NetMHCpan 1.1 Server
NetMHCpan server predicts binding of peptides
to 478 and 791 different HLA A and B alleles using artificial neural networks
(ANNs). This is a beta version of the server, and it is in the process of being updated
with other features (prediction of user defined MHC molecules, ect)
Predictions can be made for 8-11 mer peptides. Note that all non 9mer predictions are
made using approximations. Most HLA molecules have a strong preference for binding 9mers.
The prediction values are given in nM IC50 values.
The project is a collaboration between CBS and
View the version history of this server.
All the previous versions are available on line, for comparison and
For publication of results, please cite:
NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of
Nielsen M, et al. (2007) PLoS ONE 2(8): e796. doi:10.1371/journal.pone.0000796
View the abstract, the full text version at PLoSONE:
Full text, or Full text including supplementary materials:
Data resources used to develop this server was obtained from
- IEDB database.
- Quantitative peptide binding data were obtained
from the IEDB database.
- IMGT/HLA database. Robinson J, Malik A, Parham P, Bodmer JG,
Marsh SGE: IMGT/HLA - a sequence database for the human major histocompatibility complex. Tissue Antigens (2000),
- HLA protein sequences were obtained from the IMGT/HLA database (version 2.17.0).
Would you prefer to run NetMHC:locifer at your own site? The NetMHC:locifer package is
in preparation. It will soon be available for the most common UNIX
MIPS (under IRIX, Silicon Graphics),
SPARC (under Solaris, Sun),
Alpha (under OSF1) and
Pentium family (under Linux).
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