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DTU course #27104 The Scientific Communication of Comparative Genomics

Course Programme - Autumn 2011
Link to description of course in DTU course catalogue


The course meets on Wednesday mornings (kl. 8.30-12) and Thursday afternoons, (kl. 13-17), and will start on Wednesday, 31 August, 2011 at 08:30. Lectures, journal clubs and exercises will take place in lecture hall 060 (downstairs) in building 208, at the Technical University of Denmark, Lyngby.

Performance will be evaluated as described on the course overview page. Briefly, the grade is determined by a journal club report (25%), a poster (25%), and a final written manuscript (50%). The aims and learning objectives for this course are as described on the course webpage and also in the DTU course catalog.


Link to DNA Atlas pages       List of Prokaryotic Genomes at NCBI     

overview





O Wednesday, 31 August, 2011     Introduction to bioinformatics and databases


8.30-9.15
Chapter 1 from textbook - "Sequences as Biological Information: Cells Obey the Laws of Chemistry and Physics"
Link to pdf file of lecture notes
9.15-9.30
Break
9.30-10.15
Chapter 2 from textbook - "Introduction to Bioinformatics"
Link to pdf file of lecture notes
10.15-10.30
Break
10.30-11.30
Journal Clubs and Posters - a brief overview
Link to pdf file of genomes list
Initial sign-up for teams of four students for computer exercises and papers
Literature: Chapters 1 (16 pages) and 2 (18 pages) in the textbook       Signature in the Cell book review




O Thursday, 1 September, 2011      



13.00-13.30
Discussion of projects and groups of genomes for computer exercises and reports
Link to pdf file of genomes list
Link to pdf file of Tammi's talk
13.30-13.45
Break
13.45-14.30
Chapter 3 from textbook - "Comparative Microbial Genomics: A Brief Overview"
Link to pdf file of lecture notes
14.30-14.45
Break
14.45-15.30
Chapter 4 from textbook - "Genomic Databases"
Link to pdf file of lecture notes
15.30-15.45
Break
15.45-16.30
Discussion about what is expected
Literature: Chapters 3 (14 pages) and 4 (12 pages) in the textbook
Ten Simple Rules for Getting Published





O Wednesday, 7 September, 2011       Introduction to Unix and CMG biotools, downloading genomes


8.30-9.15
Lecture by Matloob Qureshi - Chapter 5 from textbook - "The Challenges of Programming"
9.15-9.30
Break
9.30-10.00
"Unix How-to lecture" by Matloob Qureshi
10.00-12.00
Introduction to groups for the course:
Literature: Chapter 5 of the textbook (21 pages).       Unix-How-To Guide       Bacterial Genome Groups for Journal Club, Posters, and Papers

overview





O Thursday, 8 September, 2011


13.00-13.45
Chapter 6 from textbook - "Comparing Genomes - Bacterial Genomics"
Link to pdf file of lecture notes (final version)
13.45-14.00
Break
14.00-14.30
Example Journal Club - "Defining the Pseudomonas Genus"
Link to pdf file of presentation slides
14.30-16.30
Computer exercises - Week 1. Link to pdf file of lecture notes
Literature: Chapter 6 (9 pages) in the textbook       Link to Pseudomonas Journal Club article       Link to PubMed
overview





O Wednesday, 14 September, 2011       Gene Finding & Basic Genome Statistics


8.30-9.15
Chapters 7, 8 from textbook - "Genomic Properties"
Link to pdf file of lecture notes (final version)
9.15-9.30
Break
9.30-10.00
Journal Club # 1 - Acinetobacter - Linda, Monica, Malene, Isa
Link to pdf file of journal club
10.00-10.15
Break
10.15-10.45
Journal Club # 2 - Lactobacillus - Linda, Dilek, Catharina
Link to pdf file of journal club
10.45-12.00
Computer exercises - Week 2, day 1.

other files - updated 14 September, 2011... GeneWiz executable      GenomeAtlas configuration file generator script      NEW genomeatlas shell script (to replace the old one!)     


Literature: Chapter 7 (21 pages) and Chapter 8 (11 pages) in the textbook,       Link to Acinetobacter (Journal Club # 1) article,       Link to Lactobacillus (Journal Club # 2) article.




O Thursday, 15 September, 2011

13.00-13.45
Chapter 9 from textbook - "Transcriptomics"
Link to pdf file of lecture notes
13.45-14.00
Break
14.00-14.30
Journal Club # 3 - Salmonella - Martin, Tanni, Sandra, Sebastian, Julie
Link to pdf file of journal club
14.30-14.45
Break
14.45-15.15
Journal Club # 4 - Bifidobacterium - Stine, Dan, Lene, Sufia
Link to pdf file of journal club
15.15-17.00
Computer exercises - Week 2, day 2.
Literature: Chapter 9 (12 pages) in the textbook,       Link to Salmonella (Journal Club # 3) article ,       Link to Bifidobacterium (Journal Club # 4) article.
overview





O Wednesday, 21 September, 2011 - Ribosomal sequence analysis, basic phylogenetics


8.30-9:30
Computer exercises - Week 3, day 1.
PDF of presentation (overview of computer exercises for Week 3)
9.30-10.15
Chapter 13 from textbook - "Metagenomics" - special guest lecture by Professor Francisco Rodriguez-Valera, Universidad Miguel Hernandez, San Juan de Alicante, Spain
Link to pdf file of lecture notes
10.15-10.30
Break
10.30-11.00
Journal Club # 5 - Brucella - Ola, Una, Michael, Maja
Link to pdf file of journal club
11.00-11.15
Break
11.15-11.45
Journal Club # 6 - Escherichia - Yongguang, Katarzyna, Jing, Boryana
Link to pdf file of journal club
Literature: Chapters 13 (14 pages) in the textbook,       Link to Brucella (Journal Club # 5) article ,       Link to Escherichia (Journal Club # 6) article .




O Thursday, 22 September, 2011



13.00-13.45
Chapter 10 from textbook - "Expression of Genes and Proteins"
Link to pdf file of lecture notes
13.45-14.00
Break
14.00-14.30
Chapter 11 from textbook - "Of Proteins, Genomes, and Proteomes"
Link to pdf file of lecture notes
14.30-14.45
Break
14.45-15.15
Journal Club # 7 - Vibrio - Iliana, Susan, Kasper, Dominika
Link to pdf file of journal club
15.15-15.30
Break
15.30-16.00
Journal Club # 8 - Staphylococcus - Henrik, Marc, Athansios, Rasmus, Marwa
Link to pdf file of journal club
16.00-17.00
Computer exercises - Week 3, day 2.
Literature: Chapters 10 (19 pages) and 11 (15 pages) in the textbook,       Link to Vibrio (Journal Club # 7) article ,       Link to Staphylococcus (Journal Club # 8) article .

overview





O Wednesday, 28 September, 2011 - Proteome comparisons



8.00-8.45
Chapter 12 from textbook - "Microbial Communities"
Link to pdf file of lecture notes
8.45-9.00
Break
9.00-9.45
Chapter 14 from textbook
Link to pdf file of lecture notes
9.45-10.00
Break
10.00-10.30
Journal Club # 9 - Bacillus - Tine, Martin, Niels, Sabine
Link to pdf file of journal club
10.30-12.00
Computer exercises.
Literature: Chapters 12 and 14 of the textbook,       Link to Bacillus (Journal Club # 9) article




O Thursday, 29 September, 2011



13.00-17.00
Computer exercises.





O Wednesday, 5 October, 2011 Work on Posters


10.00-10:30
Lecture on posters - some tips of what to include, and what makes a good poster
Link to page for zoomable atlases         Link to PDF of zoomable atlas paper describing method

O Thursday, 6 October, 2011 Work on Posters






O Wednesday, 12 October, 2011 Work on Posters



O Thursday, 13 October, 2011 Work on Posters










O Wednesday and Thursday, 19-20 October, 2011

Autumn Break














O Wednesday, 26 October, 2011 - Submit poster



O Thursday, 27 October, 2011 - POSTER party! Work on Papers










O Wednesday, 2 November, 2011 Work on Papers



O Thursday, 3 November, 2011 Work on Papers










O Wednesday, 9 November, 2011 Work on Papers



O Thursday, 10 November, 2011 Work on Papers


13.00-14.00
Lecture on What is Expected for the final paper
link to pdf of lecture notes.








O Wednesday, 16 November, 2011 Work on Papers



O Thursday, 17 November, 2011 - Hand in papers for Critique in class


overview








O Wednesday, 23 November, 2011 Revise papers (if necessary)



O Thursday, 24 November, 2011 WRevise papers (if necessary)






O Thursday, 1 December, 2011 - FINAL PAPERS due







Course organiser: David W. Ussery