Layers may be used in user-defined combinations. Please note that
missing values are allowed in the uploaded data, but should be denoted
by 'NA'. Please specify the gene ID nomenclature used in the input files uploaded to
Metaranker. Ensembl gene IDs (preferred), Hugo gene symbols and Entrez
gene IDs are supported. Please use space or tab as column separators.
The input file should consist of at least two columns
containing the dbSNP SNP ID and association p-value. Please specify
whether the file contains any header.
Please note that SNPs with non-valid p-values will be discarded and that
'NA' should be used for missing data in the p-value column.
1b. Format of SNP to gene mapping file
The SNP to gene mapping file should consist of exactely two columns and no
header. The first column should specify the dbSNP SNP ID, while the second
column should specify the associated gene.
Please specify a file containing phenotype-specific susceptiblity genes (one per line) or paste the genes into the formular field (one per line).
This file should contain three columns. The first column should contain
the chromosome, the second column should contain the chromosomal band, and the third
column should contain the LOD score reported in the original linkage study. If no LOD score are available, please use the value 1 for each interval. Please not that consequtive bands cannot be abreviated as e.g. 2q22-2q24 but needs to be formated as shown in the example below. Please indicated whether the file contains any header.
16 p12 2.8
2 q22 3.1
2 q23 3.1
2 q24 3.1
Please choose the risk-phenotype keyword that is resembling your
phenotype of interest most closely. If there is no good match please
leave the field unchanged.
This file should contain at least two columns, the first holding the gene
ID and the second holding the differential expression p-value. Please
indicate whether the file contains any header. If fold-changes should be
used rather than differential expression values please provide the list
of genes along with the absolut values of
their foldchanges and indicate the the list should be sorted descendingly.
6. Submit the job
Click on the "Submit"
button. The status of your job (either 'queued'
or 'running') will be displayed and constantly updated until it terminates and
the server output appears in the browser window.
At any time during the wait you may enter your e-mail address and simply leave
the window. Your job will continue; you will be notified by e-mail when it has
terminated. The e-mail message will contain the URL under which the results are
stored; they will remain on the server for 24 hours for you to collect them.