HExpoChem: a systems biology resource to explore human exposure to chemicals [ link ]
Olivier Taboureau, Ulrik Plesner Jacobsen, Christian Kalhauge, Daniel Edsgärd, Olga Rigina, Ramneek Gupta and Karine Audouze
Center for Biological Sequence Analysis, Department of Systems Biology,
The Technical University of Denmark, DK-2800 Lyngby, Denmark
Humans are exposed to diverse hazardous chemicals on a daily basis. Although an exposure to these chemicals is suspected to have adverse effects on human health, mechanistic insights into how they interact with the human body are still limited. Therefore, acquisition of curated data and development of computational biology approaches are needed in order to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical-protein interactions have been enriched with a quality scored human protein-protein interactions (PPI) network, a protein-protein associations network (PPAN) and a chemical-chemical interactions (CCI) network, thus allowing the study of environmental chemicals through formation of protein complexes and phenotypic outcomes enrichment.