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Classification of phyla is from NCBI page
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264 projects found  

2 accessions found for Vibrio cholerae O395  

Data for CP000627  

Available Atlases
Other Plots
hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000627.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000627_0937 CDS_995083-999078 97.7 1.6e-27 1
CP000627_1981 CDS_2187779-2190562 94.5 1.3e-26 1
CP000627_1393 CDS_1526804-1524594 90.9 1.3e-25 1
CP000627_0236 CDS_263688-264989 81.5 6.4e-23 1
CP000627_1027 CDS_1100035-1101579 79.8 2e-22 1
CP000627_1898 CDS_2080914-2078557 76.0 2.3e-21 1
CP000627_0141 CDS_152553-149020 74.7 5.4e-21 1
CP000627_1229 CDS_1338606-1335166 71.3 4.8e-20 1
CP000627_2261 CDS_2475260-2476324 60.6 5.4e-17 1
CP000627_0909 CDS_962100-960778 58.5 2.1e-16 1
CP000627_2599 CDS_2853357-2856800 56.5 7.5e-16 1
CP000627_1685 CDS_1844291-1843236 56.4 8.4e-16 1
CP000627_1484 CDS_1628844-1630637 52.4 1.1e-14 1
CP000627_2227 CDS_2442248-2440932 51.0 2.9e-14 2
CP000627_2207 CDS_2414364-2415758 50.2 4.7e-14 1
CP000627_1100 CDS_1190427-1188394 39.9 4e-11 1
CP000627_0702 CDS_753470-751515 29.3 3.9e-08 2

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000627_0937 1/1 606 671 .. 1 87 [] 97.7 1.6e-27
CP000627_1981 1/1 290 355 .. 1 87 [] 94.5 1.3e-26
CP000627_1393 1/1 356 421 .. 1 87 [] 90.9 1.3e-25
CP000627_0236 1/1 205 272 .. 1 87 [] 81.5 6.4e-23
CP000627_1027 1/1 153 217 .. 1 87 [] 79.8 2e-22
CP000627_1898 1/1 282 347 .. 1 87 [] 76.0 2.3e-21
CP000627_0141 1/1 507 575 .. 1 87 [] 74.7 5.4e-21
CP000627_1229 1/1 621 686 .. 1 87 [] 71.3 4.8e-20
CP000627_2261 1/1 131 196 .. 1 87 [] 60.6 5.4e-17
CP000627_0909 1/1 212 277 .. 1 87 [] 58.5 2.1e-16
CP000627_2599 1/1 788 853 .. 1 87 [] 56.5 7.5e-16
CP000627_1685 1/1 125 191 .. 1 87 [] 56.4 8.4e-16
CP000627_1484 1/1 373 441 .. 1 87 [] 52.4 1.1e-14
CP000627_2207 1/1 247 309 .. 1 87 [] 50.2 4.7e-14
CP000627_2227 2/2 226 286 .. 1 87 [] 49.3 8.5e-14
CP000627_1100 1/1 445 512 .. 1 87 [] 39.9 4e-11

Alignments of top-scoring domains:
CP000627_0937: domain 1 of 1, from 606 to 671: score 97.7, E = 1.6e-27
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
ak++flan+sHE+RTP++aI+g+a+l+l+ t+l+ q
CP000627_0 606 AKGDFLANMSHEIRTPMNAILGMAHLALN---------TPLDTTQ-- 641

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+y+ +i ++a+ ll +ind+Ld+s++eag
CP000627_0 642 ----------RKYVTRINESAKNLLGIINDILDFSKMEAG 671

CP000627_1981: domain 1 of 1, from 290 to 355: score 94.5, E = 1.3e-26
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g++ +l+ t l+ q
CP000627_1 290 VKSEFLANMSHELRTPLNGVIGFTRQMLK---------TQLTNSQ-- 325

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+ti+++a+ ll +ind+Ld+s++eag
CP000627_1 326 ----------ADYLQTIEKSANNLLTIINDILDFSKLEAG 355

CP000627_1393: domain 1 of 1, from 356 to 421: score 90.9, E = 1.3e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks fla+lsHE+RTP+++++g+a++Ll+ +el+++q
CP000627_1 356 AKSAFLATLSHEIRTPMNGVLGTAQILLK---------DELTSKQ-- 391

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l ++++++e++ +L+n++Ld+s+ie+g
CP000627_1 392 ----------RQHLTSLYESGEHMMSLLNEILDYSKIEQG 421

CP000627_0236: domain 1 of 1, from 205 to 272: score 81.5, E = 6.4e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++ f+an+sHELRTP+t+++gy+e+ ++ ++ +
CP000627_0 205 MRRNFFANVSHELRTPMTVLQGYLEMTED---------PDVLAGP-- 240

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ ++ ++ ++++r+++L+n+lL+ls+iea
CP000627_0 241 --------MWSKAHGVMTEQLNRMNSLVNQLLTLSKIEAS 272

CP000627_1027: domain 1 of 1, from 153 to 217: score 79.8, E = 2e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks fla++sHELRTPL+a++g++++L+ e ++ q
CP000627_1 153 SKSNFLAMMSHELRTPLNAVLGLIDILRG----------ESTSYQ-- 187

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+le ++++ae ll +ind+Ldlsrie+g
CP000627_1 188 ----------VELLEQMENSAELLLIIINDILDLSRIESG 217

CP000627_1898: domain 1 of 1, from 282 to 347: score 76.0, E = 2.3e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+ f++++sHELRTPL++I g++ +Ll+ t+ls+eq
CP000627_1 282 DKTTFISTISHELRTPLNGIVGLSRMLLD---------TPLSSEQ-- 317

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ti +a l ++ nd+ d+ + +
CP000627_1 318 ----------RKHLQTINVSAVTLGNIFNDIIDMDKFDRR 347

CP000627_0141: domain 1 of 1, from 507 to 575: score 74.7, E = 5.4e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+efla+ sHELRTPL++++g ae+L +++ ++ s+ +
CP000627_0 507 LKDEFLATTSHELRTPLHGMIGIAEALISGAN------GPISAAH-- 545

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ l++i+++++rl L++dlLd+ +++ g
CP000627_0 546 ----------KYQLDIIISSGQRLATLVDDLLDYHKMRYG 575

CP000627_1229: domain 1 of 1, from 621 to 686: score 71.3, E = 4.8e-20
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ fla +sHELRTP++a++g+ e+L +++e
CP000627_1 621 ARNHFLAVVSHELRTPIAAMLGLMEILAS---------RLKNSES-- 656

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +l ++++aerl +nd+Ld+s+iea+
CP000627_1 657 ----------QLLLTNAISSAERLKLHVNDILDFSKIEAQ 686

CP000627_2261: domain 1 of 1, from 131 to 196: score 60.6, E = 5.4e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++l+HE+++PL ++rg+a+lL++ l+++ +
CP000627_2 131 AAKLLVRGLAHEIKNPLGGLRGAAQLLER----------MLPDPAL- 166

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
ey+++i+++a+rl+ L+++lL r ++
CP000627_2 167 ----------MEYTQIIIEQADRLRGLVDRLLGPQRPGEK 196

CP000627_0909: domain 1 of 1, from 212 to 277: score 58.5, E = 2.1e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++ +++H+LRTP+ I+ ae+L e + l+++q
CP000627_0 212 SNKALTNAIAHDLRTPIFRIQWQAEVLAE---------SQLNAKQ-- 247

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ + +i++++e ++ ++++lL ++++e++
CP000627_0 248 ----------QQQVASIIEDTEEMETMVDELLYYAKLEHP 277

CP000627_2599: domain 1 of 1, from 788 to 853: score 56.5, E = 7.5e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks+fla++sH+L +PL+a r++a+ L e ++ +e
CP000627_2 788 SKSRFLAAVSHDLMQPLNAARLFASSLSE---------VAKEAEV-- 823

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + i++++ ++Li+dlLd+sr+e+g
CP000627_2 824 ----------QKLAHHIESALGAAEDLISDLLDISRLESG 853

CP000627_1685: domain 1 of 1, from 125 to 191: score 56.4, E = 8.4e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++++a+l+H+ RTPL++ ++ya L + ++l++ +r
CP000627_1 125 SLGRMVASLAHQVRTPLSSAMLYAANLAA---------PNLPPATR- 161

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ +++ + ++ l++++nd+L +++ + +
CP000627_1 162 ----------ERFQSKLVDRLHDLEKQVNDMLLFAKGGDN 191

CP000627_1484: domain 1 of 1, from 373 to 441: score 52.4, E = 1.1e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++ a++sHEL++PL+aIr +a+ +++l t+++e
CP000627_1 373 VLGQMSASISHELNNPLAAIRSFADNGRRFLA------TNKPERA-- 411

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e l++i +er+ ++ ++l ++r +
CP000627_1 412 ----------EENLSRISALTERMAKISEQLKSFARKSTS 441

CP000627_2207: domain 1 of 1, from 247 to 309: score 50.2, E = 4.7e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++l+++sHELR PLt +r++ l+ + s+ +
CP000627_2 247 GQQRLLSDISHELRSPLTRLRMANALAMR---------KLGSSSE-- 282

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i+ ea+rl+++i dlL lsr++ +
CP000627_2 283 -------------LERIDTEAQRLEQMIGDLLALSRMQIN 309

CP000627_2227: domain 2 of 2, from 226 to 286: score 49.3, E = 8.5e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++a++sH++RTPLt Ir+++e++ e+
CP000627_2 226 DRALLMAGISHDIRTPLTRIRLATEMMSP--------------ED-- 256

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e+i++++e ++++i++++d+ + +
CP000627_2 257 ----------SYLAESIISDTEECNQIISQFMDYLKPVNR 286

CP000627_1100: domain 1 of 1, from 445 to 512: score 39.9, E = 4e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++e++a+++HE+++P ++I+g++el++ el ++ +
CP000627_1 445 ALGELTAGIAHEINNPTAVILGNTELIRFEL-------GADASRV-- 482

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e ++ il ++er++++ + lL++sr +
CP000627_1 483 ----------EEEIDAILLQIERIRNITRSLLQYSRQGGV 512


Histogram of all scores:
score obs exp (one = represents 9 sequences)
----- --- ---
-15 1 0|=
-14 19 0|===
-13 42 2|*====
-12 114 62|======*======
-11 229 325|========================== *
-10 463 602|==================================================== *
-9 499 622|======================================================== *
-8 467 466|===================================================*
-7 326 293|================================*====
-6 215 169|==================*=====
-5 122 92|==========*===
-4 82 49|=====*====
-3 60 26|==*====
-2 36 13|=*==
-1 20 7|*==
0 13 3|*=
1 2 1|*
2 3 1|*
3 5 0|=
4 1 0|=
5 0 0|
6 2 0|=
7 0 0|
8 0 0|
> 9 21 -|===


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 276.0896
P(chi-square) = 0

Total sequences searched: 2742

Whole sequence top hits:
tophits_s report:
Total hits: 17
Satisfying E cutoff: 17
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 16
Satisfying E cutoff: 16
Total memory: 27K


Acknowledgements:

This research is funded by:

Developed by: