30431 Introduktion til Bioinormatik
David Ussery
Tirsdag, 8 September, 1998
 
 Biological Sequences and Information
 

Required reading: Chapter 1 & Appendix B, from Baldi and Brunak

O Part 1: Nucleic acid and protein sequence as information

Outline:

  • Schrödinger and Morse Code
  • Biological Sequence as Information
  • A few words about the speed of DNA sequencing
  • On the sizes of genomes and proteomes
  • How to do a "blast search" of a DNA or protein sequence
    • Self-test QUIZ
     
     
     background on "The Central Dogma of molecular biology"


    O Part 2: Complexity and Genome Organisation: Implications for Sequence Analysis

    Outline:
  • A closer look at the sizes of genomes
  • The "C-value" paradox
  • Characterisation of Repetitive DNA
  • Repetitive DNA can cause problems in sequence analysis
  • Logo plots of aligned sequences
    • Self-test QUIZ
     

     

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