SignalP-5.0 Server

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DeepLoc Remember, the presence or absence of a signal peptide is not the whole story about the localization of a protein! If you want to find out more about the sorting of your eukaryotic proteins, try the protein subcellular localization predictor.

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The SignalP 5.0 server predicts the presence of signal peptides and the location of their cleavage sites in proteins from Archaea, Gram-positive Bacteria, Gram-negative Bacteria and Eukarya. In Bacteria and Archaea, SignalP 5.0 can discriminate between three types of signal peptides:

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep)
Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp)
Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep)

SignalP 5.0 is based on a deep convolutional and recurrent neural network architecture including a conditional random field.

Protein sequences should be not less than 10 amino acids. The maximum number of proteins is 5000.

Organism group:
Eukarya
Gram-positive
Gram-negative
Archaea

Output format:
Long output
Short output (no figures)

Example proteins

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