CP000577_1241: domain 1 of 1, from 84 to 149: score 46.4, E = 5.9e-13
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks+fl+++sH+L +PL+a +++++ L e t + q
CP000577_1 84 SKSRFLRAASHDLLQPLSAAKLFLSHLSE---------TVNEPLQ-- 119

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++++++i + ++ ++Li+ lL++sr+++
CP000577_1 120 ----------ADLVSRIGTAFDSTEELIRALLEISRLDSV 149

CP000577_1445: domain 1 of 1, from 505 to 576: score 45.2, E = 1.3e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++ ++ ++HE+++PLt I++ ae +++++ +l eq+
CP000577_1 505 AWGDVARRIAHEIKNPLTPIQLSAERIKRKF-------RPLVGEQAG 544

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +y ++i+r+++ l+r+++++ ++r+ ++
CP000577_1 545 DL--------DQYSDVIIRQTNDLRRIVDEFSKFARMPEP 576

CP000577_0171: domain 1 of 1, from 211 to 277: score 44.2, E = 2.6e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +a+++HEL TPL++I++ ++ L e else+ +l
CP000577_0 211 DLGGVVAAAAHELGTPLATIKLVSSELAE----------ELSEQPAL 247

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ e i+++a+r++++++ + + + +
CP000577_0 248 ----------RDDAELIREQADRCRDILRSMGRAGKDDLQ 277

CP000577_0795: domain 1 of 1, from 380 to 448: score 43.1, E = 5.3e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++e+ a++sHEL++PL+a+++y+ ++ l ++ee
CP000577_0 380 ALGEMSAAVSHELNQPLAAMKTYLAGAKLLLQ------RRRTEEA-- 418

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++i++ +er+ ++ ++l ++r + +
CP000577_0 419 ----------LASFQRIDDLIERMGAITRQLKSYARKGGE 448

CP000577_2550: domain 1 of 1, from 434 to 504: score 41.9, E = 1.1e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++e++++l+HEL++PL+aI ya + + l++ + +++ +
CP000577_2 434 TLGEMASTLAHELNQPLAAIASYAAGAAN-----LLRQERADPALL- 474

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+l ++ ++a+r ++i+++ dl r +++
CP000577_2 475 ----------SSALAKLSHQADRAGQIIRRIQDLVRKREP 504

CP000577_2254: domain 1 of 1, from 136 to 200: score 40.7, E = 2.5e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ ++++HELRTPLt +rg ++ Ll+ + +
CP000577_2 136 ELAYSNSAIAHELRTPLTILRGRLQGLLD---------GVFEPGP-- 171

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ ++++ ++ l+ ++++l++l+ ag
CP000577_2 172 -----------QVYRRLIAHVDDLSGIVEELRTLALSNAG 200

CP000577_2699: domain 1 of 1, from 244 to 308: score 37.6, E = 1.9e-10
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++ +a +sH+LR+ Lt+ +++a+ L + ++
CP000577_2 244 QLGGAVAKISHDLRNILTTAQLFADRLSA----------SDDPAV-- 278

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ ++ +++r +L + L++ r+e++
CP000577_2 279 ----------ARAAPKLVGSIRRAVSLCESTLTFGRAEEP 308

CP000577_2147: domain 1 of 1, from 537 to 601: score 33.7, E = 2.4e-09
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++++l+H+L++ L+aI g a l+++ l + +
CP000577_2 537 VIGQLASGLAHDLNNLLAAIGGSALLIQD-----------LQSGAA- 571

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ ++il ++e+ +L++++L+l + +++
CP000577_2 572 ----------EVHAQRILAATEQAGALVRRFLTLGKRQSN 601

CP000577_2949: domain 1 of 1, from 444 to 510: score 28.5, E = 7.1e-08
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a + ++ +++H++++ L +I g ++l l+ +l+e++++
CP000577_2 444 AIGNLAGGIAHDFNNLLQTITGSIQLSLR----------ALDEDHAA 480

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r l+ +lr++er L ++lL + r +
CP000577_2 481 ----------RPRLDQALRAVERGATLASQLLAFGRRQPL 510


Histogram of all scores:
score obs exp (one = represents 11 sequences)
----- --- ---
-14 4 0|=
-13 25 2|*==
-12 92 67|======*==
-11 244 352|======================= *
-10 454 653|========================================== *
-9 617 675|========================================================= *
-8 543 505|=============================================*====
-7 410 318|============================*=========
-6 226 183|================*====
-5 146 100|=========*====
-4 83 53|====*===
-3 47 28|==*==
-2 17 14|=*
-1 18 7|*=
0 11 4|*
1 6 2|*
2 2 1|*
3 1 0|=
4 1 0|=
5 0 0|
6 0 0|
> 7 26 -|===


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 208.9764
P(chi-square) = 1.925e-308

Total sequences searched: 2973

Whole sequence top hits:
tophits_s report:
Total hits: 22
Satisfying E cutoff: 22
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 22
Satisfying E cutoff: 22
Total memory: 29K


Acknowledgements:

This research is funded by:

Developed by: