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NetNES 1.1 Server

NetNES 1.1 server predicts leucine-rich nuclear export signals (NES) in eukaryotic proteins using a combination of neural networks and hidden Markov models.

Instructions Output format Article abstract


Paste a single sequence or several sequences in FASTA format into the field below:

Submit a file in FASTA format directly from your local disk:

Generate graphics   

At most 2000 sequences and 200,000 amino acids per submission; each sequence not less than 15 and not more than 6,000 amino acids. Different sequence names are required.

The sequences are kept confidential and will be deleted after processing.


For publication of results, please cite:

Analysis and prediction of leucine-rich nuclear export signals
Tanja la Cour, Lars Kiemer, Anne Mølgaard, Ramneek Gupta, Karen Skriver and Søren Brunak
Protein Eng. Des. Sel., 17(6):527-36, 2004.

Download the paper.
Download the supplementary information.

View the abstract.


Would you prefer to run NetNES at your own site?
NetNES 1.1 is available as a package on a commercial license. Currently available platforms include MIPS (under IRIX, Silicon Graphics), SPARC (under Solaris, Sun), Alpha (under OSF1) and Pentium family (under Linux and CYGWIN).
Send inquiries by e-mail to


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