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SignalP V1.1
World Wide Web Prediction Server
Center for Biological Sequence Analysis
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Please note that this is an old version of SignalP.
The current version can be found at:
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The SignalP World Wide Web server
predicts the presence and location of signal peptide cleavage sites in
amino acid sequences from different organisms: Gram-positive
prokaryotes, Gram-negative prokaryotes, and eukaryotes. The method
incorporates a prediction of cleavage sites and a signal
peptide/non-signal peptide prediction based on a combination of several
artificial neural networks.
Nobel Prize for Signal
Peptides: The 1999 Nobel Prize in Physiology or Medicine
has been awarded to Günter Blobel for the discovery that
"proteins have intrinsic signals that govern their transport and
localization in the cell." The first such signal to be
discovered was the secretory signal peptide, which is the signal
predicted by SignalP. Read the press
release.
SignalP is being updated to version
2.0, incorporating both neural network-based and hidden Markov
model-based predictions. To try a beta version of SignalP V2.0,
click here!
Usage
The method is described in
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Identification of prokaryotic and eukaryotic signal peptides and prediction
of their cleavage sites.
Henrik Nielsen, Jacob Engelbrecht, Søren Brunak and Gunnar von
Heijne,
Protein Engineering 10, 1-6 (1997).
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Protein Engineering has made the full-text PDF version of this
paper freely available online at the
Red Hot Research Page.
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Review. Machine learning approaches to the prediction of
signal peptides and other protein sorting signals.
Henrik Nielsen, Søren Brunak, and Gunnar von Heijne,
Protein Engineering 12, 3-9 (1999).
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Abstract
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A neural network method for identification of prokaryotic and
eukaryotic signal peptides and prediction of their cleavage sites.
Henrik Nielsen, Jacob Engelbrecht, Søren Brunak and Gunnar von
Heijne,
Int. J. Neural Sys. 8, 581-599 (1997).
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Abstract
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From sequence to sorting: Prediction of signal peptides.
Henrik Nielsen, Ph.D. thesis. Defended at Department of Biochemistry,
Stockholm University, Sweden, May 25 1999.
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Abstract
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Hot Paper in BIOINFORMATICS - an interview by Eugene Russo
with SignalP author Henrik Nielsen.
The Scientist
Volume 13, #13, p. 8, June 21, 1999.
Further information
Background
Signal peptide data set
Methods
Results
Mail server
If your browser does not support forms, or if you want to submit more than
one sequence at a time, you may use the
instead of the WWW submission form.
Portable version
Would you prefer to run SignalP at your own site? SignalP 1.2 is
available as a package on a commercial license. Currently available
platforms include
MIPS (under IRIX, Silicon Graphics),
SPARC (under Solaris, Sun) and
Alpha (under OSF1). Send inquiries by e-mail to
software@cbs.dtu.dk.
Please note that this is an old version of SignalP.
The current version can be found at:
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COMMENTS AND SUGGESTIONS
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PROBLEMS
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Last change: Feb 14, 2001,
Kristoffer Rapacki
