ABSTRACT
A
DNA STRUCTURAL ATLAS of E. coli
D.W. Ussery
(CBS, Technical University, Denmark)
A.G.Pedersen(CBS,
Technical University, Denmark)
Alex Bolshoy,
(NIH/NLM/NCBI, Bethesda, MD, USA)
Hans Henrik
Stærfeldt(CBS, Technical University, Denmark)
Søren
Brunak (CBS, Technical University, Denmark)
The
complete nucleotide sequence for the Escherichia coli genome was
examined, using a set of 5 different DNA structural parameters: base-stacking
interactions, intrinsic DNA curvature, DNA flexibility, rigidity (propeller
twist), and complexity. We have found preferential localisation of
sequences prone towards unique structures within intergenic regions.
Furthermore, there are certain areas of the genome which might serve as
centers for chromatin organisation, based on the presence of regions of
unusual DNA motifs. A comparison of these global structural
features
with other bacterial genomes is also presented.
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