NetTepi 1.0 Server
NetTepi 1.0 predicts Tcell epitopes from protein sequences. The method integrates
three prediction types, peptideMHC binding affinity, peptideMHC stability and
Tcell propensity.
The server allows for predictions of Tcell epitopes restricted
to 13 different Human MHC (HLA) alleles representing 11 of the 12 common HLAA and
B Supertypes as defined by Lund et al (2004).
Predictions of lengths 814: Predictions can be made for lengths between
8 and 14 for all alleles using an approximation algorithm. Note that only lengths
9 and 10 have been thoroughly benchmarked. Caution should be taken with predictions
for all other lengths.
Prediction values are calculated as a weighted sum of binding affinity, stability
and Tcell propensity prediction scores. A % Rank score based on predictions for
200.000 random natural peptides is also provided.
PeptideMHC binding affinity predictions are obtained using the
NetMHCcons method.
PeptideMHC stability predictions are obtained using the
NetMHCstab method.
Tcell propensity is predicted using the immunogenicity model described by
Calis et al (2013).
Note as of 5 dec 2016 the server has been updated to make affinity
predictions using NetMHCcons1.1. Old functionality can be recovered following
the link Earlier functionality.
CITATIONS
For publication of results, please cite:
NetTepi: an integrated method for the prediction of T cell epitopes.
Trolle T, Nielsen M. Immunogenetics (2014). 66(78):44956.
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