from Nature Magazine
from the American Scientist
from the New Scientist
Brief review from Scientific American
Reports of the National Center for Science Education:
The Elusive Scientific Basis of Intelligent Design Theory
American Spectator (Sept., 1996)
TheWall Street Journal
The Boston Review
H.Allen Orr's review of Darwin's Black Box
A Delicate Balance
Miracles and Molecules
More Crank Science
"Enough Speculation", by Michael Ruse
"The Sterility of Darwinism" by Michael J. Behe
Magazine Vol . 4 No. 3 1996
by Peter Atkins, University of Oxford
A reducibly complex
A Rebuttal of Behe
the "Intelligent Designer" argument a Scientific One?
Real Scoop on Michael Behe...
...and why creationism is still a bad idea.
The Talk.Origins Archive:
Publish or Perish - Some Published works on Biochemical Evolution
Behe and the Blood Clotting Cascade
Irreducible Complexity and Michael Behe
Complexity--Yes! Irreducible--Maybe! Unexplainable--No! A Creationist Criticism of Irreducible Complexity
A Review from the Center for Renewal of Science and Culture
Michael Behe shows
why Phillip Johnson is wrong in claiming that Darwin created a nonfalsifiable
version 2.2a by Gert Korthof
Darwin's Black Box: A Brief Review- by Norman L. Geisler, President of Southern Evangelical Seminary
The Cydonia Update - March, 1997
DARWIN'S BLACK BOX
Meeting Darwin's Wager
ORIGINS review by Phillip Johnson
Alumni Bulletin -- Darwin's Black Box
BOOKS REVIEW PAGES VOL 2 NO 4 - APRIL 98
comments by Richard Dawkins, concerning Michael Behe
Richard Dawkins on Evolution and Religion
When Religion Steps on Science's Turf The Alleged Separation Between the Two Is Not So Tidy - by Richard Dawkins
Ross's Web Site
Access Research Network's
page for Michael Behe
(this has lots of good links - including to Behe's published articles)
Behe's (NEW) Home page
Michael J. Behe, Ph.D.
About my research...
DNA was long regarded as a functionally inert molecule-a
long punchtape that was acted upon by proteins, which did the really interesting
work. The discovery of Z DNA in the late 1970s changed the way in which
we perceive polydeoxynucleotides. Now it is realized that these polymers
can act, as well as be acted upon. Further research into DNA structure
showed a wealth of alternative conformations available to selected sequences:
left hand helical structures, hairpins, triple and quadruple strands. There
is, however, a problem in assessing the significance of the alternative
forms: most of them were first seen, and have been subsequently studied,
in synthetic molecules. Thus the danger is that, although physically interesting,
they were physiologically irrelevant. The task of proving their relevance
in vivo has been daunting, since candidate sequences could flip back and
forth between the B form and alternative forms. Since the large scale sequencing
projects have begun, another way to gauge the relevance of alternative
conformations is available: check genomic sequences for the accumulation
or repression of sequences required for an alternative form. The overabundance
of a sequence template that is known to be able to exist in a non-B form
is strong a priori evidence that the conformation in fact has a role to
play in the cell. In the past year and a half an enormous increase in the
sequence database has enabled us to scan tens of millions of nucleotides
from a number of eukaryotes. This work has produced several striking results,
and enabled us to focus our attention on those nonstandard conformations
which appear to actually be used in organisms. The most obvious candidates,
and the ones we focus our attention on, are the oligoadenosine and oligoguanosine
tracts that are very strongly overrepresented in human and C. elegans DNA,
respectively. Despite early reports that oligoadenosine tracts could not
accommodate nucleosomes, our laboratory has shown that, not only can such
tracts be accommodated (1), but that at higher temperatures (and probably
under other conditions which would disrupt the spine of hydration in oligoadenosine
tracts) nucleosomes bind the tracts more strongly than other sequences
(2,3). Therefore we hypothesize that such tracts can be used as phasing
elements. To test this hypothesis we are constructing plasmids containing
multiple adenosine tracts spaced by distances up to a thousand base pairs,
and examining the phasing of reconstituted nucleosomes on the plasmid DNA
compared to DNA without such tracts. Oligoguanosine tracts have been shown
to have the startling ability to form quadruplex polynucleotide structures
and polyguanosine has been known for decades to associate to form very
strong, multistranded complexes. In general, oligoguanosine tracts are
rare in eukaryotes; most eukaryotic DNA sequenced so far is AT-rich, and
guanosine tracts longer than 10 in a row are found infrequently. However,
our recent search (4) has shown that such tracts are startlingly common
in C. elegans. We hypothesize that the tracts are being used as structural
elements, and are looking for evidence that bears on this. The association
of oligoguanosine tracts in plasmid DNA is being examined as a function
of supercoiling density. Additionally, a search is being conducted for
proteins from C. elegans that bind specifically to oligoguanosine tracts.
Created on Thu Jul 28 10:44:26 EDT 1994 by Lehigh's Web Server.
To contact me, send e- mail to mjb1@Lehigh.EDU.
Department of Biological Sciences
Iacocca Hall, Building 111
Bethlehem, PA 18015
To return to Lehigh's home page, click here.
Lehigh's Biological Sciences Department.
Michael J. Behe
Associate Professor of
Department of Biological
Michael Behe Schedule
Book: Darwin's Black Box
Audio Tape: Intro. to DBB
Behe Responds to Critics
December 19, 1997 Firing Line Debate Articles
Sunday Morning -- Michael Behe
Posted by Stephen B. Coulson on June 23, 1997 at 01:17:39:
What a shame Michael Behe was given a forum to espouse his views on
subject which is not his field of study without the benefit of refutation
by someone who actually knows better.
Under the Microscope
By Michael J. Behe
Michael J. Behe, associate professor of biochemistry at Lehigh University, is the author of "Darwin's Black Box: The Biochemical Challenge to Evolution."
The Cydonia Update - March,
In the 1980s, Dr. Michael Denton, an microbiological researcher, wrote
ground-breaking book, Evolution: A Theory in Crisis. In one prominent passage, he
wrote of what a living cell would look like if it were expanded to the size of a city:
. . . We would see all around us, in every
direction we looked, all sorts of
robot-like machines. We would notice that the simplest of the functional
components of the cell, the protein molecules, were astonishingly complex
pieces of molecular machinery, each one consisting of about three thousand
atoms arranged in highly organized 3-D spatial conformation. We would
wonder even more as we watched the strangely purposeful activities of these
weird molecular machines.
Wonder no more, because Denton's molecular biological critique of evolution
joined by Michael Behe, a biochemist whose Darwin's Black Box: The Biochemical
Challenge to Evolution finishes the intellectual decapitation of the evolutionary
crusade. Darwin himself, Behe contends, threw down the gauntlet when he wrote
If it could be demonstrated that any complex
organ existed which could
not possibly have been formed by numerous, successive, slight
modifications, my theory would absolutely break down.
And so Behe introduces the concept of 'irreducible complexity.'.....
Under the Covers: Darwin's Black Box by Behe
DARWIN'S BLACK BOX: THE BIOCHEMICAL CHALLENGE TO EVOLUTION
by Michael Behe
Free Press 8/96; $25.00 hardcover; ISBN 0684827549
Several of the books I have recommended on the subject of evolution(ism)
past have been hard to get hold of; Michael Behe's "Darwin's Black Box" is
available at Borders. Likewise, evolutionists on the net have claimed that Phillip
Johnson and Alexander MeBane lack proper "credentials" to write on
evolution(ism); Behe is a professor of biochemistry at Lehigh University.
Darwin's Black Box
Michael Behe shows why Phillip Johnson is wrong in claiming that Darwin created a nonfalsifiable theory !
Reviews & comments on "Darwin's Black Box" by Robert Shapiro and Peter van Inwagen.
Virtually all serious scientists accept the truth of Darwin's theory
evolution. While the fight for its acceptance has been a long and difficult one,
after a century of struggle among the cognoscenti the battle is over....
These bookmarks are given in no particular order except that I consider the earlier ones more useful than the later ones. Organizations to which I belong are highlighted.
Michael J. Behe, associate professor of biochemistry at Lehigh University,is the author of "Darwin's Black Box: The Biochemical Challenge to Evolution."
The Evolution of a Skeptic
An Interview with Dr. Michael Behe, biochemist and author of recent best-seller, Darwin's Black Box
by Michael J. Behe
Hardcover The Free Press, ISBN 0684827549
Read more about Michael J. Behe
Biochemists have discovered chemical machines of such intricate beauty and stunning complexity that they cannot have evolved by chance.
Scientists finally have been able to unlock the secrets of the
cell, where they
have found complex machines with finely calibrated, interdependent parts. How
can these machines have evolved through random mutation?...
This Month's Episodes:
Resolved: The Evolutionists Should Acknowledge Creation
F. Buckley Jr. heads the panel arguing for the
resolution with Phillip E. Johnson, professor of law at the
University of California; Michael Behe, professor at Lehigh
University; and author David Berlinski. Arguing against the
resolution are Barry Lynn, executive director of Americans
United for Separation of Church and State; Eugenie Scott,
executive director of the National Center for Science
Education; Michael Ruse, professor at the University of
Guelph in Ontario, Canada; and Kenneth Miller, professor
of biology at Brown University.