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NetCorona 1.0 Server

Prediction of Coronavirus 3CL Proteinase cleavage sites on amino acid sequences

NetCorona predicts coronavirus 3C-like proteinase (or protease) cleavage sites using artificial neural networks on amino acid sequences. Every potential site is scored and a list is compiled in addition to a graphical representation. Refer to publication for more detailed information and performance values.

Instructions Output format Article abstract

SUBMISSION

Paste a single sequence or several sequences in FASTA format into the field below:

Submit a file in FASTA format directly from your local disk:

Generate graphics   

Restrictions:
At most 10 sequences and 50,000 amino acids per submission; each sequence not more than 10,000 amino acids.

Confidentiality:
The sequences are kept confidential and will be deleted after processing.


CITATIONS

For publication of results, please cite:

Coronavirus 3CL-pro proteinase cleavage sites: Possible relevance to SARS virus pathology
L. Kiemer, O. Lund, S. Brunak, and N. Blom
BMC Bioinformatics 2004, 5:72

View the abstract         Download the PDF


PORTABLE VERSION

Would you prefer to run NetCorona at your own site? NetCorona 1.0 is available as a package on a commercial license. Currently available platforms include MIPS (under IRIX, Silicon Graphics), SPARC (under Solaris, Sun), Alpha (under OSF1) and Pentium family (under Linux and CYGWIN). Send inquiries by e-mail to software@cbs.dtu.dk.


KEYWORDS

SARS protease cleavage, SARS proteinase cleavage, Avian Infectious Bronchitis Virus (AIBV), Murine Hepatitis Virus (MHV), Human Coronavirus 229E (HCoV-229E), Porcine Epidemic Diarrhea Virus (PEDV), Bovine Coronavirus (BCoV), Transmissible Gastroenteritis Virus (TGV), polyprotein cleavage, host protein cleavage, virus pathology.


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