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SigniSite 1.0 Server

SigniSite 1.0 estimates the significance of the distribution of residues for each site of a given alignment and visualizes the results using a heatmap and sequence logos.

The sequences in the alignment are assumed to be sorted with respect to some value associated with them, e.g. enzyme activity or binding affinity. A Z score is calculated for each residue type at each position of the alignment.

Instructions Output format Article abstract

SUBMISSION

Paste a multiple alignment in FASTA format into the field below:

Submit a multiple alignment file in FASTA format directly from your local disk:

Significance threshold Show only significant sites Show only significant residues in the logo output

Correct for multiple testing using:

Consider values given in the Fasta header
By default the values are sorted in increasing order. Choose decreasing order

You may choose a sequence relative to which the positions in the output are numbered.
By default, the numbering reflects the position in the multiple sequence alignment.
Enter the sequence identifier of the sequence relative to which the positions should be numbered:

Confidentiality:
The sequences are kept confidential and will be deleted after processing.

PORTABLE VERSION

Would you prefer to run SigniSite at your own site? SigniSite 1.0 software package is in preparation. Available platforms will include MIPS (under IRIX, Silicon Graphics), SPARC (under Solaris, Sun) and Pentium family (under Linux). Send inquiries by e-mail to software@cbs.dtu.dk.

GETTING HELP

Scientific problems: Technical problems:

This file was last modified Monday 27th of April 2009 10:53:08 GMT