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TatP 1.0 Server

TatP 1.0 server predicts the presence and location of Twin-arginine signal peptide cleavage sites in bacteria. The method incorporates a prediction of cleavage sites and a signal peptide/non-signal peptide prediction based on a combination of two artificial neural networks. A postfiltering of the output based on regular expressions is possible.

View the version history of this server. All the previous versions are available on line, for comparison and reference.

Background Article abstracts Instructions Output format


Paste a single sequence or several sequences in FASTA format into the field below:

Enter a regular expression (Instructions):

Submit a file in FASTA format directly from your local disk:

No graphics
GIF (inline)
GIF (inline) and EPS (as links)

Output format
Short (no graphics!)

Truncate each sequence to max. residues.

We recommend that only the N-terminal part of each protein sequence is submitted.
Enter 0 (zero) to disable truncation.

At most 4,000 sequences and 2,000,000 amino acids per submission; each sequence not more than 5,000 amino acids.

The sequences are kept confidential and will be deleted after processing.


For publication of results, please cite:

  • Current version:

    Prediction of twin-arginine signal peptides.
    Jannick Dyrløv Bendtsen, Henrik Nielsen, David Widdick, Tracy Palmer and Søren Brunak.
    BMC bioinformatics 2005 6: 167.

    View the abstract.


Would you prefer to run TatP at your own site? TatP 1.0 is available as a stand-alone software package, with the same functionality as the service above. Ready-to-ship packages exist for Linux and IRIX64. There is a download page for academic users; other users are requested to contact CBS Software Package Manager at


Scientific problems:        Technical problems: