LYRA: Lymphocyte Receptor Automated Modelling

The LYRA server predicts structures for either T-Cell Receptors (TCR) or B-Cell Receptors (BCR) using homology modelling. Framework templates are selected based on BLOSUM score, and complementary determining regions (CDR) are then selected if needed based on a canonical structure model and grafted onto the framework templates.

Submit data

Input a pair of TCR or BCR protein sequences in any order. One sequence per field, no fasta headers. After submission of sequences is complete, it is possible to manually select new templates and resubmit. Prediction of structure should take less than a few minutes depending on queue status.