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ProP 1.0 Server

ProP 1.0 server predicts arginine and lysine propeptide cleavage sites in eukaryotic protein sequences using an ensemble of neural networks. Furin-specific prediction is the default. It is also possible to perform a general proprotein convertase (PC) prediction.

For convenience, this server is integrated with the SignalP server predicting the presence and location of signal peptide cleavage sites.

Instructions Output format Article abstract


Paste a single sequence or several sequences in FASTA format into the field below:

Submit a file in FASTA format directly from your local disk:
Generate graphics Include signal peptide prediction
Verbose output General PC prediction

At most 2000 sequences and 200,000 amino acids per submission; each sequence not more than 4,000 amino acids.

The sequences are kept confidential and will be deleted after processing.


For publication of results, please cite:

Prediction of proprotein convertase cleavage sites.
Peter Duckert, Søren Brunak and Nikolaj Blom.
Protein Engineering, Design and Selection: 17: 107-112, 2004.

View the abstract.


Would you prefer to run ProP at your own site? ProP 1.0 is available as a stand-alone software package, with the same functionality as the service above. Ready-to-ship packages exist for the most common UNIX platforms. There is a download page for academic users; other users are requested to contact CBS Software Package Manager at


Scientific problems:        Technical problems: