Acidobacteria Actinobacteria Alphaproteobacteria
Aquificae Bacteroidetes/Chlorobi Betaproteobacteria
Chlamydiae/Verrucomicrobia Chloroflexi Cyanobacteria
Deinococcus-Thermus Deltaproteobacteria Epsilonproteobacteria
Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
Search:
264 projects found  

1 accessions found for Escherichia coli ATCC 8739  

Data for CP000946  

Available Atlases
Other Plots
hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000946.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000946_0907 CDS_1005649-1002893 100.1 5.1e-28 1
CP000946_3167 CDS_3541757-3540462 91.0 2e-25 1
CP000946_1277 CDS_1426709-1423116 81.6 9e-23 1
CP000946_2545 CDS_2853767-2856481 80.7 1.6e-22 1
CP000946_1407 CDS_1576644-1579493 80.6 1.8e-22 1
CP000946_0479 CDS_535335-537671 78.9 5.4e-22 1
CP000946_1406 CDS_1576477-1574651 76.4 2.8e-21 1
CP000946_1100 CDS_1221825-1223252 75.4 5.3e-21 1
CP000946_1534 CDS_1730229-1728826 69.8 2.1e-19 1
CP000946_4016 CDS_4530325-4531698 66.6 1.6e-18 1
CP000946_3933 CDS_4431328-4429952 61.5 4.5e-17 1
CP000946_3012 CDS_3362453-3363901 61.0 6.3e-17 1
CP000946_3340 CDS_3728909-3727509 60.8 7e-17 1
CP000946_3356 CDS_3745984-3747459 60.7 7.6e-17 1
CP000946_0659 CDS_724083-722734 60.7 7.8e-17 1
CP000946_4056 CDS_4575729-4576778 59.7 1.5e-16 1
CP000946_2899 CDS_3231887-3234574 59.6 1.5e-16 1
CP000946_3580 CDS_4007254-4005830 59.4 1.8e-16 1
CP000946_0299 CDS_359059-360411 55.0 3.1e-15 1
CP000946_1641 CDS_1879017-1880375 52.3 1.8e-14 1
CP000946_3829 CDS_4301187-4302287 45.0 2.1e-12 1
CP000946_1977 CDS_2233610-2232309 42.4 1.2e-11 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000946_0907 1/1 292 357 .. 1 87 [] 100.1 5.1e-28
CP000946_3167 1/1 203 269 .. 1 87 [] 91.0 2e-25
CP000946_1277 1/1 711 777 .. 1 87 [] 81.6 9e-23
CP000946_2545 1/1 433 498 .. 1 87 [] 80.7 1.6e-22
CP000946_1407 1/1 469 534 .. 1 87 [] 80.6 1.8e-22
CP000946_0479 1/1 282 347 .. 1 87 [] 78.9 5.4e-22
CP000946_1406 1/1 388 453 .. 1 87 [] 76.4 2.8e-21
CP000946_1100 1/1 249 317 .. 1 87 [] 75.4 5.3e-21
CP000946_1534 1/1 240 304 .. 1 87 [] 69.8 2.1e-19
CP000946_4016 1/1 238 300 .. 1 87 [] 66.6 1.6e-18
CP000946_3933 1/1 237 303 .. 1 87 [] 61.5 4.5e-17
CP000946_3012 1/1 261 327 .. 1 87 [] 61.0 6.3e-17
CP000946_3340 1/1 247 313 .. 1 87 [] 60.8 7e-17
CP000946_3356 1/1 262 328 .. 1 87 [] 60.7 7.6e-17
CP000946_0659 1/1 236 302 .. 1 87 [] 60.7 7.8e-17
CP000946_4056 1/1 129 186 .. 1 79 [. 59.7 1.5e-16
CP000946_2899 1/1 663 730 .. 1 87 [] 59.6 1.5e-16
CP000946_3580 1/1 255 320 .. 1 87 [] 59.4 1.8e-16
CP000946_0299 1/1 233 293 .. 1 87 [] 55.0 3.1e-15
CP000946_1641 1/1 235 301 .. 1 87 [] 52.3 1.8e-14
CP000946_3829 1/1 145 205 .. 1 87 [] 45.0 2.1e-12
CP000946_1977 1/1 211 271 .. 1 87 [] 42.4 1.2e-11

Alignments of top-scoring domains:
CP000946_0907: domain 1 of 1, from 292 to 357: score 100.1, E = 5.1e-28
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g++ l l+ tel++ q
CP000946_0 292 IKSEFLANMSHELRTPLNGVIGFTRLTLK---------TELTPTQ-- 327

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ti+r+a+ ll++ind+Ld+s++eag
CP000946_0 328 ----------RDHLNTIERSANNLLAIINDVLDFSKLEAG 357

CP000946_3167: domain 1 of 1, from 203 to 269: score 91.0, E = 2e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ f+an+sHELRTPLt+++gy+e++ e ++l r
CP000946_3 203 ARRNFFANVSHELRTPLTVLQGYLEMMDE---------QPLEGAVR- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l+t++++++r++ L+ +lL+ls+iea
CP000946_3 240 ----------EKALHTMREQTQRMEGLVKQLLTLSKIEAA 269

CP000946_1277: domain 1 of 1, from 711 to 777: score 81.6, E = 9e-23
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks+fla++sHE+RTP+++I+g++elL + ls eqr
CP000946_1 711 AKSQFLATMSHEIRTPISSIMGFLELLSG---------SGLSKEQR- 747

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
e+++ ++ +++ll Li ++Ld +ie+g
CP000946_1 748 ----------VEAISLAYATGQSLLGLIGEILDVDKIESG 777

CP000946_2545: domain 1 of 1, from 433 to 498: score 80.7, E = 1.6e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks fla++sHE+RTPL +I+g+a+lL + ++ q
CP000946_2 433 AKSAFLAAMSHEIRTPLYGILGTAQLLAD---------NPALNAQ-- 468

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ i +++e+ll ++nd+Ld+s ieag
CP000946_2 469 ----------RDDLRAITDSGESLLTILNDILDYSAIEAG 498

CP000946_1407: domain 1 of 1, from 469 to 534: score 80.6, E = 1.8e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks fla++sHELRTPL +I+g+++lL++ el+
CP000946_1 469 SKSMFLATVSHELRTPLYGIIGNLDLLQT---------KELPKGV-- 504

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + +++ ll++i+d+Ld+s+ie++
CP000946_1 505 ----------DRLVTAMNNSSSLLLKIISDILDFSKIESE 534

CP000946_0479: domain 1 of 1, from 282 to 347: score 78.9, E = 5.4e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+ f++++sHELRTPL++I g++ +Ll+ tel++eq
CP000946_0 282 DKTTFISTISHELRTPLNGIVGLSRILLD---------TELTAEQ-- 317

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+ti+ +a l ++ nd+ d+ ++e
CP000946_0 318 ----------EKYLKTIHVSAVTLGNIFNDIIDMDKMERR 347

CP000946_1406: domain 1 of 1, from 388 to 453: score 76.4, E = 2.8e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++e++a+++HE R+PLtaIrgy+++L+ ++ ++ +
CP000946_1 388 TLGELMAGVAHEVRNPLTAIRGYVQILRQ---------QTSDPIH-- 423

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+eyl+++l+e++++++ i++lL++sr ++
CP000946_1 424 ----------QEYLSVVLKEIDSINKVIQQLLEFSRPRHS 453

CP000946_1100: domain 1 of 1, from 249 to 317: score 75.4, E = 5.3e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +fl++lsHEL+TPL+++r +elL +++ ++l++eq
CP000946_1 249 QRHQFLRHLSHELKTPLASMREGTELLADQV------VGPLTPEQ-- 287

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e +++++++++ l++Li++lLd+ r +a
CP000946_1 288 ----------KEVVSILDSSSRNLQKLIEQLLDYNRKQAD 317

CP000946_1534: domain 1 of 1, from 240 to 304: score 69.8, E = 2.1e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+a++sHELRTPL+++rg +e++++++ + ++e+
CP000946_1 240 MRRDFMADISHELRTPLAVLRGELEAIQDGV-------RKFTPET-- 277

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +++ e+ l +L++dl +ls ++g
CP000946_1 278 -------------VASLQAEVGTLTKLVDDLHQLSMSDEG 304

CP000946_4016: domain 1 of 1, from 238 to 300: score 66.6, E = 1.6e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++++l+++sHELRTPLt +++ + lL++ +++
CP000946_4 238 SQQRLLSDISHELRTPLTRLQLGTALLRR---------RSGESKE-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i+ ea+rl+++indlL +sr ++
CP000946_4 274 -------------LERIETEAQRLDSMINDLLVMSRNQQK 300

CP000946_3933: domain 1 of 1, from 237 to 303: score 61.5, E = 4.5e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++a+++HE+R+PL++I+g+a+ e +++++ e
CP000946_3 237 ALGHLAAGVAHEIRNPLSSIKGLAKYFAE--------RAPAGGEA-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ +++ +ea+rl+r +++lL+l + +
CP000946_3 274 ----------HQLAQVMAKEADRLNRVVSELLELVKPTHL 303

CP000946_3012: domain 1 of 1, from 261 to 327: score 61.0, E = 6.3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s f a+++HE+RTP+t +++ +e++l + +s +++
CP000946_3 261 RQSNFSADIAHEIRTPITNLITQTEIALS---------QSRSQKEL- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e+ r+ ++++d+L l++++++
CP000946_3 298 ----------EDVLYSNLEELTRMAKMVSDMLFLAQADNN 327

CP000946_3340: domain 1 of 1, from 247 to 313: score 60.8, E = 7e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+s+f ++++HELRTP++ +++ ++ +l+ e++ +
CP000946_3 247 KLSDFSSDIAHELRTPVSNLMMQTQFALA---------KERDVSH-- 282

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
yre+l l+e++rl+r+ +d+L l+r e+g
CP000946_3 283 ---------YREILFANLEELKRLSRMTSDMLFLARSEHG 313

CP000946_3356: domain 1 of 1, from 262 to 328: score 60.7, E = 7.6e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ f a+++HE+RTP+t + + +e++l ++++ +++
CP000946_3 262 RQANFSADIAHEIRTPITNLVTQTEIALS---------QDRTQKEL- 298

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e +r+ ++++d+L l++++++
CP000946_3 299 ----------EDVLYSSLEEYNRMTKMVSDMLFLAQADNN 328

CP000946_0659: domain 1 of 1, from 236 to 302: score 60.7, E = 7.8e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++f+++++HELR PLta++ +e+++ ++ +++ r
CP000946_0 236 RERRFTSDAAHELRSPLTALKVQTEVAQL---------SDDDPQAR- 272

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++ ++r rL+++lL+lsr+++
CP000946_0 273 ----------KKALLQLHSGIDRATRLVDQLLTLSRLDSL 302

CP000946_4056: domain 1 of 1, from 129 to 186: score 59.7, E = 1.5e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++++l+HE+++PL ++rg+a+lL + +l+++ +
CP000946_4 129 AARDLVRGLAHEIKNPLGGLRGAAQLLSK----------ALPDPSL- 164

peLRledpeyreyletilreaerllrLindlL<-*
ey+++i+++a+rl++L+++lL
CP000946_4 165 ----------LEYTKVIIEQADRLRNLVDRLL 186

CP000946_2899: domain 1 of 1, from 663 to 730: score 59.6, E = 1.5e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +la+lsH+LRTPLt++ g ae+L +l + ++++
CP000946_2 663 IRNALLAALSHDLRTPLTVLFGQAEILTLDL-------ASEGSPH-- 700

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ + i++ + rL+n+lLd++ri++g
CP000946_2 701 ----------ARQASEIRQHVLNTTRLVNNLLDMARIQSG 730

CP000946_3580: domain 1 of 1, from 255 to 320: score 59.4, E = 1.8e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + +l HEL+ PL+aIr +ae+L+e ++ +e
CP000946_3 255 YIEQYVYALTHELKSPLAAIRSAAEILRE---------GPPPEVV-- 290

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++++ il + r+++L++ lL +r+e+
CP000946_3 291 ----------ARFTDNILTQNARMQALVETLLRQARLENR 320

CP000946_0299: domain 1 of 1, from 233 to 293: score 55.0, E = 3.1e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ ++a++sH+LRTPLt Ir+++e++ e ++
CP000946_0 233 DRTLLMAGVSHDLRTPLTRIRLATEMMSE---------QD------- 263

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e+i +++e ++++i+++ d+ r +++
CP000946_0 264 ----------GYLAESINKDIEECNAIIEQFIDYLRTGQE 293

CP000946_1641: domain 1 of 1, from 235 to 301: score 52.3, E = 1.8e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s+f+ +l+HELRTP++a++g ++ l +++s +
CP000946_1 235 RLSQFADDLAHELRTPINALLGQNQVTLS---------QTRSIAE-- 270

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y++ + ++e+e ++rL +++L l+r++ +
CP000946_1 271 ---------YQKTIAGNIEELENISRLTENILFLARADKN 301

CP000946_3829: domain 1 of 1, from 145 to 205: score 45.0, E = 2.1e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+++r+++elL + t+
CP000946_3 145 NERLFTADVAHELRTPLAGVRLHLELLAK---------TH------- 175

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + ++++ + +++lL+l+r+++
CP000946_3 176 ----------HIDVAPLVARLDQMMESVSQLLQLARAGQS 205

CP000946_1977: domain 1 of 1, from 211 to 271: score 42.4, E = 1.2e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k +++ +++HELRTPL +r +e+ + ls+ +
CP000946_1 211 SKKQLIDGIAHELRTPLVRLRYRLEMSDN-----------LSAAE-- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + r++ +l++Li++lL+++r++ +
CP000946_1 245 -------------SQALNRDISQLEALIEELLTYARLDRP 271


Histogram of all scores:
score obs exp (one = represents 14 sequences)
----- --- ---
-14 9 0|=
-13 40 3|*==
-12 185 95|======*=======
-11 412 497|============================== *
-10 713 923|=================================================== *
-9 776 953|======================================================== *
-8 730 714|==================================================*==
-7 499 450|================================*===
-6 336 258|==================*=====
-5 223 142|==========*=====
-4 98 76|=====*=
-3 58 40|==*==
-2 29 21|=*=
-1 34 11|*==
0 14 5|*
1 6 2|*
2 12 1|*
3 2 0|=
4 0 0|
> 5 24 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 330.2081
P(chi-square) = 0

Total sequences searched: 4200

Whole sequence top hits:
tophits_s report:
Total hits: 22
Satisfying E cutoff: 22
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 22
Satisfying E cutoff: 22
Total memory: 29K


Acknowledgements:

This research is funded by:

Developed by: