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PGx pipeline 1.0 Server

The PGx pipeline 1.0 server can be used to prioritize pharmacogene candidates. By comparing an input drug (or a set of input drugs) and its (their) putative indications with a repository of known gene-drug interactions, the PGx pipeline ranks the entire genome for their likelyhood of being involved in the pharmacogenetic response to the inputted drug(s). As the method utilizes protein-protein interactions to infer pharmacogenetic function of genes, the method is both capable of recalling new gene-drug interactions and predicting entirely novel pharmacogenes.

NOTE: The method integrates several large datasets in each run, so expect 2-3 minutes delay when running the pipeline.

The JME applet (Java Molecular Editor) used below has been provided by courtesy of dr Peter Ertl.

Instructions Output format Article abstract

SUBMISSION

Paste or import molecules in SMILES-format:
Construct a molecule:
Enable Java in your browser ! When done ...

Submit a file in SMILES format directly from your local disk:

Submit a file in SDF format directly from your local disk:

Select indications (at least one, use CTRL - LEFT_CLICK to select multiple indications)

Select treshold Max number of genes

Confidentiality:
The compounds are kept confidential and will be deleted after processing.

CITATIONS

For publication of results, please cite:

Generating Genome-Scale Candidate Gene Lists for Pharmacogenomics.
Hansen N, Brunak S, Altman R.
Clin Pharmacol Ther. Apr 15, 2009. [Epub ahead of print]

View the abstract.

GETTING HELP

Scientific problems: Technical problems:

This file was last modified Monday 4th of May 2009 11:05:22 GMT