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LipoP 1.0 Server

Prediction of lipoproteins and signal peptides in Gram negative bacteria

The LipoP 1.0 server produces predictions of lipoproteins and discriminates between lipoprotein signal peptides, other signal peptides and n-terminal membrane helices in Gram-negative bacteria.

Note: Although LipoP 1.0 has been trained on sequences from Gram-negative bacteria only, the following paper reports that it has a good performance on sequences from Gram-positive bacteria also:

Methods for the bioinformatic identification of bacterial lipoproteins encoded in the genomes of Gram-positive bacteria
O. Rahman, S. P. Cummings, D. J. Harrington and I. C. Sutcliffe
World Journal of Microbiology and Biotechnology 24(11):2377-2382 (2008)

Instructions Output format Article abstract


Paste a single sequence or several sequences in FASTA format into the field below:

Submit a file in FASTA format directly from your local disk:

Output format:    Extensive, with graphics
Extensive, no graphics

At most 5000 sequences and 500,000 amino acids per submission; each sequence not less than 70 and not more than 5,000 amino acids.

The sequences are kept confidential and will be deleted after processing.


For publication of results, please cite:

Prediction of lipoprotein signal peptides in Gram-negative bacteria.
A. S. Juncker, H. Willenbrock, G. von Heijne, H. Nielsen, S. Brunak and A. Krogh.
Protein Sci. 12(8):1652-62, 2003

View the abstract.


Would you prefer to run LipoP at your own site? LipoP 1.0 is available as a stand-alone software package, with the same functionality as the service above. For now only a Linux version exists. There is a download page for academic users; other users are requested to contact CBS Software Package Manager at


Scientific problems:        Technical problems: