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The course meets on Wednesday mornings (kl. 8.30-12) and Thursday afternoons, (kl. 13-17), and will start on Wednesday, 31 August, 2011 at 08:30. Lectures, journal clubs and exercises will take place in lecture hall 060 (downstairs) in building 208, at the Technical University of Denmark, Lyngby.
Performance will be evaluated as described on the course overview page. Briefly, the grade is determined by a journal club report (25%), a poster (25%), and a final written manuscript (50%). The aims and learning objectives for this course are as described on the course webpage and also in the DTU course catalog.
Link to DNA Atlas pages
List of Prokaryotic Genomes at NCBI

Wednesday, 31 August, 2011 Introduction to bioinformatics and databases
- 8.30-9.15
- Chapter 1 from textbook - "Sequences as Biological Information: Cells Obey the Laws of Chemistry and Physics"
Link to pdf file of lecture notes
- 9.15-9.30
- Break
- 9.30-10.15
- Chapter 2 from textbook - "Introduction to Bioinformatics"
Link to pdf file of lecture notes
- 10.15-10.30
- Break
- 10.30-11.30
- Journal Clubs and Posters - a brief overview
Link to pdf file of genomes list
- Initial sign-up for teams of four students for computer exercises and papers
Literature:
Chapters 1 (16 pages) and 2 (18 pages) in the textbook Signature in the Cell book review
Thursday, 1 September, 2011
- 13.00-13.30
- Discussion of projects and groups of genomes for computer exercises and reports
Link to pdf file of genomes list
Link to pdf file of Tammi's talk
- 13.30-13.45
- Break
- 13.45-14.30
- Chapter 3 from textbook - "Comparative Microbial Genomics: A Brief Overview"
Link to pdf file of lecture notes
- 14.30-14.45
- Break
- 14.45-15.30
- Chapter 4 from textbook - "Genomic Databases"
Link to pdf file of lecture notes
- 15.30-15.45
- Break
- 15.45-16.30
- Discussion about what is expected
Literature:
Chapters 3 (14 pages) and 4 (12 pages) in the textbook
Ten Simple Rules for Getting Published
Wednesday, 7 September, 2011 Introduction to Unix and CMG biotools, downloading genomes
- 8.30-9.15
- Lecture by Matloob Qureshi - Chapter 5 from textbook - "The Challenges of Programming"
- 9.15-9.30
- Break
- 9.30-10.00
- "Unix How-to lecture" by Matloob Qureshi
- 10.00-12.00
- Introduction to groups for the course:
Literature:
Chapter 5 of the textbook (21 pages).
Unix-How-To Guide
Bacterial Genome Groups for Journal Club, Posters, and Papers

Thursday, 8 September, 2011
-
- 13.00-13.45
- Chapter 6 from textbook - "Comparing Genomes - Bacterial Genomics"
Link to pdf file of lecture notes (final version)
- 13.45-14.00
- Break
- 14.00-14.30
- Example Journal Club - "Defining the Pseudomonas Genus"
Link to pdf file of presentation slides
- 14.30-16.30
- Computer exercises - Week 1.
Link to pdf file of lecture notes
Literature:
Chapter 6 (9 pages) in the textbook Link to Pseudomonas Journal Club article
Link to PubMed

Wednesday, 14 September, 2011 Gene Finding & Basic Genome Statistics
- 8.30-9.15
- Chapters 7, 8 from textbook - "Genomic Properties"
Link to pdf file of lecture notes (final version)
- 9.15-9.30
- Break
- 9.30-10.00
- Journal Club # 1 - Acinetobacter - Linda, Monica, Malene, Isa
Link to pdf file of journal club
- 10.00-10.15
- Break
- 10.15-10.45
- Journal Club # 2 - Lactobacillus - Linda, Dilek, Catharina
Link to pdf file of journal club
- 10.45-12.00
- Computer exercises - Week 2, day 1.
other files - updated 14 September, 2011... GeneWiz executable
GenomeAtlas configuration file generator script
NEW genomeatlas shell script (to replace the old one!)
Literature:
Chapter 7 (21 pages) and Chapter 8 (11 pages) in the textbook, Link to Acinetobacter (Journal Club # 1) article, Link to Lactobacillus (Journal Club # 2) article.
Thursday, 15 September, 2011
- 13.00-13.45
- Chapter 9 from textbook - "Transcriptomics"
Link to pdf file of lecture notes
- 13.45-14.00
- Break
- 14.00-14.30
- Journal Club # 3 - Salmonella - Martin, Tanni, Sandra, Sebastian, Julie
Link to pdf file of journal club
- 14.30-14.45
- Break
- 14.45-15.15
- Journal Club # 4 - Bifidobacterium - Stine, Dan, Lene, Sufia
Link to pdf file of journal club
- 15.15-17.00
- Computer exercises - Week 2, day 2.
Literature:
Chapter 9 (12 pages) in the textbook, Link to Salmonella (Journal Club # 3) article , Link to Bifidobacterium (Journal Club # 4) article.

Wednesday, 21 September, 2011 - Ribosomal sequence analysis, basic phylogenetics
- 8.30-9:30
- Computer exercises - Week 3, day 1.
PDF of presentation (overview of computer exercises for Week 3)
- 9.30-10.15
- Chapter 13 from textbook - "Metagenomics" - special guest lecture by Professor Francisco Rodriguez-Valera, Universidad Miguel Hernandez, San Juan de Alicante, Spain
Link to pdf file of lecture notes
- 10.15-10.30
- Break
- 10.30-11.00
- Journal Club # 5 - Brucella - Ola, Una, Michael, Maja
Link to pdf file of journal club
- 11.00-11.15
- Break
- 11.15-11.45
- Journal Club # 6 - Escherichia - Yongguang, Katarzyna, Jing, Boryana
Link to pdf file of journal club
Literature:
Chapters 13 (14 pages) in the textbook, Link to Brucella (Journal Club # 5) article , Link to Escherichia (Journal Club # 6) article .
Thursday, 22 September, 2011
- 13.00-13.45
- Chapter 10 from textbook - "Expression of Genes and Proteins"
Link to pdf file of lecture notes
- 13.45-14.00
- Break
- 14.00-14.30
- Chapter 11 from textbook - "Of Proteins, Genomes, and Proteomes"
Link to pdf file of lecture notes
- 14.30-14.45
- Break
- 14.45-15.15
- Journal Club # 7 - Vibrio - Iliana, Susan, Kasper, Dominika
Link to pdf file of journal club
- 15.15-15.30
- Break
- 15.30-16.00
- Journal Club # 8 - Staphylococcus - Henrik, Marc, Athansios, Rasmus, Marwa
Link to pdf file of journal club
- 16.00-17.00
- Computer exercises - Week 3, day 2.
Literature:
Chapters 10 (19 pages) and 11 (15 pages) in the textbook, Link to Vibrio (Journal Club # 7) article , Link to Staphylococcus (Journal Club # 8) article .

Wednesday, 28 September, 2011 - Proteome comparisons
- 8.00-8.45
- Chapter 12 from textbook - "Microbial Communities"
Link to pdf file of lecture notes
- 8.45-9.00
- Break
- 9.00-9.45
- Chapter 14 from textbook
Link to pdf file of lecture notes
- 9.45-10.00
- Break
- 10.00-10.30
- Journal Club # 9 - Bacillus - Tine, Martin, Niels, Sabine
Link to pdf file of journal club
- 10.30-12.00
- Computer exercises.
Literature:
Chapters 12 and 14 of the textbook, Link to Bacillus (Journal Club # 9) article
Thursday, 29 September, 2011
-
- 13.00-17.00
- Computer exercises.
Wednesday, 5 October, 2011 Work on Posters
- 10.00-10:30
- Lecture on posters - some tips of what to include, and what makes a good poster
Link to page for zoomable atlases Link to PDF of zoomable atlas paper describing method
Thursday, 6 October, 2011 Work on Posters
Wednesday, 12 October, 2011 Work on Posters
Thursday, 13 October, 2011 Work on Posters
Wednesday and Thursday, 19-20 October, 2011
Autumn Break
Wednesday, 26 October, 2011 - Submit poster
Thursday, 27 October, 2011 - POSTER party! Work on Papers
Wednesday, 2 November, 2011 Work on Papers
Thursday, 3 November, 2011 Work on Papers
Wednesday, 9 November, 2011 Work on Papers
Thursday, 10 November, 2011 Work on Papers
-
- 13.00-14.00
- Lecture on What is Expected for the final paper
link to pdf of lecture notes.
Wednesday, 16 November, 2011 Work on Papers
Thursday, 17 November, 2011 - Hand in papers for Critique in class

Wednesday, 23 November, 2011 Revise papers (if necessary)
Thursday, 24 November, 2011 WRevise papers (if necessary)
Thursday, 1 December, 2011 - FINAL PAPERS due
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