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SignalP V1.1World Wide Web Prediction ServerCenter for Biological Sequence Analysis |
The position vs. count matrices are given here as a comparison to those published by von Heijne in 1986 (Nucleic Acids Res., 14, 4683-4690). The range of positions is the same: -13 to +2 relative to the cleavage site.
The position vs. count matrices are easily converted to weight matrices of the type used by von Heijne:
where a denotes amino acid and p denotes position. The
expected number, 
, is the average frequency
of each amino acid times N, the number of cleavage sites in the
sample. The average frequencies in these tables are calculated from
the actual signal peptide data (we found this to yield a better
cleavage site location performance than using standard distributions).
-13 -12 -11 -10 -9 -8 -7 -6 -5 -4 -3 -2 -1 1 2 exp. A 101 112 106 100 158 128 107 149 146 107 258 80 458 141 55 73.86 C 36 32 34 31 42 66 57 39 30 34 68 21 50 23 27 27.14 D 2 0 3 0 3 2 4 5 25 14 4 44 6 68 66 28.42 E 1 2 4 5 4 6 13 9 28 27 7 66 6 92 88 36.57 F 75 67 80 81 65 58 92 67 25 34 7 46 6 34 28 33.80 G 39 24 26 34 36 50 40 29 108 125 74 38 184 52 57 53.42 H 5 3 4 2 4 10 14 7 23 12 5 53 2 23 22 14.76 I 73 67 82 59 52 52 47 69 22 43 41 18 4 37 34 33.45 K 4 1 1 2 0 3 3 3 20 19 7 24 4 52 40 31.95 L 376 432 397 449 386 329 333 280 98 147 65 165 21 60 51 116.43 M 26 15 21 19 11 30 20 11 5 12 9 14 3 14 12 27.84 N 2 4 4 6 7 7 8 7 25 14 9 37 9 26 53 26.56 P 23 13 17 9 12 13 24 60 98 74 7 17 27 11 166 44.53 Q 3 6 4 9 11 19 18 13 55 40 5 72 15 135 42 30.72 R 7 4 4 2 3 7 9 6 34 38 5 56 20 33 40 34.01 S 57 47 40 44 65 76 67 66 117 97 142 112 141 91 88 65.26 T 32 39 30 38 38 49 42 35 70 70 103 44 43 39 57 45.02 V 112 124 127 100 99 86 79 129 60 72 191 45 8 50 56 56.25 W 16 13 20 11 9 13 24 21 13 13 2 33 2 9 6 12.12 Y 17 3 6 9 6 7 10 6 8 19 2 26 2 21 23 18.49
-13 -12 -11 -10 -9 -8 -7 -6 -5 -4 -3 -2 -1 1 2 exp. A 63 58 56 64 63 39 41 78 34 41 156 20 229 102 19 31.56 C 10 6 5 5 6 5 4 7 3 0 3 3 0 4 0 2.94 D 0 1 1 2 1 2 2 0 0 1 2 2 0 17 43 8.01 E 0 0 0 1 1 0 1 0 1 2 1 4 1 21 40 7.30 F 15 12 18 12 17 32 31 7 17 13 1 28 0 2 1 8.49 G 20 22 17 13 11 29 19 13 41 15 5 5 11 12 15 14.73 H 1 0 0 0 1 0 2 1 7 1 1 32 0 2 0 3.01 I 17 22 16 15 16 5 25 11 4 9 3 5 0 3 9 10.72 K 0 1 2 0 0 0 1 0 1 4 1 3 0 12 4 12.13 L 60 61 71 63 67 82 44 7 31 12 15 42 4 8 11 21.30 M 11 9 9 8 17 12 17 9 4 2 0 19 0 3 2 8.24 N 2 1 2 2 3 0 2 5 5 13 2 15 3 10 13 8.80 P 2 4 6 6 5 3 4 19 16 40 1 0 1 1 23 8.36 Q 0 0 0 2 2 1 0 1 13 12 3 25 0 30 15 7.80 R 3 2 1 1 2 3 2 0 6 5 3 4 1 3 2 7.58 S 16 21 19 30 20 17 29 72 39 53 25 18 11 12 16 16.94 T 15 11 20 17 13 15 18 23 26 19 10 13 3 6 32 14.95 V 28 32 21 21 16 18 18 11 16 14 33 14 2 12 17 15.67 W 0 0 1 1 1 1 2 1 1 0 0 5 0 1 3 2.32 Y 1 1 0 2 3 2 4 1 0 10 1 9 0 5 1 4.32
-13 -12 -11 -10 -9 -8 -7 -6 -5 -4 -3 -2 -1 1 2 exp. A 29 27 17 32 25 17 19 27 14 13 77 18 114 58 15 15.39 C 2 2 2 1 1 1 1 0 0 0 0 1 0 0 0 0.77 D 0 1 1 0 1 0 0 4 3 7 1 3 0 15 13 4.23 E 2 0 1 1 1 1 1 3 4 3 5 11 2 13 15 3.95 F 8 8 6 11 14 5 12 1 1 3 2 10 0 2 0 4.27 G 6 13 14 14 12 17 12 9 16 7 4 11 5 1 10 7.70 H 0 0 0 0 1 0 2 3 1 2 1 8 0 1 4 1.29 I 10 10 14 10 7 8 6 8 2 5 4 2 0 3 4 5.67 K 1 0 1 0 0 0 0 2 6 7 0 12 2 8 4 7.60 L 26 31 26 27 31 32 18 10 5 5 3 5 0 1 1 11.26 M 3 5 4 3 2 7 3 3 0 5 0 1 0 0 0 4.08 N 1 1 0 1 5 2 7 3 13 9 1 6 1 6 5 5.40 P 3 3 5 3 9 6 16 22 20 15 1 2 0 2 16 5.11 Q 0 3 0 0 0 4 7 5 8 5 0 17 1 8 6 3.64 R 1 0 0 2 0 1 0 1 1 3 2 1 3 1 1 4.28 S 14 11 17 13 13 14 12 11 18 13 12 19 8 14 17 9.76 T 17 13 14 7 7 12 9 16 19 28 1 4 1 4 21 9.51 V 18 12 18 15 11 10 14 12 10 9 27 3 3 2 8 8.70 W 0 0 0 1 1 2 1 0 0 0 0 2 0 1 0 1.12 Y 0 1 1 0 0 2 1 1 0 2 0 5 1 1 1 2.80
