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NetMHC 2.0 Server

NetMHC 2.0 server predicts binding of peptides to a number of different HLA alleles using artificial neural networks (ANNs) and hidden markov models (HMMs).

Predictions can be obtained for 12 supertypes, and 120 individual alleles using matrices (ungapped HMMs) generated with data from public databases. Furthermore ANNs have been trained for 10 different alleles representing 7 supertypes.

       
The project is collaboration between CBS and IMMI.

Instructions Output format Article abstract

SUBMISSION

Paste a single sequence or several sequences in FASTA format into the field below:

Submit a file in FASTA format directly from your local disk:

Allele         Threshold         Sort by affinity 

Restrictions:
At most 5000 sequences per submission; each sequence not more than 20,000 amino acids and not less than 9 amino acids.

Confidentiality:
The sequences are kept confidential and will be deleted after processing.


CITATIONS

For publication of results, please cite:

Sensitive quantitative predictions of peptide-MHC binding by a 'Query by Committee' artificial neural network approach.
Buus S, Lauemoller SL, Worning P, Kesmir C, Frimurer T, Corbet S, Fomsgaard A, Hilden J,Holm A, Brunak S.
Tissue Antigens., 62:378-84, 2003.

View the abstract or the full text version at PMID: 14617044

Reliable prediction of T-cell epitopes using neural networks with novel sequence representations.
Nielsen M, Lundegaard C, Worning P, Lauemoller SL, Lamberth K, Buus S, Brunak S, Lund O.
Protein Sci., 12:1007-17, 2003.

View the abstract or the full text version at PMID: 12717023

Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach.
Nielsen M, Lundegaard C, Worning P, Hvid CS, Lamberth K, Buus S, Brunak S, Lund O.
Bioinformatics, 20(9):1388-97, 2004.

View the abstract or the full text version at PMID: 14962912


PORTABLE VERSION

Would you prefer to run NetMHC at your own site? The NetMHC 2.0 package is in preparation. It will soon be available for the most common UNIX platforms including MIPS (under IRIX, Silicon Graphics), SPARC (under Solaris, Sun), Alpha (under OSF1) and Pentium family (under Linux). Send inquiries by e-mail to software@cbs.dtu.dk.


GETTING HELP

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