InterMap3D: visualizing predicted co-evolving protein residues.
R. Gouveia-Oliveira*, F. Roque*, R. Wernersson, T. Sicheritz-Ponten, A. Mølgaard, P. W. Sackett, A. G. Pedersen.
* - these authors contributed equally to this work
Center for Biological Sequence Analysis, BioCentrum-DTU,
The Technical University of Denmark, DK-2800 Lyngby, Denmark
Summary: InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar Protein Data Bank (PDB) entry. It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: RCW Mutual Information, Mutual Information/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted.
Availability: The InterMap3D web-server is freely available at http://www.cbs.dtu.dk/services/InterMap3D/
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