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NetMHCIIpan 1.0 Server

NetMHCIIpan server predicts binding of peptides to more than 500 HLA-DR alleles using artificial neural networks (ANNs). The prediction values are given in nM IC50 values. The project is a collaboration between CBS and IMMI.

Instructions Output format Article abstract Data sets

SUBMISSION

Paste a single sequence or several sequences in FASTA or PEPTIDE format into the field below (if PEPTIDE click the box below. Note peptides must be of equal length):

Submit a file in FASTA or PEPTIDE format into the field below (if PEPTIDE format click the box below. Note peptides must be of equal length):

Click if input is PEPTIDE format 

Select allele - max 15 per submission (use ctrl key to select multiple alleles)


or type allele names (ie DRBX_XXXX) seperated by commas (max 15 per submission)  

Peptide length         Sort by affinity        Use fast mode (recommended for large calculations) 

Print only strongest binding core 

Save prediction to xls file 

(please be patient, the calculation might take a few minuts)

Restrictions:
At most 5000 sequences per submission; each sequence not more than 20,000 amino acids and not less than 9 amino acids.

Confidentiality:
The sequences are kept confidential and will be deleted after processing.


CITATIONS

For publication of results, please cite:

  • Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan.
    Nielsen M, Lundegaard C, Blicher T, Peters B, Sette A, Justesen S, Buus S, and Lund O. PLoS Comput Biol. 2008 Jul 4;4(7).

    View the abstract or the full text version at PMID: PLoS Computational Biology Full text


PORTABLE VERSION

Would you prefer to run NetMHCIIpan at your own site? NetMHCIIpan v. 1.0 is available as a stand-alone software package, with the same functionality as the service above. Ready-to-ship packages exist for the most common UNIX platforms. There is a download page for academic users; other users are requested to contact CBS Software Package Manager at software@cbs.dtu.dk.


GETTING HELP

Scientific problems:        Technical problems: