Biology 210
GENETICS
13 April, 1998

1. General Properties of Mutations

2. The Molecular Basis of Gene Mutations

3. Spontaneous Mutations
• Errors in DNA Replication
• Spontaneous Lesions
• Spontaneous Mutations and Human diseases

4. Induced Mutations

1. General Properties of Mutations

2. The Molecular Basis of Gene Mutations













3. Spontaneous Mutations


• Errors in DNA Replication:
transitions
transversions
frameshifts
"hot spots"
deletions
duplications









• Spontaneous Lesions:
depurination
deamination
oxidative damage to DNA bases

• Spontaneous Mutations and Human diseases

4. Induced Mutations
Base-Analog Mutagens
Chemical Agents that Modify DNA
Misalignment Mutagenesis
Ultraviolet Irradiation
Ionizing Radiation

Back to the Genetics Syllabus

Last modified on: 19 February, 2000 by Dave Ussery