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Firmicutes Fusobacteria Gammaproteobacteria
Other Bacteria Planctomycetes Spirochaetes
Thermotogae
Classification of phyla is from NCBI page
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264 projects found  

1 accessions found for Escherichia coli str. K-12 substr. DH10B  

Data for CP000948  

Available Atlases
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hmmsearch - search a sequence database with a profile HMM
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /home/projects/MicrobialGenomicsGroup/Packages/hmmdata-1.0.0.package/Resources/noarch/TCS/HisKA_1.hmm [HisKA]
Sequence database: CP000948.Gprot.fsa
per-sequence score cutoff: >= 26.8 [TC1]
per-domain score cutoff: >= 26.8 [TC2]
per-sequence Eval cutoff: [none]
per-domain Eval cutoff: [none]
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query HMM: HisKA
Accession: PF00512.12
Description: His Kinase A (phosphoacceptor) domain
[HMM has been calibrated; E-values are empirical estimates]

Scores for complete sequences (score includes all domains):
Sequence Description Score E-value N
-------- ----------- ----- ------- ---
CP000948_2751 CDS_3006957-3009713 100.1 5.1e-28 1
CP000948_0338 CDS_356444-357739 90.3 3.2e-25 1
CP000948_1019 CDS_1109329-1106585 80.7 1.6e-22 1
CP000948_2224 CDS_2408886-2406037 80.6 1.8e-22 1
CP000948_3143 CDS_3448792-3446456 78.9 5.4e-22 1
CP000948_2225 CDS_2409053-2410879 76.4 2.8e-21 1
CP000948_2554 CDS_2780885-2779458 75.4 5.3e-21 1
CP000948_2094 CDS_2251908-2253311 69.8 2.1e-19 1
CP000948_3787 CDS_4202695-4201322 66.6 1.6e-18 1
CP000948_4196 CDS_4681181-4682605 62.4 2.5e-17 1
CP000948_3869 CDS_4299645-4301042 61.5 4.5e-17 1
CP000948_0507 CDS_533325-531883 61.0 6.3e-17 1
CP000948_0613 CDS_646585-645143 61.0 6.3e-17 1
CP000948_2967 CDS_3266251-3267600 60.7 7.8e-17 1
CP000948_3746 CDS_4153282-4152233 59.7 1.5e-16 1
CP000948_0727 CDS_776229-773545 59.6 1.5e-16 1
CP000948_3320 CDS_3631635-3630283 55.0 3.1e-15 1
CP000948_1993 CDS_2127184-2125826 52.3 1.8e-14 1
CP000948_3969 CDS_4431657-4430566 45.0 2.1e-12 1
CP000948_1657 CDS_1771867-1773168 42.4 1.2e-11 1

Parsed for domains:
Sequence Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
CP000948_2751 1/1 292 357 .. 1 87 [] 100.1 5.1e-28
CP000948_0338 1/1 203 269 .. 1 87 [] 90.3 3.2e-25
CP000948_1019 1/1 443 508 .. 1 87 [] 80.7 1.6e-22
CP000948_2224 1/1 469 534 .. 1 87 [] 80.6 1.8e-22
CP000948_3143 1/1 282 347 .. 1 87 [] 78.9 5.4e-22
CP000948_2225 1/1 388 453 .. 1 87 [] 76.4 2.8e-21
CP000948_2554 1/1 249 317 .. 1 87 [] 75.4 5.3e-21
CP000948_2094 1/1 240 304 .. 1 87 [] 69.8 2.1e-19
CP000948_3787 1/1 238 300 .. 1 87 [] 66.6 1.6e-18
CP000948_4196 1/1 255 320 .. 1 87 [] 62.4 2.5e-17
CP000948_3869 1/1 244 310 .. 1 87 [] 61.5 4.5e-17
CP000948_0507 1/1 261 327 .. 1 87 [] 61.0 6.3e-17
CP000948_0613 1/1 261 327 .. 1 87 [] 61.0 6.3e-17
CP000948_2967 1/1 236 302 .. 1 87 [] 60.7 7.8e-17
CP000948_3746 1/1 129 186 .. 1 79 [. 59.7 1.5e-16
CP000948_0727 1/1 663 730 .. 1 87 [] 59.6 1.5e-16
CP000948_3320 1/1 233 293 .. 1 87 [] 55.0 3.1e-15
CP000948_1993 1/1 235 301 .. 1 87 [] 52.3 1.8e-14
CP000948_3969 1/1 142 202 .. 1 87 [] 45.0 2.1e-12
CP000948_1657 1/1 211 271 .. 1 87 [] 42.4 1.2e-11

Alignments of top-scoring domains:
CP000948_2751: domain 1 of 1, from 292 to 357: score 100.1, E = 5.1e-28
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
kseflan+sHELRTPL++++g++ l l+ tel++ q
CP000948_2 292 IKSEFLANMSHELRTPLNGVIGFTRLTLK---------TELTPTQ-- 327

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ti+r+a+ ll++ind+Ld+s++eag
CP000948_2 328 ----------RDHLNTIERSANNLLAIINDVLDFSKLEAG 357

CP000948_0338: domain 1 of 1, from 203 to 269: score 90.3, E = 3.2e-25
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ f+an+sHELRTPLt+++gy+e++ e ++l r
CP000948_0 203 ARRNFFANVSHELRTPLTVLQGYLEMMNE---------QPLEGAVR- 239

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l+t++++++r++ L+ +lL+ls+iea
CP000948_0 240 ----------EKALHTMREQTQRMEGLVKQLLTLSKIEAA 269

CP000948_1019: domain 1 of 1, from 443 to 508: score 80.7, E = 1.6e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
aks fla++sHE+RTPL +I+g+a+lL + ++ q
CP000948_1 443 AKSAFLAAMSHEIRTPLYGILGTAQLLAD---------NPALNAQ-- 478

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
r+ l+ i +++e+ll ++nd+Ld+s ieag
CP000948_1 479 ----------RDDLRAITDSGESLLTILNDILDYSAIEAG 508

CP000948_2224: domain 1 of 1, from 469 to 534: score 80.6, E = 1.8e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ks fla++sHELRTPL +I+g+++lL++ el+
CP000948_2 469 SKSMFLATVSHELRTPLYGIIGNLDLLQT---------KELPKGV-- 504

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ + +++ ll++i+d+Ld+s+ie++
CP000948_2 505 ----------DRLVTAMNNSSSLLLKIISDILDFSKIESE 534

CP000948_3143: domain 1 of 1, from 282 to 347: score 78.9, E = 5.4e-22
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
k+ f++++sHELRTPL++I g++ +Ll+ tel++eq
CP000948_3 282 DKTTFISTISHELRTPLNGIVGLSRILLD---------TELTAEQ-- 317

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++yl+ti+ +a l ++ nd+ d+ ++e
CP000948_3 318 ----------EKYLKTIHVSAVTLGNIFNDIIDMDKMERR 347

CP000948_2225: domain 1 of 1, from 388 to 453: score 76.4, E = 2.8e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++e++a+++HE R+PLtaIrgy+++L+ ++ ++ +
CP000948_2 388 TLGELMAGVAHEVRNPLTAIRGYVQILRQ---------QTSDPIH-- 423

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+eyl+++l+e++++++ i++lL++sr ++
CP000948_2 424 ----------QEYLSVVLKEIDSINKVIQQLLEFSRPRHS 453

CP000948_2554: domain 1 of 1, from 249 to 317: score 75.4, E = 5.3e-21
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +fl++lsHEL+TPL+++r +elL +++ ++l++eq
CP000948_2 249 QRHQFLRHLSHELKTPLASMREGTELLADQV------VGPLTPEQ-- 287

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+e +++++++++ l++Li++lLd+ r +a
CP000948_2 288 ----------KEVVSILDSSSRNLQKLIEQLLDYNRKQAD 317

CP000948_2094: domain 1 of 1, from 240 to 304: score 69.8, E = 2.1e-19
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++++f+a++sHELRTPL+++rg +e++++++ + ++e+
CP000948_2 240 MRRDFMADISHELRTPLAVLRGELEAIQDGV-------RKFTPET-- 277

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ +++ e+ l +L++dl +ls ++g
CP000948_2 278 -------------VASLQAEVGTLTKLVDDLHQLSMSDEG 304

CP000948_3787: domain 1 of 1, from 238 to 300: score 66.6, E = 1.6e-18
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+++++l+++sHELRTPLt +++ + lL++ +++
CP000948_3 238 SQQRLLSDISHELRTPLTRLQLGTALLRR---------RSGESKE-- 273

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
le+i+ ea+rl+++indlL +sr ++
CP000948_3 274 -------------LERIETEAQRLDSMINDLLVMSRNQQK 300

CP000948_4196: domain 1 of 1, from 255 to 320: score 62.4, E = 2.5e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ + +l HEL+ PL+aIrg+ae+L+e ++ +e
CP000948_4 255 YIEQYVYALTHELKSPLAAIRGAAEILRE---------GPPPEVV-- 290

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++++ il + r+++L++ lL +r+e+
CP000948_4 291 ----------ARFTDNILTQNARMQALVETLLRQARLENR 320

CP000948_3869: domain 1 of 1, from 244 to 310: score 61.5, E = 4.5e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a++ ++a+++HE+R+PL++I+g+a+ e +++++ e
CP000948_3 244 ALGHLAAGVAHEIRNPLSSIKGLAKYFAE--------RAPAGGEA-- 280

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++ +++ +ea+rl+r +++lL+l + +
CP000948_3 281 ----------HQLAQVMAKEADRLNRVVSELLELVKPTHL 310

CP000948_0507: domain 1 of 1, from 261 to 327: score 61.0, E = 6.3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s f a+++HE+RTP+t +++ +e++l + +s +++
CP000948_0 261 RQSNFSADIAHEIRTPITNLITQTEIALS---------QSRSQKEL- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e+ r+ ++++d+L l++++++
CP000948_0 298 ----------EDVLYSNLEELTRMAKMVSDMLFLAQADNN 327

CP000948_0613: domain 1 of 1, from 261 to 327: score 61.0, E = 6.3e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s f a+++HE+RTP+t +++ +e++l + +s +++
CP000948_0 261 RQSNFSADIAHEIRTPITNLITQTEIALS---------QSRSQKEL- 297

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ l + l+e+ r+ ++++d+L l++++++
CP000948_0 298 ----------EDVLYSNLEELTRMAKMVSDMLFLAQADNN 327

CP000948_2967: domain 1 of 1, from 236 to 302: score 60.7, E = 7.8e-17
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ ++f+++++HELR PLta++ +e+++ ++ +++ r
CP000948_2 236 RERRFTSDAAHELRSPLTALKVQTEVAQL---------SDDDPQAR- 272

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+++l +++ ++r rL+++lL+lsr+++
CP000948_2 273 ----------KKALLQLHSGIDRATRLVDQLLTLSRLDSL 302

CP000948_3746: domain 1 of 1, from 129 to 186: score 59.7, E = 1.5e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
a ++++++l+HE+++PL ++rg+a+lL + +l+++ +
CP000948_3 129 AARDLVRGLAHEIKNPLGGLRGAAQLLSK----------ALPDPSL- 164

peLRledpeyreyletilreaerllrLindlL<-*
ey+++i+++a+rl++L+++lL
CP000948_3 165 ----------LEYTKVIIEQADRLRNLVDRLL 186

CP000948_0727: domain 1 of 1, from 663 to 730: score 59.6, E = 1.5e-16
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ +la+lsH+LRTPLt++ g ae+L +l + ++++
CP000948_0 663 IRNALLAALSHDLRTPLTVLFGQAEILTLDL-------ASEGSPH-- 700

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
++ + i++ + rL+n+lLd++ri++g
CP000948_0 701 ----------ARQASEIRQHVLNTTRLVNNLLDMARIQSG 730

CP000948_3320: domain 1 of 1, from 233 to 293: score 55.0, E = 3.1e-15
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++ ++a++sH+LRTPLt Ir+++e++ e ++
CP000948_3 233 DRTLLMAGVSHDLRTPLTRIRLATEMMSE---------QD------- 263

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ e+i +++e ++++i+++ d+ r +++
CP000948_3 264 ----------GYLAESINKDIEECNAIIEQFIDYLRTGQE 293

CP000948_1993: domain 1 of 1, from 235 to 301: score 52.3, E = 1.8e-14
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
++s+f+ +l+HELRTP++a++g ++ l +++s +
CP000948_1 235 RLSQFADDLAHELRTPINALLGQNQVTLS---------QTRSIAE-- 270

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
y++ + ++e+e ++rL +++L l+r++ +
CP000948_1 271 ---------YQKTIAGNIEELENISRLTENILFLARADKN 301

CP000948_3969: domain 1 of 1, from 142 to 202: score 45.0, E = 2.1e-12
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+ f+a+++HELRTPL+++r+++elL + t+
CP000948_3 142 NERLFTADVAHELRTPLAGVRLHLELLAK---------TH------- 172

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + + ++++ + +++lL+l+r+++
CP000948_3 173 ----------HIDVAPLVARLDQMMESVSQLLQLARAGQS 202

CP000948_1657: domain 1 of 1, from 211 to 271: score 42.4, E = 1.2e-11
*->akseflanlsHELRTPLtaIrgyaelLleeldkvlagdtelseeqrl
+k +++ +++HELRTPL +r +e+ + ls+ +
CP000948_1 211 SKKQLIDGIAHELRTPLVRLRYRLEMSDN-----------LSAAE-- 244

peLRledpeyreyletilreaerllrLindlLdlsrieag<-*
+ + r++ +l++Li++lL+++r++ +
CP000948_1 245 -------------SQALNRDISQLEALIEELLTYARLDRP 271


Histogram of all scores:
score obs exp (one = represents 13 sequences)
----- --- ---
-16 1 0|=
-15 1 0|=
-14 14 0|==
-13 49 3|*===
-12 183 94|=======*=======
-11 428 489|================================= *
-10 709 907|======================================================= *
-9 766 936|==========================================================*
-8 700 701|=====================================================*
-7 497 442|=================================*=====
-6 318 254|===================*=====
-5 187 139|==========*====
-4 98 74|=====*==
-3 55 39|==*==
-2 31 20|=*=
-1 35 10|*==
0 17 5|*=
1 5 2|*
2 8 1|*
3 2 0|=
4 0 0|
> 5 22 -|==


% Statistical details of theoretical EVD fit:
mu = -8.9758
lambda = 0.6525
chi-sq statistic = 299.7948
P(chi-square) = 0

Total sequences searched: 4200

Whole sequence top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 21K

Domain top hits:
tophits_s report:
Total hits: 20
Satisfying E cutoff: 20
Total memory: 28K


Acknowledgements:

This research is funded by:

Developed by: