30431 Introduktion til Bioinformatik
 
Introduction to Bioinformatics
DNA Structures and Information
David Ussery
Tuesday, 8 September, 1998
 
 
 

 

 

 
 
  II. Biological Sequences as Information
DNADNA sequence as information

The DNA sequence contains several different types of information:

1. The DNA sequence can code for an amino acid sequence for proteins

2. The DNA sequence can code for an RNA sequence

  • tRNA
  • rRNA
  • snRNA
  • telomeraseRNA
  • other RNAs
  • 3. The DNA sequence can code for protein binding sites
     
     
    4. The DNA can code for architectural information
  • intrinsic DNA curvature
  • nucleosome positioning
  • 5. The DNA can code for structural / stability information
  • transcription initiation
  • origins of replication
  • mutational "hot spots"
  •  
     

     
     
    RNARNA sequence as information

    The RNA sequence also contains several different types of information:

    1. The mRNAs can contain several different levels of information:
  • specifies amino acid sequence for proteins
  • localisation signals for WHERE the protein will be made
  • stability signals to determine HOW MUCH protein is made
  • splice sites
  • editing sites
  • 2. The tRNAs code for the genetic code - same in all living organisms (n.b. diff. in mitochondria)
     
     
    4. The rRNAs code for the structures of ribosomes
  • intrinsic DNA curvature
  • nucleosome positioning
  • 5. Other RNA/protein complexes have important biological functions
  • RNA template for teleomerase enzyme - necessary to prevent cancer
  • snRNAs necessary for mRNA splicing
  • snoRNAs are small nucleolar RNAs.
  •  

     
     
    Protein sequence as information

    The PROTEIN sequence contains several different types of information:

    1. The protein sequence can code for an "active site" for enzymes

    2. The protein sequence can code for structural roles:

  • microtubules
  • myosin
  • collagen
  • etc.
  • 3. The protein sequence can code for ion channels/pumps
     
     
    4. The protein sequence can code for localisation information
  • within the cell
  • extra-cytoplasmic
  • 5. The protein sequence can code for modification sites
     
     
     leaf bar
     

     
    LINKS:
     
    Back to today's lecture outline
     

    Back to the course syllabus
     

    Back to Dave's Homepage


    Back to the CBS Homepage  CBS home page
     
     
     

    980903 du